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amiphenazole

CAS No.
490-55-1
Chemical Name:
amiphenazole
Synonyms
Daftazol;Daptazile;Amifenazol;Phenamizol;Phenamizole;Amifenazole;Amiphenazol;amiphenazole;Amifenazol [inn-spanish];2,4-Diamino-5-phenylthiazole
CBNumber:
CB0909615
Molecular Formula:
C9H9N3S
Molecular Weight:
191.25
MDL Number:
MFCD00128273
MOL File:
490-55-1.mol
Last updated:2023-05-04 17:34:39

amiphenazole Properties

Melting point 163.5°C (rough estimate)
Boiling point 413.3±25.0 °C(Predicted)
Density 1.1906 (rough estimate)
refractive index 1.5300 (estimate)
pka 5.12±0.10(Predicted)
FDA UNII 7ZJ8PWY0XD

amiphenazole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Crysdot CD11117196 5-Phenylthiazole-2,4-diamine 97% 490-55-1 1g $90 2021-12-16 Buy
Crysdot CD11117196 5-Phenylthiazole-2,4-diamine 97% 490-55-1 5g $270 2021-12-16 Buy
Crysdot CD11117196 5-Phenylthiazole-2,4-diamine 97% 490-55-1 10g $450 2021-12-16 Buy
Crysdot CD11117196 5-Phenylthiazole-2,4-diamine 97% 490-55-1 25g $880 2021-12-16 Buy
Product number Packaging Price Buy
CD11117196 1g $90 Buy
CD11117196 5g $270 Buy
CD11117196 10g $450 Buy
CD11117196 25g $880 Buy

amiphenazole Chemical Properties,Uses,Production

Originator

Aamphisol,RJR

Definition

ChEBI: Amiphenazole is a member of thiazoles.

Manufacturing Process

Thiourea reacted with α-bromophenylacetonitrile and as a result of this reaction 2-(cyanophenylmethyl)isothiourea was obtained.
By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5- phenylthiazole (amiphenazol) was produced.

Therapeutic Function

Respiratory stimulant, Barbiturate antagonist, Morphine antagonist

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005

Purification Methods

The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.]

amiphenazole Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 4112 55
Candia Thamtech Company Limited 0371-86615086 18203638366 0371-86159066 13526786601 China 2017 60
Tianjing Geneston Bio-tech Co.,Ltd. 022-60131465 18920720807 zishan_1986@163.com China 742 58
Shanghai Haohong Scientific Co., Ltd. 400-400-8210725 malulu@leyan.com China 40041 58
amiphenazole Amifenazole Daftazol Phenamizol Phenamizole 2,4-Diamino-5-phenylthiazole 2,4-Thiazolediamine, 5-phenyl- 6020-54-8 (Mono-hydrobromide) 942-31-4 (Mono-hydrochloride) Amifenazol Amifenazol [inn-spanish] Amiphenazol 5-phenylthiazole-2,4-diaMine 5-PHENYL-2,4-THIAZOLEDIAMINE 5-phenyl-1,3-thiazole-2,4-diamine Daptazile 490-55-1