Iopanoic acid
- CAS No.
- 96-83-3
- Chemical Name:
- Iopanoic acid
- Synonyms
- Bilipac;colepax;win2011;Bilumbal;Iopanoic;cholevid;cistobil;COPANOIC;NSC 41706;Bilijodan
- CBNumber:
- CB0753539
- Molecular Formula:
- C11H12I3NO2
- Molecular Weight:
- 570.93
- MDL Number:
- MFCD00038687
- MOL File:
- 96-83-3.mol
| Melting point | 153 °C |
|---|---|
| Boiling point | 529.1±50.0 °C(Predicted) |
| Density | 2.2567 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO, Methanol |
| pka | 4.8(at 25℃) |
| color | Light Brown |
| Water Solubility | 348.3mg/L(37 ºC) |
| Merck | 14,5058 |
| BCS Class | 2 |
| CAS DataBase Reference | 96-83-3(CAS DataBase Reference) |
| FDA UNII | FE9794P71J |
| ATC code | V08AC06 |
| EPA Substance Registry System | Benzenepropanoic acid, 3-amino-.alpha.-ethyl-2,4,6-triiodo- (96-83-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NW5075000 | |||||||||
| HS Code | 2922.49.3700 | |||||||||
| NFPA 704 |
|
Iopanoic acid price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I0330000 | Iopanoic acid European Pharmacopoeia (EP) Reference Standard | 96-83-3 | i0330000 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | 14131 | Iopanoic acid analytical standard | 96-83-3 | 100mg | $78.4 | 2021-12-16 | Buy |
| TCI Chemical | I0300 | Iopanoic Acid >98.0%(T) | 96-83-3 | 5g | $209 | 2024-03-01 | Buy |
| TCI Chemical | I0300 | Iopanoic Acid >98.0%(T) | 96-83-3 | 25g | $840 | 2024-03-01 | Buy |
| TRC | I717400 | IodopanoicAcid | 96-83-3 | 10g | $990 | 2021-12-16 | Buy |
Iopanoic acid Chemical Properties,Uses,Production
Chemical Properties
Light Brown Solid
Originator
Telepaque,Winthrop,US,1952
Uses
antiulcer
Uses
Iodopanoic Acid is an iodine-containing radiocontrast medium used in cholecystography. Iodopanoic Acid is a potent inhibitor of thyroid hormone release from thyroid gland.
Definition
ChEBI: Iopanoic acid is a monocarboxylic acid.
Manufacturing Process
(A) Preparation of α-Ethyl-m-Nitrocinnamic Acid: This acid is prepared from
100 g of m-nitrobenzaldehyde, 210 g of butyric anhydride and 73 g of sodium
butyrate. The crude α-ethyl-m-nitrocinnamicacid is crystallized from ethanol
giving about 105 g, MP 140° to 142°C. From the filtrates there may be
isolated a small amount of a stereoisomer, which when pure melts at 105° to
106°C.
(B) Preparation of m-Amino-α-Ethylhydrocinnamic Acid: A mixture of 50 g of
α-ethyl-m-nitrocinnamic acid, 9.1 g of sodium hydroxide, 600 cc of water and
5 teaspoons of Raney nickel catalyst is shaken at 32°C in an atmosphere ofhydrogen at an initial pressure of 450 psi until the calculated amount of
hydrogen is absorbed. The filtered solution is acidified with hydrochloric acid,
made basic with ammonium hydroxide and again acidified with acetic acid.
Upon concentration of this solution, an oil separates which crystallizes upon
standing, giving about 20 g, MP 60° to 68°C. Complete evaporation of the
filtrate and extraction of the residue of inorganic salts with ether gives about
20 g of additional material, MP 54° to 59°C. Recrystallization of the combined
product from benzene petroleum ether gives about 35 g of m-amino-α-
ethylhydrocinnamic acid, MP 67° to 70°C.
(C) Preparation of β-(3-Amino-2,4,6-Triiodophenyll-α-Ethylpropionic Acid: A
solution of 5.0 g of m-amino-α-ethylhydrocinnamic acid in 100 cc of water
containing 5 cc of concentrated hydrochloric acid is added over a period of ?
hour to a stirred solution of 3.2 cc of iodine monochloride in 25 cc of water
and 25 cc of concentrated hydrochloric acid heated to 60°C. After addition is
complete, the heating is continued for one hour longer at 60° to 70°C. A black
oil separates which gradually solidifies.
The mixture is then cooled and sodium bisulfite added to decolorize.
Recrystallization of the product from methanol gives about 8 g, MP 147° to
150°C. The β-(3-amino-2,4,6-triiodophenyl)-α-ethylpropionic acid may be
purified further by precipitation of the morpholine salt from ether solution and
regeneration of the free amino acid by treatment of a methanol solution of the
morpholine salt with sulfur dioxide. The pure amino acid has the MP 155° to
156.5°C.
Therapeutic Function
Diagnostic aid (radiopaque medium)
Iopanoic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 879 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from Iopanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-20 | Iopanoic acid
96-83-3
|
US $350.00 / KG | 1KG | 99% | 9000kg/per week | Hebei Lingding Biotechnology Co., Ltd. | |
 |
2021-08-14 | Iopanoic acid USP/EP/BP
96-83-3
|
US $1.10 / g | 1g | 0.999 | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-08-12 | Iopanoic acid
96-83-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Iopanoic acid
96-83-3
- US $350.00 / KG
- 99%
- Hebei Lingding Biotechnology Co., Ltd.
-
- Iopanoic acid USP/EP/BP
96-83-3
- US $1.10 / g
- 0.999
- Dideu Industries Group Limited
-
- Iopanoic acid
96-83-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd