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2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER

CAS No.
10076-48-9
Chemical Name:
2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER
Synonyms
METHYL 2,2-DIMETHOXYPROPIONATE;METHYL 2,2-DIMETHOXYPROPANOATE;METHYL PYRUVATE DIMETHYL ACETAL;Methyl2,2-Dimethoxypropionate>Dimethoxypropionicacidmethylester;2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER;Propanoic acid, 2,2-dimethoxy-, methyl ester;2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER, 96+%
CBNumber:
CB0755447
Molecular Formula:
C6H12O4
Molecular Weight:
148.16
MDL Number:
MFCD00048066
MOL File:
10076-48-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:40
Product description Number Pack Size Price
Methyl 2,2-Dimethoxypropionate >96.0%(GC) D2382 25g $241
Methyl2,2-Dimethoxypropanoate M303733 250mg $45
Methyl2,2-dimethoxypropanoate 0266AA 25g $370
2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER 95.00% CHM0007543 5MG $500.6
Methyl2,2-dimethoxypropanoate 98% A167678 5g $60

2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER Properties

Boiling point 70 °C / 13mmHg
Density 1.07
refractive index 1.4100-1.4120
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form clear liquid
color Colorless to Almost colorless
CAS DataBase Reference 10076-48-9

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H227
Precautionary statements  P210-P280-P370+P378-P403+P235-P501
HS Code  2918.19.9000

2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D2382 Methyl 2,2-Dimethoxypropionate >96.0%(GC) 10076-48-9 25g $241 2025-07-31 Buy
TRC M303733 Methyl2,2-Dimethoxypropanoate 10076-48-9 250mg $45 2021-12-16 Buy
AK Scientific 0266AA Methyl2,2-dimethoxypropanoate 10076-48-9 25g $370 2021-12-16 Buy
American Custom Chemicals Corporation CHM0007543 2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER 95.00% 10076-48-9 5MG $500.6 2021-12-16 Buy
Ambeed A167678 Methyl2,2-dimethoxypropanoate 98% 10076-48-9 5g $60 2021-12-16 Buy
Product number Packaging Price Buy
D2382 25g $241 Buy
M303733 250mg $45 Buy
0266AA 25g $370 Buy
CHM0007543 5MG $500.6 Buy
A167678 5g $60 Buy

2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER Chemical Properties,Uses,Production

Synthesis

Methyl pyruvate

600-22-6

Trimethoxymethane

149-73-5

2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER

10076-48-9

General procedure for the synthesis of methyl 2,2-dimethoxypropionate from methyl pyruvate and trimethyl orthoformate: 100 g (979 mmol) of methyl pyruvate was mixed with 135 g (1273 mmol) of trimethyl orthoformate in 240 ml of methanol. After adding 0.96 g (9.79 mmol) of concentrated sulfuric acid, the mixture was heated to reflux for 4 hours. Subsequently, the solvent was distilled out over 2 h. The crude product was cooled to 10 °C and added to a solution of 2.4 g of potassium hydroxide in 1200 ml of water at 10 °C. After repeated extraction with ether, the organic phases were combined and dried over anhydrous sodium sulfate, filtered and concentrated. The residue was distilled under reduced pressure and the fractions with boiling points of 50-55°C (10 mbar) were collected. Finally 118 g (77% yield) of the target product was obtained.1H NMR (CDCl3) data were as follows: δ = 1.53 (s, 3H, C-CH3), 3.29 (s, 6H, CH3-OCO-CH3), 3.82 (s, 3H, COOCH3).

References

[1] Journal of the American Chemical Society, 1983, vol. 105, # 7, p. 2021 - 2029
[2] Patent: US2015/245616, 2015, A1. Location in patent: Paragraph 0189; 0190

67-56-1
600-22-6
149-73-5
10076-48-9
Synthesis of 2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER from Methanol and Methyl pyruvate and Trimethoxymethane

2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER Preparation Products And Raw materials

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2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER METHYL 2,2-DIMETHOXYPROPIONATE METHYL PYRUVATE DIMETHYL ACETAL Dimethoxypropionicacidmethylester METHYL 2,2-DIMETHOXYPROPANOATE 2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER, 96+% Methyl2,2-Dimethoxypropionate> Propanoic acid, 2,2-dimethoxy-, methyl ester 10076-48-9