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Diacerein

Immunosuppressive drugs Uses
Diacerein
Diacerein structure
CAS No.
13739-02-1
Chemical Name:
Diacerein
Synonyms
DAR;SF 277;artrodar;Fisiodar;DIACEREIN;DIACERHEIN;Diacereine;DIACETYL RHEIN;rhein,diacetate;4,5-diacetylrhein
CBNumber:
CB0755179
Molecular Formula:
C19H12O8
Formula Weight:
368.29
MOL File:
13739-02-1.mol

Diacerein Properties

Melting point:
217-2180C
Boiling point:
631.5±55.0 °C(Predicted)
Density 
1.491±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
pka
3.01±0.20(Predicted)
form 
neat
Merck 
14,2960
InChIKey
TYNLGDBUJLVSMA-UHFFFAOYSA-N
CAS DataBase Reference
13739-02-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  CB8781000
HS Code  29146990

Diacerein price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9302 Diacerein ≥95% (HPLC) 13739-02-1 50mg $158 2019-12-02 Buy
Sigma-Aldrich Y0001595 Diacerein European Pharmacopoeia (EP) Reference Standard 13739-02-1 y0001595 $183 2019-12-02 Buy
TCI Chemical D4061 Diacerein >98.0%(HPLC) 13739-02-1 1g $117 2019-12-02 Buy
TCI Chemical D4061 Diacerein >98.0%(HPLC) 13739-02-1 5g $396 2019-12-02 Buy
Alfa Aesar J63775 Diacerein 13739-02-1 5g $449 2019-12-02 Buy

Diacerein Chemical Properties,Uses,Production

Immunosuppressive drugs

Diacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.

Uses

It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.

Description

Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.

Chemical Properties

Yellow Crystalline Solid

Originator

Proter (Italy)

Uses

A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic

Uses

antiinflammatory

Uses

A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.

Uses

Treatment of Osteoarthritis (Prevent cartilage destruction)

Uses

Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.

brand name

ARTRODAR

Diacerein Preparation Products And Raw materials

Raw materials

Preparation Products


Diacerein Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29996 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23981 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8835 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1276 58

View Lastest Price from Diacerein manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-11-15 Diacerein
13739-02-1
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-07-16 Diacerein 13739-02-1
13739-02-1
US $26.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2018-12-16 Diacerein
13739-02-1
US $8.00 / kg 1kg 98% 10MT career henan chemical co

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