Pomalidomide-PEG4-NH2 hydrochloride
- CAS No.
- 2331259-45-9
- Chemical Name:
- Pomalidomide-PEG4-NH2 hydrochloride
- Synonyms
- HCl NH2-PEG4-CH2CO-Poma;Pomalidomide-PEG4-NH2 hydrochloride;Pomalidomide-amino-PEG4-NH2 (hydrochloride);14-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide hydrochloride;14-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecan-1-amide hydrochloride
- CBNumber:
- CB08361794
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Pomalidomide-PEG4-NH2 hydrochloride price
Pomalidomide-PEG4-NH2 hydrochloride Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG4-NH2 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG4-NH2 hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3725 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
SuZhou Medinoah Co.,LTD. | 0512-0512-69561983 13914027025 | he_qf@medinoah.com | China | 3445 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1304 | 58 |
Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 9957 | 58 |
Suzhou origin Specialty Chemicals Co., Ltd | 17701559125 | jiaoshangjun@origsc.com | China | 1786 | 58 |
View Lastest Price from Pomalidomide-PEG4-NH2 hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | Pomalidomide-PEG4-NH2 hydrochloride
2331259-45-9
|
US $0.00 / mg | 100mg | >99.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
- Pomalidomide-PEG4-NH2 hydrochloride
2331259-45-9
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.