ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-

CAS No.
1402452-10-1
Chemical Name:
Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
Synonyms
hSMG-1 inhibitor 11e;hSMG 1 inhibitor 11e,hSMG1 inhibitor 11e;Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
CBNumber:
CB08097541
Molecular Formula:
C26H27N7O3S
Molecular Weight:
517.6
MDL Number:
MOL File:
1402452-10-1.mol
Last updated:2024-10-30 20:13:01

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- Properties

storage temp. 4°C, away from moisture and light
solubility DMSO : 50 mg/mL (96.60 mM; Need ultrasonic)
form Solid
color White to light yellow

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- Chemical Properties,Uses,Production

Biological Activity

HSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with IC50 value <0.05 nM. hSMG-1 inhibitor 11e exhibits 900-fold selectivity for hSMG-1 over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50 of 61 nM and 92 nM) and CDK1/CDK2 (IC50 of 32 μM and 7.1 μM).

in vitro

HSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment.

target

mTOR

45 nM (IC 50 )

PI3Kα

61 nM (IC 50 )

PI3Kγ

92 nM (IC 50 )

CDK1

32 μM ( IC 50 )

CDK2

7.1 μM (IC 50 )

hSMG-1

<0.05 nM (IC 50 )

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 999 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29774 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24649 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 cb5@aikonchem.com China 10528 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 hanfangpharma@126.com China 30962 58

View Lastest Price from Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
hSMG-1 inhibitor 11e pictures 2024-10-30 hSMG-1 inhibitor 11e
1402452-10-1
US $157.00-488.00 / mg 98.84% 10g TargetMol Chemicals Inc.

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- Spectrum

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- hSMG-1 inhibitor 11e hSMG 1 inhibitor 11e,hSMG1 inhibitor 11e 1402452-10-1 C26H27N7O3S