Fungichromin
- CAS No.
- 6834-98-6
- Chemical Name:
- Fungichromin
- Synonyms
- Lagosin;Cogomycin;Fungichromin;Lagosin【antibiotic】;(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one;Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-
- CBNumber:
- CB0904201
- Molecular Formula:
- C35H58O12
- Molecular Weight:
- 670.83
- MDL Number:
- MOL File:
- 6834-98-6.mol
- MSDS File:
- SDS
| Melting point | 157-162° (dec) |
|---|---|
| alpha | D20 -227.7° (c = 0.53 in DMF) |
| Boiling point | 914.0±65.0 °C(Predicted) |
| Density | 1.196±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 12.77±0.70(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | 1JB340D58S |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): 1624 orally; 33.3 i.p. (Umezawa, Tanaka) |
|---|
Fungichromin price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20600 | Lagosin ≥95% | 6834-98-6 | 1mg | $352 | 2024-03-01 | Buy |
| Cayman Chemical | 20600 | Lagosin ≥95% | 6834-98-6 | 5mg | $1229 | 2024-03-01 | Buy |
| ApexBio Technology | C3526 | Lagosin | 6834-98-6 | 5mg | $1384 | 2021-12-16 | Buy |
| ApexBio Technology | C3526 | Lagosin | 6834-98-6 | 1mg | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016850 | FUNGICHROMIN 95.00% | 6834-98-6 | 5MG | $504.17 | 2021-12-16 | Buy |
Fungichromin Chemical Properties,Uses,Production
Uses
Lagosin is a pentaene antifungal produced by Streptomyces, first isolated in 1958 by researchers at MIT in the USA. The discovery was soon followed by several independent isolations as lagosin and cogomyin. Initially these metabolites were thought to be isomeric, but Pandey and colleagues at NCI definitively demonstrated they were identical. Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides. Lagosin exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols.
Definition
ChEBI: Fungichromin is a macrolide and an antibiotic antifungal drug.
Biological Activity
lagosin, a polyene macrolide antibiotic, has first been extracted from an isolate of a streptomyces species present in a sample of soil collected in lagos, nigeria [1]. it has been reported that the three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, showed some stereochemical differences at one or more centers [1].lagosin was the most polar member of the filipin family of fungicides with broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols. the antibiotic lagosin, which appeared to be identical to, or a stereoisomer of, fungichromin, and was very similar in structure to the filipins [2]. the equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin iil > amphotericin b > nystatin > lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes [2].
References
[1] pandey r c, guenther e c, aszalos a a, et al. physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin[j]. the journal of antibiotics, 1982, 35(8): 988-996.
[2] bittman r, fischkoff s a. fluorescence studies of the binding of the polyene antibiotics filipin iii, amphotericin b, nystatin, and lagosin to cholesterol[j]. proceedings of the national academy of sciences, 1972, 69(12): 3795-3799.
Fungichromin Preparation Products And Raw materials
Raw materials
Preparation Products
Fungichromin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15744 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 | sales@sunlidabio.com | China | 3750 | 55 |
| Raw material medicin reagent co.,Ltd | 025-57798860 | sales@njromanme.com | China | 4534 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |