ChemicalBook >> CAS DataBase List >>4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester structure

CAS No.: 2410512-38-6

Chemical Name:: 4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester

Synonyms: JADA82;JQKD-82;LSD1-IN-26;4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester

CBNumber:: CB08964052

Molecular Formula:: C27H40N4O5

Molecular Weight:: 500.64

MDL Number:

MOL File:: 2410512-38-6.mol

Last updated:2023-03-31 09:12:59

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4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester Properties

Boiling point	652.9±55.0 °C(Predicted)
Density	1.113±0.06 g/cm3(Predicted)
pka	8.38±0.28(Predicted)

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester Chemical Properties,Uses,Production

Description

JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently

target

KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM)

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester Suppliers

Global( 18)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4196	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9838	58
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	chaolaichem@foxmail.com	China	9242	58
Fujian boshi pharmaceutical technology co. LTD	18120708884	393612455@qq.com	China	255	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56039	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Beijing Stronger Science Co., Ltd.	0531-88924771 15614660963	elsa.hang@strongerscience.com	China	10624	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
Fujian boshi pharmaceutical technology co. LTD	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
DC Chemicals	58
Beijing Stronger Science Co., Ltd.	58

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester JQKD-82 JADA82 LSD1-IN-26 2410512-38-6