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iRucaparib-AP6

iRucaparib-AP6 structure

CAS No.: 2410557-00-3

Chemical Name:: iRucaparib-AP6

Synonyms: iRucaparib-AP6;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[22-[4-(8-fluoro-3,4,5,6-tetrahydro-6-oxo-1H-pyrrolo[4,3,2-ef][2]benzazepin-2-yl)phenyl]-21-methyl-3,6,9,12,15,18-hexaoxa-21-azadocos-1-yl]amino]-

CBNumber:: CB08037518

Molecular Formula:: C46H55FN6O11

Molecular Weight:: 886.96

MDL Number:

MOL File:: 2410557-00-3.mol

Last updated:2025-04-18 09:51:30

Product description	Number	Pack Size	Price
iRucaparib-AP6 98.06%	CS-0109959	1mg	$550
iRucaparib-AP6 98.06%	CS-0109959	5mg	$1650
iRucaparib-AP6 98.06%	CS-0109959	10mg	$2850

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iRucaparib-AP6 Properties

Boiling point	1057.6±65.0 °C(Predicted)
Density	1.331±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 50 mg/mL (56.37 mM)
form	Solid
pka	10.74±0.40(Predicted)
color	Light yellow to yellow

iRucaparib-AP6 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0109959	iRucaparib-AP6 98.06%	2410557-00-3	1mg	$550	2021-12-16	Buy
ChemScene	CS-0109959	iRucaparib-AP6 98.06%	2410557-00-3	5mg	$1650	2021-12-16	Buy
ChemScene	CS-0109959	iRucaparib-AP6 98.06%	2410557-00-3	10mg	$2850	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0109959	1mg	$550	Buy
CS-0109959	5mg	$1650	Buy
CS-0109959	10mg	$2850	Buy

iRucaparib-AP6 Chemical Properties,Uses,Production

Uses

iRucaparib-AP6 is a highly efficient and specific PROTAC PARP1 degrader. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1].

IC 50

PARP1: 82 nM (DC₅₀)

References

[1] Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2

iRucaparib-AP6 Preparation Products And Raw materials

Raw materials

Preparation Products

iRucaparib-AP6 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29757	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5929	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9835	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29641	58
Biosynth Biological Technology (Suzhou) Co Ltd	51288865780	sales@biosynth.com	China	6051	58
Tianjin Baibei Biotechnology Co., Ltd.	15302170631		CHINA	166	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58
Biosynth Biological Technology (Suzhou) Co Ltd	58
Tianjin Baibei Biotechnology Co., Ltd.	58

iRucaparib-AP6 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[22-[4-(8-fluoro-3,4,5,6-tetrahydro-6-oxo-1H-pyrrolo[4,3,2-ef][2]benzazepin-2-yl)phenyl]-21-methyl-3,6,9,12,15,18-hexaoxa-21-azadocos-1-yl]amino]- 2410557-00-3