Temoporfin
- CAS No.
- 122341-38-2
- Chemical Name:
- Temoporfin
- Synonyms
- EF 9;MTHPC;Foslip;Fosgel;Foscan;Fospeg;KW2345;Foslipos;m-TrTHPC;temoporfin
- CBNumber:
- CB0855310
- Molecular Formula:
- C44H32N4O4
- Molecular Weight:
- 680.75
- MDL Number:
- MFCD00867835
- MOL File:
- 122341-38-2.mol
| Melting point | >250 °C |
|---|---|
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Purple |
| NCI Dictionary of Cancer Terms | temoporfin |
| FDA UNII | FU21S769PF |
| NCI Drug Dictionary | temoporfin |
| ATC code | L01XD05 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Temoporfin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17333 | Temoporfin ≥95% | 122341-38-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17333 | Temoporfin ≥95% | 122341-38-2 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 17333 | Temoporfin ≥95% | 122341-38-2 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 17333 | Temoporfin ≥95% | 122341-38-2 | 25mg | $533 | 2024-03-01 | Buy |
| TRC | T017350 | Temoporfin,~90% | 122341-38-2 | 5mg | $110 | 2021-12-16 | Buy |
Temoporfin Chemical Properties,Uses,Production
Description
Temoporphin, a second generation photosensitizer, was launched in UK for the photodynamic therapy (PDT) of advanced head and neck cancers. This porphyrin derivative can be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin, that has selectively accumulated in cancer tissues. The resulting generation of highly reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively high complete and partial response rates in head and neck cancers, with higher response rates generally observed with higher light dose. Temoporphin is well-tolerated and does not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity and pain at the injection site.
Originator
Quanta Nova (UK)
Uses
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.
Uses
Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and through light activation and oxygen radical formation, it leads to necrosis and cell death.
Definition
ChEBI: Temoporfin is a member of chlorins. It has a role as a photosensitizing agent.
brand name
Foscan
Temoporfin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3791 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
View Lastest Price from Temoporfin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Temoporfin
122341-38-2
|
US $0.00-0.00 / KG | 5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-10 | Temoporfin
122341-38-2
|
US $3.00 / ASSAYS | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Temoporfin
122341-38-2
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- Temoporfin
122341-38-2
- US $3.00 / ASSAYS
- 99%
- Career Henan Chemical Co