ChemicalBook >> CAS DataBase List >>2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE

CAS No.
905973-89-9
Chemical Name:
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
Synonyms
K733;CS-713;CGK733;CGK 733, >=98%;CGK-733; CGK 733;ATM/ATR Kinase Inhibitor;ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem;2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE;2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE USP/EP/BP;α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
CBNumber:
CB0802213
Molecular Formula:
C23H18Cl3FN4O3S
Molecular Weight:
555.84
MDL Number:
MFCD09038682
MOL File:
905973-89-9.mol
MSDS File:
SDS
Modify Date:2022-12-21 16:56:50

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE Properties

storage temp. Sealed in dry,2-8°C
solubility ≥27.8 mg/mL in DMSO; insoluble in H2O; ≥5.55 mg/mL in EtOH with gentle warming and ultrasonic
form Pale yellow solid
FDA UNII L3DGZ99QYM

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 118501 ATM/ATR Kinase Inhibitor 905973-89-9 5mg $294 2023-01-07 Buy
Cayman Chemical 16242 CGK733 ≥98% 905973-89-9 5mg $50 2023-01-06 Buy
Cayman Chemical 16242 CGK733 ≥98% 905973-89-9 25mg $135 2023-01-06 Buy
Cayman Chemical 16242 CGK733 ≥98% 905973-89-9 1mg $35 2021-12-16 Buy
Cayman Chemical 16242 CGK733 ≥98% 905973-89-9 10mg $79 2023-01-06 Buy
Product number Packaging Price Buy
118501 5mg $294 Buy
16242 5mg $50 Buy
16242 25mg $135 Buy
16242 1mg $35 Buy
16242 10mg $79 Buy

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE Chemical Properties,Uses,Production

Uses

Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases mediate the DNA damage response pathway in cells upon encounter with genotoxic agents. Their signaling can activate cell cycle arrest, DNA repair, induction of premature senescence, and cell death. Inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents. CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death. Human cancer cell lines exposed to both caffeine and CGK733 demonstrate a rapid decline in cyclin D1 protein levels and a reduction in retinoblastoma protein levels, which leads to the inhibition of their proliferation.

Uses

CGK733 is a noted ataxia telangiectasia-mutated (ATM) protein/kinase inhibitor. Cell proliferation inhibitor and anticancer agent.

Biological Activity

Originally defined as a selective inhibitor of ATR and ATM kinases that reverses senescence in human BJ and HMEC cells. Decreases p21 CIP1 levels in senescent with no effect on p53 and Bcl-2 family members.

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31339 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29922 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22973 58
Chongqing Chemdad Co., Ltd
+undefined-86-13650506873 +undefined-86-13650506873 sales@chemdad.com China 39915 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551611 +8615751773523 contact@trustwe.com China 4880 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 727 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 Service@dideu.com China 29991 58
Henan Alfa Chemical Co., Ltd
+8618339805032 alfa4@alfachem.cn China 14275 58
InvivoChem
+1-708-3101919 sales@invivochem.net United States 6395 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+8617767106207 sales@molcore.com China 49756 58

View Lastest Price from 2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE pictures 2019-07-06 2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
905973-89-9
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE Spectrum

2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE CGK733 A-PHENYL-N-[2,2,2-TRICHLORO-1-[[[(4-FLUORO-3-NITROPHENYL)AMINO]THIOXOMETHYL]AMINO]ETHYL]BENZENEACETAMIDE α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide Benzeneacetamide, α-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]- alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide CGK 733 CGK 733 alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide CGK 733, >=98% ATM/ATR Kinase Inhibitor CS-713 CGK-733; CGK 733 ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem K733 2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE USP/EP/BP 905973-89-9 C23H18Cl3FN4O3S Inhibitors