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Dhodh-IN-16

Dhodh-IN-16 structure

CAS No.: 2511248-11-4

Chemical Name:: Dhodh-IN-16

Synonyms: DHODH-IN-16;DNA/RNA Synthesis,inhibit,Dihydroorotate Dehydrogenase,Inhibitor,antiproliferative,DHODH IN 16,DHODH,DHODHIN16;6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 6-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-7-fluoro-4-(1-methylethyl)-2-(2-methylphenyl)-

CBNumber:: CB09441217

Molecular Formula:: C24H25FN4O3

Molecular Weight:: 436.48

MDL Number:

MOL File:: 2511248-11-4.mol

Last updated:2023-05-21 10:59:17

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Dhodh-IN-16 Properties

Boiling point	602.6±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (229.11 mM; Need ultrasonic)
pka	13.54±0.10(Predicted)

Dhodh-IN-16 Chemical Properties,Uses,Production

Biological Activity

DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1]. DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1].

References

[1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1.

Dhodh-IN-16 Preparation Products And Raw materials

Raw materials

Preparation Products

Dhodh-IN-16 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9664	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Qi Qi hang Biotechnology Co., Ltd.	15870833005	2232044025@qq.com	China	8208	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5019	58
Shanghai jerryxing Biomedical Technology Co., Ltd	17721492509	643638326@qq.com	China	5347	58

Supplier	Advantage
Finetech Industry Limited	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Finetech Industry Limited	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Qi Qi hang Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
Shanghai jerryxing Biomedical Technology Co., Ltd	58

6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin-1(2H)-one DHODH-IN-16 DNA/RNA Synthesis,inhibit,Dihydroorotate Dehydrogenase,Inhibitor,antiproliferative,DHODH IN 16,DHODH,DHODHIN16 1(2H)-Isoquinolinone, 6-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-7-fluoro-4-(1-methylethyl)-2-(2-methylphenyl)- 2511248-11-4