ChemicalBook >> CAS DataBase List >>4-Hydroxycoumarin


Chemical Name:
4-HYDROXY-2H-CHROMEN-2-ONE;HydroxyCoumarin;4-Coumaryl alcohol;4-hydroxy-2h-1-benzopyran-2-on;COUMARINOL;4-HYDROXY-2H-1-BENZOPYRAN-2-ONE;4-Coumarinol;COUMARIN KIT;4-HydroxycouMa;4-HYDROXYCUMARIN
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:
2022-08-15 17:39:42

4-Hydroxycoumarin Properties

Melting point 211-213 °C (lit.)
Boiling point 228.82°C (rough estimate)
Density 1.1734 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly)
form Liquid
pka 4.50±1.00(Predicted)
color Clear colorless to slightly yellow
BRN 129768
CAS DataBase Reference 1076-38-6(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 4-Hydroxycoumarin(1076-38-6)
EPA Substance Registry System 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)


Risk and Safety Statements

Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3100000
Hazard Note  Irritant
HS Code  29322980

4-Hydroxycoumarin price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H23805 4-Hydroxycoumarin 98% 1076-38-6 100g $55.3 2022-05-15 Buy
Sigma-Aldrich H23805 4-Hydroxycoumarin 98% 1076-38-6 500g $176 2022-05-15 Buy
Sigma-Aldrich 40863 4-Hydroxycoumarin analytical standard 1076-38-6 100MG $60.8 2022-05-15 Buy
TCI Chemical H0235 4-Hydroxycoumarin >98.0%(GC)(T) 1076-38-6 25g $35 2022-04-27 Buy
TCI Chemical H0235 4-Hydroxycoumarin >98.0%(GC)(T) 1076-38-6 250g $255 2022-04-27 Buy
Product number Packaging Price Buy
H23805 100g $55.3 Buy
H23805 500g $176 Buy
40863 100MG $60.8 Buy
H0235 25g $35 Buy
H0235 250g $255 Buy

4-Hydroxycoumarin Chemical Properties,Uses,Production

Chemical Properties

Yellow powder or chunks or Slightly yellow needle-like crystals.  freely soluble in ethanol, ether and hot water. brown in color with ferric chloride.


4-Hydroxycoumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarins are a very important class of biologically active drugs which are widely used as anticoagulants-Warfarin and Acenocoumarol.


4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.


4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
RuCl3.nH2O catalyzed synthesis of biscoumarins
Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst.


ChEBI: 4-hydroxycoumarin is a hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group. It is a conjugate acid of a 4-hydroxycoumarin(1-).

Synthesis Reference(s)

The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630

Purification Methods

Crystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]

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View Lastest Price from 4-Hydroxycoumarin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-14 4-Hydroxycoumarin
US $0.00 / KG 1KG 99% 100mt/year Jinan Finer Chemical Co., Ltd
2022-04-29 4-Hydroxycoumarin
US $10.00 / kg 1kg 99% 10000Ton Hebei Crovell Biotech Co Ltd
2022-03-29 4-Hydroxycoumarin
US $1.00 / kg 1kg 99% 1ton Henan Guange Biotechnology Co. LTD
4-HYDROXY-CHROMEN-2-ONE 4-HYDROXYCOUMARIN 4-HYDROXYCUMARIN 4-HYDROXY-1-BENZOPYRAN-2-ONE AKOS BBS-00000696 4-Coumarinol 4-HYDROXYCOUMARIN FOR SYNTHESIS 4-hydroxy-couMarin, 4-hydroxy-2H-benzopyran-2-one, 4-hydroxy-2-chroMenone, 4-hydroxycouMarin, 4-hydroxy-2H-benzopyran-2-one, 4-hydroxy-2H-benzo-1-pyran-2-one, 4-hydroxy-2H-benzo[b]pyran-2-one Warfarin EP IMpurity-B 4-HydroxycouMa 4-Hydroxycoumarin Vetec(TM) reagent grade, 98% 4-HYDROXYCOUMARIN, FOR FLUORESCENCE 4-Hydroxycoumarin99% 4-(3-hydroxyprop-1-enyl)phenol 4-HYDROXYCOUMARIN (98.0%) CHROMANONE, 4-(RG) HYDROXYCOUMARIN, 4-(RG) 1-BENZOPYRAN-2-ONE,4-HYDROXY- 4-hydroxy-coumari 4-Hydroxycoumarine Benzotertonicacid Benzotetronic acid Coumarin, 4-hydroxy- COUMARIN KIT 4-Hydroxycoumarin , (4-hydroxy-1-benzopyran-2-one) β-Hydroxy-o-couMaric lactone 4-Hydroxycoumarin, 98+% 4-Hydroxy-2H-1-benzopyrene-2-one 2-Hydroxychromen-4-one HYDROXYCOUMARIN, 4- 2H-1-BENZOPYRAN-2-ONE, 4-HYDROXY- 4-coumarinyl alcohol Warfarin sodium EP Impurity B Warfarin Impurity 2(Warfarin Impurity B) 7-hydroxy-1-benzopyran-2-one 4-HydroxycoumarinN 4-Hydroxycoumarin 1076-38-6 4-Hydroxy-1-benzopyran-2-one 1076-38-6 Warfarin Impurity B 4-Hydroxy-2H-1-benzopyran-2-one (4- 4-Hydroxycoumarin> Warfarin EP Impurity B (4-Hydroxy Coumarin) Warfarin Impurity 2(Warfarin EP Impurity B) 4-Hydroxycoumarin ISO 9001:2015 REACH 4-Hydroxycoumarin,HPLC≥98% 4-HYDROXYCOMARINS 2-hydroxy-4H-chromen-4-one Warfarin Impurity BQ: What is Warfarin Impurity B Q: What is the CAS Number of Warfarin Impurity B Q: What is the storage condition of Warfarin Impurity B Q: What are the applications of Warfarin Impurity B 4-HYDROXY-2H-1-BENZOPYRAN-2-ONE 4-HYDROXY-2H-CHROMEN-2-ONE 4-Coumaryl alcohol HydroxyCoumarin 4-hydroxy-2h-1-benzopyran-2-on COUMARINOL 1076-38-6 Fluorescent Probes, Labels, Particles and Stains Heterocyclic Building Blocks Detection