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HERBIMYCIN A

HERBIMYCIN A
HERBIMYCIN A structure
CAS No.
70563-58-5
Chemical Name:
HERBIMYCIN A
Synonyms
C11225;herbimycin;HERBIMYCIN A;antibiotictan420f;(15r)-geldanamyci;HerbiMycin, TAN 420F;HERBIMYCIN A USP/EP/BP;Herbimycin A, Streptomyces sp.;HERBIMYCIN A, STREPTOMYCES SPECIES;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS
CBNumber:
CB0756080
Molecular Formula:
C30H42N2O9
Formula Weight:
574.66
MOL File:
70563-58-5.mol

HERBIMYCIN A Properties

Melting point:
229-231 °C
Boiling point:
752℃
Density 
1.19±0.1 g/cm3(Predicted)
Flash point:
>110°(230°F)
storage temp. 
−20°C
solubility 
DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
form 
powder
pka
8.56±0.70(Predicted)
color 
yellow
Sensitive 
Light Sensitive & Hygroscopic
BRN 
4834067
CAS DataBase Reference
70563-58-5
FDA UNII
815WDV2HST
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  LX8930000
10-21
HS Code  29419000

HERBIMYCIN A price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 375670 Herbimycin A, A potent and cell-permeable protein tyrosine kinase inhibitor. 70563-58-5 100ug $227 2021-12-16 Buy
Sigma-Aldrich H6649 Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder 70563-58-5 0.1 mg $265 2021-12-16 Buy
Sigma-Aldrich H6649 Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder 70563-58-5 .1mg $1120 2021-12-16 Buy
Alfa Aesar J66427 Herbimycin A, 95% 70563-58-5 1mg $829 2021-12-16 Buy
Cayman Chemical 15504 Herbimycin A ≥99% 70563-58-5 2.5mg $1014 2021-12-16 Buy

HERBIMYCIN A Chemical Properties,Uses,Production

Uses

Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.

Uses

Herbimycin A is an inhibitor of c-Abl, HSP 90, c-Src, c-Yes, Fes, and Ros. It is a COVID19-related research product.

Uses

Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.

Definition

ChEBI: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.

General Description

A cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 μM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 μg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.

Biological Activity

Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.

Biochem/physiol Actions

Cell permeable: yes

HERBIMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products


HERBIMYCIN A Suppliers

Global( 77)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
15336106720
029-88380327 1017@dideu.com CHINA 3979 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
BOC Sciences
16314854226
inquiry@bocsci.com United States 19674 58
Henan Alfa Chemical Co., Ltd
+8619139973225
adam@alfa-chemical.com;sales4@alfachem.cn;alfa8@alfachem.cn China 12083 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15877 69
BOC Sciences 16314854226
info@bocsci.com United States 21113 65

View Lastest Price from HERBIMYCIN A manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-25 HERBIMYCIN A USP/EP/BP
70563-58-5
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-05-10 Herbimycin A from Streptomyces hygroscopicus
70563-58-5
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2019-12-26 HERBIMYCIN A
70563-58-5
US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co

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