4-HYDROXYTAMOXIFEN
- CAS No.
- 68047-06-3
- Chemical Name:
- 4-HYDROXYTAMOXIFEN
- Synonyms
- hydroxytamoxifen;4-OHT;C05011;(Z)-4-OHT;ici79,280;(E)-4’4-Benzyloxy β4-HYDROXYTAMOXIFEN;TAMOXIFEN, 4-HYDROXY-;cis-4-Hydroxytamoxifen
- CBNumber:
- CB0754622
- Molecular Formula:
- C26H29NO2
- Molecular Weight:
- 387.51
- MDL Number:
- MFCD00468090
- MOL File:
- 68047-06-3.mol
- MSDS File:
- SDS
| Melting point | 105-107°C |
|---|---|
| Boiling point | 513.45°C (rough estimate) |
| Density | 1.1005 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | 95% ethanol: 20 mg/mL |
| pka | 10.35±0.15(Predicted) |
| form | powder |
| color | white |
| Stability | Stable. Store cool. Incompatible with strong oxidizing agents. |
| InChIKey | TXUZVZSFRXZGTL-OCEACIFDSA-N |
| CAS DataBase Reference | 68047-06-3 |
| NCI Dictionary of Cancer Terms | 4-hydroxytamoxifen |
| FDA UNII | 95K54647BZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H350-H360FD-H410 | |||||||||
| Precautionary statements | P201-P202-P264-P273-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-63 | |||||||||
| Safety Statements | 22-23-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SL1210000 | |||||||||
| NFPA 704 |
|
4-HYDROXYTAMOXIFEN price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H7904 | (Z)-4-Hydroxytamoxifen ≥98% Z isomer | 68047-06-3 | 5mg | $183 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.08225 | InSolution Tamoxifen, 4-Hydroxy-, ( Z)- - CAS 68047-06-3 - Calbiochem | 68047-06-3 | 2mg | $96.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 579002 | Tamoxifen, 4-Hydroxy-, (Z)- | 68047-06-3 | 5mg | $223 | 2023-01-07 | Buy |
| Cayman Chemical | 14854 | (Z)-4-hydroxy Tamoxifen ≥98% | 68047-06-3 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 14854 | (Z)-4-hydroxy Tamoxifen ≥98% | 68047-06-3 | 5mg | $134 | 2024-03-01 | Buy |
4-HYDROXYTAMOXIFEN Chemical Properties,Uses,Production
Chemical Properties
Powder
Uses
tamoxifen metabolite, anti-estrogen, see Tamoxifen 1,01038
Uses
A metabolite of Tamoxifen (T006000). A hydroxylated analogue of Tamoxifen with anti-estrogenic properties.
Uses
(Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen (T006000). (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties.
Uses
A hydroxylated analogue of tamoxifen with anti-estrogenic properties. A metabolite of Tamoxifen.
Definition
ChEBI: Afimoxifene is a tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. It has a role as an antineoplastic agent, an estrogen receptor antagonist and a metabolite. It is a tertiary amino compound and a member of phenols. It is functionally related to a tamoxifen.
General Description
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).
Biological Activity
estrogen receptors (er) are members of the superfamily of ligand-modulated nuclear receptors that mediate the actions of steroid hormones, vitamin d, retinoids, and thyroid hormones. er is activated in vivo when bound by naturally occurring estrogens such as 17α-estradiol. in addition to regulating these physiological processes, estrogen also plays a central role in stimulating breast cancer growth. (z)-tamoxifen is a first generation selective er modulators that is currently approved by the fda and is widely used to treat estrogen-dependent breast cancers. its active metabolite, (z)-4-hydroxytamoxifen, is a potent estrogen receptor modulator.
Biochem/physiol Actions
Cell permeable: yes
in vitro
(z)-4-hydroxytamoxifen binds to er with 8-fold higher affinity than tamoxifen. it was found that only the z isomer has the required antiestrogenic activity; the (e)-4-hydroxytamoxifen has only about 5% of its affinity for the er [1].
in vivo
the antioestrogenic activities of (z)-4-hydroxytamoxifen and tamoxifen were determined after oral administration. (z)-4-hydroxytamoxifen was administered to groups of immature rats which also received s.c. injections of 0-2 μg oestradiol. both compounds produced a dose-related decrease in uterine wet weight when compared with the oestradiol-treated controls. at a dose of 1 μg/day, the antiuterotrophic effects of (z)-4-hydroxytamoxifen and tamoxifen were not significantly different but at 5μg/day, (z)-4-hydroxytamoxifen was more active (p < 0.01). (z)-4-hydroxytamoxifen therefore appears to retain its potent antioestrogenic activity after oral administration [2].
storage
-20°C
References
[1] donna d. yu and barry m. forman. simple and efficient production of (z)-4-hydroxytamoxifen, a potent estrogen receptor modulator. j. org. chem. 2003, 68, 9489-9491
[2] jordan vc, collins mm, rowsby l, prestwich g. a monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. j endocrinol. 1977 nov;75(2):305-16.
4-HYDROXYTAMOXIFEN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3783 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12431 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from 4-HYDROXYTAMOXIFEN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 4-HYDROXYTAMOXIFEN
68047-06-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-06-25 | 4-HYDROXYTAMOXIFEN USP/EP/BP
68047-06-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-10 | (Z)-4-Hydroxy TaMoxifen
68047-06-3
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-HYDROXYTAMOXIFEN
68047-06-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-HYDROXYTAMOXIFEN USP/EP/BP
68047-06-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- (Z)-4-Hydroxy TaMoxifen
68047-06-3
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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