gemeprost
- CAS No.
- 64318-79-2
- Chemical Name:
- gemeprost
- Synonyms
- D02073;Cergem;ONO 802;Carprost;Cervagem;SC 37681;Cervageme;gemeprost;Preglandin;Preglandin (tn)
- CBNumber:
- CB0875558
- Molecular Formula:
- C23H38O5
- Molecular Weight:
- 394.548
- MDL Number:
- MFCD00867892
- MOL File:
- 64318-79-2.mol
- MSDS File:
- SDS
| Boiling point | 438.73°C (rough estimate) |
|---|---|
| Density | 1.0380 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| pka | 13.84±0.60(Predicted) |
| FDA UNII | 45KZB1FOLS |
| ATC code | G02AD03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H332-H360-H301-H312 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P363-P501 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
gemeprost price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G305040 | Gemeprost | 64318-79-2 | 5mg | $2810 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002815 | GEMEPROST 95.00% | 64318-79-2 | 500ML | $4138.37 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002815 | GEMEPROST 95.00% | 64318-79-2 | 5ML | $787.71 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 18648 | Gemeprost | 64318-79-2 | 5mg | $950 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002815 | GEMEPROST 95.00% | 64318-79-2 | 100ML | $2365.44 | 2021-12-16 | Buy |
gemeprost Chemical Properties,Uses,Production
Description
Gemeprost, a metabolically stabilized analog of PGE1, has been demonstrated to reliably induce termination of early pregnancy when administered as a vaginal suppository. Its effect is presumably due to both uterine contraction and rapid decline of steroid hormone levels. Minimal side effects have been reported.
Originator
Ono (Japan)
Uses
Prostaglandin.
Uses
Gemeprost is an analogue of Prostaglandin (P838600). Gemeprosts, similarly to Nitric Oxide donors, induce uterine cervical dilation and are used before surgical termination of pregnancy.
Definition
ChEBI: Gemeprost is an aliphatic alcohol.
Manufacturing Process
Synthesis of 9-oxo-1α,15α-bis-(2-tetrahydropyranyloxy)-16,16-dimethylprosta-trans-2, trans-13-dienoic acid: 4 g of ethyl 9α-hydroxy-11α15α-bis-(2-
tetrahydropyranyloxy)-16,16-dimethyl-prosta-trans-2,trans-13-dienoate were
dissolved in 130 ml of a mixture of ethanol-water (3:1), mixed with 3.9 g of
potassium hydroxide and stirred at 25°C for 2 hours. The reaction mixture
was acidified with aqueous solution of oxalic acid to pH 5, and diluted with
100 ml of water, extracted with ethyl acetate. The extracts were washed with
water, dried over sodium sulfate and concentrated under reduced pressure to
obtain 3.88 g of 9α-hydroxy-11α,15α-bis-(2-tetrahydropyranyloxy)-16,16-
dimethyl-prosta-trans-2,trans-13dienoic acid.
The obtained compound 2.46 g were dissolved in 72 ml of diethyl ether and
stirred at 3°C. To which a solution of manganese sulfate (15 g), 3.1 g of
chromium trioxide, 72 ml of water and 3.5 ml of sulfuric acid was added. After
stirring for 3.5 hours at 3°C, extracted with diethyl ether. The organic layer
was washed with water, dried over sodium sulfate and concentrated under
reduced pressure. The residue was purified by column chromatography on
silica gel using ethyl acetate-benzene (1:1) as eluent to give 2.35 g of the
title compound.
Synthesis of 16,16-dimethyl-trans-δ2-PGE1: 2.35 g of the bistetrahydropyranyl ether were dissolved in 6 ml of tetrahydrofuran and 60 ml
of 65%-acetic acid aqueous solution and the solution stirred at 60°C to 70°C
for 20 minutes. The reaction mixture was extracted with ethyl acetate, and
the organic layer was washed with water, dried and concentrated under
reduced pressure. The residue was purified by column chromatography on
silica gel using ethyl acetate-cyclohexane (2:3) as eluent to yield 270 mg of
the title compound.
brand name
CERVAGEM
Therapeutic Function
Prostaglandin, Cervical softener
gemeprost Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
