ChemicalBook >> CAS DataBase List >>Tryptophol
Tryptophol
- CAS No.
- 526-55-6
- Chemical Name:
- Tryptophol
- Synonyms
- 2-(1H-INDOL-3-YL)ETHAN-1-OL;3-(2-HYDROXYETHYL)INDOLE;INDOLE-3-ETHANOL;IEA;Indoleethanol;3-INDOLEETHANOL;B-3-INDOLYLETHANOL;BETA-3-INDOLYLETHANOL;DK803;NSC 3884
- CBNumber:
- CB0782869
- Molecular Formula:
- C10H11NO
- Molecular Weight:
- 161.2
- MDL Number:
- MFCD00005659
- MOL File:
- 526-55-6.mol
- MSDS File:
- SDS
Last updated:2023-10-21 16:12:53
| Melting point | 56-59 °C(lit.) |
|---|---|
| Boiling point | 174 °C (2.02527 mmHg) |
| Density | 1.0840 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Flash point | 255 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 15.16±0.10(Predicted) |
| form | Crystalline Mass, Crystals, Flakes or Powder |
| color | Off-white to brown |
| Water Solubility | 10 g/L (20 ºC) |
| Merck | 14,9798 |
| BRN | 125553 |
| InChIKey | MBBOMCVGYCRMEA-UHFFFAOYSA-N |
| LogP | 1.280 (est) |
| CAS DataBase Reference | 526-55-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5809LZ7G1U |
| NIST Chemistry Reference | 1H-indole-3-ethanol(526-55-6) |
| EPA Substance Registry System | 1H-Indole-3-ethanol (526-55-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KL3685000 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339990 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 351mg/kg | |||||||||
| NFPA 704 |
|
Tryptophol price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T90301 | 3-(2-Hydroxyethyl)indole 97% | 526-55-6 | 5g | $103 | 2024-03-01 | Buy |
| TCI Chemical | I0030 | 3-Indoleethanol >98.0%(GC) | 526-55-6 | 1g | $35 | 2024-03-01 | Buy |
| TCI Chemical | I0030 | 3-Indoleethanol >98.0%(GC) | 526-55-6 | 5g | $101 | 2024-03-01 | Buy |
| Alfa Aesar | L02555 | Tryptophol, 97% | 526-55-6 | 1g | $26.65 | 2024-03-01 | Buy |
| Alfa Aesar | L02555 | Tryptophol, 97% | 526-55-6 | 5g | $86 | 2024-03-01 | Buy |
Tryptophol Chemical Properties,Uses,Production
Chemical Properties
3-(2-Hydroxyethyl)indole [526-55-6], tryptophol, C10H11NO, Mr 161.20, mp 59 ℃, bp 174 ℃, (2 kPa) forms colorless prisms or flakes that are readily soluble in methanol, ethanol, diethyl ether, chloroform, and acetone, soluble in benzene, and slightly soluble in water. It is produced by reacting methyl-1H-indole-3-acetate with lithium aluminum hydride, or through reduction of methyl-1H-indole-3-glyoxylate with sodium borohydride. The antihypertensive Indoramin is produced from tryptophol.
Uses
Reactant for preparation of:
- Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
- Anti-HIV-1 agents
- Inhibitors of Protein-Protein Interactions
- Partial agonists of the serotonin 5-HT1A receptor
- Growth hormone secretagogues
- Vascular endothelial growth factor (VEGF) inhibitors
- A2B adenosine receptor ligands
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- Inhibitors of interleukine 6
- Dual binding site acetylcholinesterase inhibitors
Uses
Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
Definition
ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070
Purification Methods
Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.]
Tryptophol Preparation Products And Raw materials
Raw materials
carbon monoxide
2-BROMO-3-FLUORO-PHENYLAMINE HYDROCHLORIDE
2-Propen-1-ol,3-(2-aminophenyl)-,(2E)-(9CI)
2-(2,3-dihydro-1H-indol-3-yl)ethan-1-ol
1-TRIETHYLSILYL-4-(TRIETHLYLSILYLOXY)-1-BUTYNE
Allyl alcohol
3-Indoleacetamide
Phenylhydrazine hydrochloride
Methyl indolyl-3-glyoxylate
METHYL 3-INDOLYLACETATE
1of4
Preparation Products
Global( 297)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7838 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from Tryptophol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-21 | Tryptophol
526-55-6
|
US $50.00 / kg | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-03-06 | Tryptophol
526-55-6
|
US $5.70 / Kg/Bag | 10g | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2023-02-11 | Tryptophol
526-55-6
|
US $25.00 / kg | 1kg | 99% | 5000 Ton | Hebei Duling International Trade Co. LTD |
-
- Tryptophol
526-55-6
- US $50.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Tryptophol
526-55-6
- US $5.70 / Kg/Bag
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Tryptophol
526-55-6
- US $25.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
526-55-6(Tryptophol)Related Search:
B-3-INDOLEETHANOL
3-(BETA-HYDROXYETHYL)INDOLE
2-(1H-INDOL-3-YL)-ETHANOL
2-(3-INDOLE)ETHANOL
RARECHEM AH BS 0132
TIMTEC-BB SBB003950
TRYPTOTHOL
TRYPTOPHOL
'TRYPTOPHOL'
1H-Indole-3-ethanol
2-(3-Indolylethanol
3-indolyl-ethano
3-Indolylethanol
3-(2-Hydroxyethyl)indole 97%
Color alcohol
NSC 3884
3-(2-Hydroxyethyl)indole Vetec(TM) reagent grade, 97%
3-Indoleethanol
3-(2-Hydroxyethyl)indole
beta-3-Indolylethanol
2-(1H-Indol-3-yl)ethan-1-ol
beta-(3-Indole)ethanol
dl-Tryptophanol
Ethanol, 2-indol-3-yl-
Ethanol, 3-indolyl-
3-β-hydroxyethyl in-dole
β-indolylethylalcohol
3-(2-Hydroxyethyl)indole~2-(3-Indolyl)ethanol
beta-indol-3-ylethanol
Tryptophol (Indole-3-ethanol)
TRYPTOPHOL ULTRA-PURE 99.5%
Tryptophol,97%
3-(2-HYDROXYETHYL)INDOLE (TRYPTOPHOL)
Tryptophol, 3-Indoleethanol
TRYPTOPHOL(IEt)
3-(2-Hydroxyethyl)-1H-indole
Tryptophol, 2-(1H-Indol-3-yl)ethan-1-ol
Tryptophol, 97% 5GR
Indole-3-ethanol (Tryptophol),beta-3-Indolylethanol
3-Indoleethanol>
ryptophol
Tryptopho
?-indol-3-ylethanol
INDOLE-3-ETHANOL
B-3-INDOLYLETHANOL
BETA-3-INDOLYLETHANOL
3-INDOLEETHANOL
2-(1H-INDOL-3-YL)ETHAN-1-OL
3-(2-HYDROXYETHYL)INDOLE
IEA
Indoleethanol
Tryptophol (6CI)
DK803
526-55-6
Indoles
Simple Indoles
Heterocyclic Building Blocks
Building Blocks
Heterocyclic Compounds
Indoles
Simple Indoles