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Diacerein

Immunosuppressive drugs Uses
Diacerein
Diacerein structure
CAS No.
13739-02-1
Chemical Name:
Diacerein
Synonyms
DAR;SF 277;artrodar;Fisiodar;DIACEREIN;DIACERHEIN;Diacereine;Diacerein>Diacerein CRS;DIACETYL RHEIN
CBNumber:
CB0755179
Molecular Formula:
C19H12O8
Formula Weight:
368.29
MOL File:
13739-02-1.mol

Diacerein Properties

Melting point:
217-2180C
Boiling point:
631.5±55.0 °C(Predicted)
Density 
1.491±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.01±0.20(Predicted)
form 
neat
Merck 
14,2960
InChIKey
TYNLGDBUJLVSMA-UHFFFAOYSA-N
CAS DataBase Reference
13739-02-1(CAS DataBase Reference)
FDA UNII
4HU6J11EL5
NCI Dictionary of Cancer Terms
DAR
ATC code
M01AX21
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  CB8781000
HS Code  29146990

Diacerein price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9302 Diacerein ≥95% (HPLC) 13739-02-1 50mg $173 2021-03-22 Buy
Sigma-Aldrich Y0001595 Diacerein European Pharmacopoeia (EP) Reference Standard 13739-02-1 y0001595 $190 2020-08-18 Buy
Sigma-Aldrich Y0001595 Diacerein European Pharmacopoeia (EP) Reference Standard 13739-02-1 $190 2021-03-22 Buy
TCI Chemical D4061 Diacerein >98.0%(HPLC) 13739-02-1 1g $120 2021-03-22 Buy
TCI Chemical D4061 Diacerein >98.0%(HPLC) 13739-02-1 5g $311 2021-03-22 Buy

Diacerein Chemical Properties,Uses,Production

Immunosuppressive drugs

Diacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.

Uses

It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.

Description

Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.

Chemical Properties

Yellow Crystalline Solid

Originator

Proter (Italy)

Uses

A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic

Uses

antiinflammatory

Uses

A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.

Uses

Treatment of Osteoarthritis (Prevent cartilage destruction)

Uses

Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.

brand name

ARTRODAR

Diacerein Preparation Products And Raw materials

Raw materials

Preparation Products


Diacerein Suppliers

Global( 362)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5912 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 376 58

View Lastest Price from Diacerein manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Diacerein
13739-02-1
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-12-01 Diacerein for Arthritis Treatment
13739-02-1
US $10.00 / Kg 1KG 99 500kg/month Handan Tongyi New Material Technology Co., Ltd
2021-11-30 Diacerein
13739-02-1
US $500.00 / KG 1KG 99% 100kg Baoji Guokang Bio-Technology Co., Ltd.

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