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clofedanol

CAS No.
791-35-5
Chemical Name:
clofedanol
Synonyms
Dencyl;clofedano;Tussistop;clofedanol;Calmotusin;NSC 113595;Chlofedanol;Clophedianol;CHLOPHENDIANOL;Clophedianol base
CBNumber:
CB0875699
Molecular Formula:
C17H20ClNO
Molecular Weight:
289.7998
MDL Number:
MFCD00866840
MOL File:
791-35-5.mol
Last updated:2023-05-04 17:34:42

clofedanol Properties

Melting point 120°
Boiling point 429.8±45.0 °C(Predicted)
Density 1.148±0.06 g/cm3(Predicted)
pka 13.03±0.29(Predicted)
CAS DataBase Reference 791-35-5
FDA UNII 42C50P12AP
ATC code R05DB10

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Toxicity LD50 i.v. in mice: 70 mg/kg (Lorenz)

clofedanol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
IsoSciences 13420 Chlophedianol-[13C6] ≥98% 791-35-5 1mg $217 2021-12-16 Buy
American Custom Chemicals Corporation API0009164 CHLOPHEDIANOL 95.00% 791-35-5 250MG $727.65 2021-12-16 Buy
American Custom Chemicals Corporation API0009164 CHLOPHEDIANOL 95.00% 791-35-5 1G $825.3 2021-12-16 Buy
Product number Packaging Price Buy
13420 1mg $217 Buy
API0009164 250MG $727.65 Buy
API0009164 1G $825.3 Buy

clofedanol Chemical Properties,Uses,Production

Originator

Detigon,Bayer,W. Germany,1958

Uses

(±)-Chlophedianol is an inhalation eutectic compound, used for treatment of respiratory diseases.Also, used in preparation of Deuterated morphine derivatives useful in treatment of pain or as as antitussive agents with reduced risk of possibility of drug abuse.

Definition

ChEBI: Clofedanol is a diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. It has a role as an antitussive. It is a diarylmethane and a tertiary amino compound. It is a conjugate base of a clofedanol(1+).

Manufacturing Process

This compound may be produced by reacting o-chlorobenzophenone with acetonitrile in the presence of sodium amide or another strongly basic condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is subsequently dimethylated with an agent such as methyl sulfate to provide the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol.

Therapeutic Function

Antitussive

clofedanol Preparation Products And Raw materials

clofedanol Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3911 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
changzhou huayang technology co., ltd
+8615250961469 2571773637@qq.com China 9821 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923 1026@dideu.com China 9602 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
XiaoGan ShenYuan ChemPharm co,ltd 0712-0712-2580635 15527768850 1791901229@qq.com China 8850 52
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-83725681-603 China 4505 50

View Lastest Price from clofedanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
clofedanol USP/EP/BP pictures 2021-06-01 clofedanol USP/EP/BP
791-35-5
US $1.10 / g 1g 99.9% 100Tons min Dideu Industries Group Limited
Clofedanol   pictures 2020-04-25 Clofedanol
791-35-5
US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd
clofedanol pictures 2019-07-14 clofedanol
791-35-5
US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co
  • Clofedanol   pictures
  • Clofedanol
    791-35-5
  • US $0.01-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
  • clofedanol pictures
  • clofedanol
    791-35-5
  • US $8.80 / KG
  • 97%-99%
  • Career Henan Chemical Co
1-(2-chlorophenyl)-3-dimethylamino-1-phenylpropan-1-ol clofedanol clofedano CHLOPHENDIANOL 1-o-Chlorophenyl-1-phenyl-3-dimethylamino-1-propanol 1-o-Chlorophenyl-3-dimethylamino-1-phenylpropan-1-ol 1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol 1-Phenyl-1-o-chlorophenyl-3-(dimethylamino)-1-propanol 2-Chloro-α-(2-dimethylaminoethyl)benzhydrol Benzenemethanol, 2-chloro-α-[2-(dimethylamino)ethyl]-α-phenyl- Benzhydrol, 2-chloro-α-[2-(dimethylamino)ethyl]- (6CI, 7CI, 8CI) Calmotusin NSC 113595 Tussistop α-(Dimethylaminoethyl)-o-chlorobenzhydrol Chlophedianol (base and/or unspecified salts) CLOFEDANOL(CHLOPHEDIANOL) Chlofedanol .alpha.-(Dimethylaminoethyl)-o-chlorobenzhydrol 2-Chloro-.alpha.-(2-dimethylaminoethyl)benzhydrol Benzenemethanol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]-.alpha.-phenyl- Benzhydrol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]- Clophedianol base Dencyl Clophedianol Chlophedianol-13C6 clofedanol USP/EP/BP 791-35-5