ChemicalBook >> CAS DataBase List >>NIKKOMYCIN Z
NIKKOMYCIN Z
- CAS No.
- 59456-70-1
- Chemical Name:
- NIKKOMYCIN Z
- Synonyms
- NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
- CBNumber:
- CB0767000
- Molecular Formula:
- C20H25N5O10
- Molecular Weight:
- 495.44
- MDL Number:
- MFCD00869648
- MOL File:
- 59456-70-1.mol
Last updated:2023-05-18 11:31:20
| Density | 1.646±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL |
| pka | 2.70±0.10(Predicted) |
| Water Solubility | Water : ≥ 100 mg/mL (201.84 mM) |
| FDA UNII | 9Z22C3QQCJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | BA2928200 |
| F | 10 |
NIKKOMYCIN Z price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N8028 | Nikkomycin Z from Streptomyces tendae ≥90% (HPLC) | 59456-70-1 | 5mg | $437 | 2024-03-01 | Buy |
| AK Scientific | X6882 | Nikkomycin Z from Streptomyces tendae | 59456-70-1 | 5mg | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0012075 | NIKKOMYCIN 95.00% | 59456-70-1 | 5MG | $502.55 | 2021-12-16 | Buy |
| AHH | MT-56998 | NikkomycinZ 98% | 59456-70-1 | 0.005g | $330 | 2021-12-16 | Buy |
NIKKOMYCIN Z Chemical Properties,Uses,Production
Description
Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
Uses
Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
Definition
ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
Pharmacology
By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
Metabolism
There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
NIKKOMYCIN Z Preparation Products And Raw materials
Raw materials
Preparation Products
NIKKOMYCIN Z Suppliers
Global( 34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shanghai Synchem Pharma Co., ltd | 021-61984905-1 18016477331 | synchempharma@aliyun.com | China | 6454 | 55 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 6912 | 58 |
| Wuhan Rongcan Biotechnology Co., Ltd | 18327024450 | 2130026275@qq.com | China | 4590 | 58 |
Related articles
- Mechanism of action of Nikkomycin Z
- Nikkomycin Z is an experimental compound with antifungal properties. Like all nikkomycins, it consists of a pyrimidine nucleos....
- Mar 31，2022
NIKKOMYCIN
NIKKOMYCIN Z
NIKKOMYCIN Z, STREPTOMYCES TENDAE
(2s-(2r*,3r*,4r*))-l)
5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci
methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny
neopolyoxinc
nikkomycin Z from streptomyces tendae
Nikkomycin Z, Sterptomyces tendae
5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-
huaguamycin
59456-70-1
C20H25N5O10
BioChemical
Antibiotics
Antibiotics A to Z
Antibiotics N-S
AntifungalGlycobiology
InhibitorsAntibiotics
Peptidyl NucleosidesMore...Close...
Inhibitors and Substrates
Peptidyl Nucleosides
Antibiotics
Antibiotics A to
Antibiotics N-SAntibiotics
AntifungalAntibiotics
Chemical Structure Class
Inhibits an EnzymeAntibiotics
Interferes with Cell Wall SynthesisAntibiotics
Mechanism of Action
Spectrum of Activity