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Pyroxamide

CAS No.
382180-17-8
Chemical Name:
Pyroxamide
Synonyms
NSC 696085;Pyroxamide;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide ISO 9001:2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
CBNumber:
CB0950394
Molecular Formula:
C13H19N3O3
Molecular Weight:
265.31
MDL Number:
MFCD13194970
MOL File:
382180-17-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Pyroxamide Properties

storage temp. -20°C
solubility DMSO: soluble10mg/mL (clear solution)
form powder
color white to beige
NCI Dictionary of Cancer Terms pyroxamide
FDA UNII 12N86DSS23
NCI Drug Dictionary pyroxamide

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

Pyroxamide price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0296 Pyroxamide ≥97% (HPLC) 382180-17-8 5mg $114 2024-03-01 Buy
Sigma-Aldrich SML0296 Pyroxamide ≥97% (HPLC) 382180-17-8 25mg $407 2022-05-15 Buy
Cayman Chemical 13870 Pyroxamide ≥95% 382180-17-8 5mg $61 2024-03-01 Buy
Cayman Chemical 13870 Pyroxamide ≥95% 382180-17-8 10mg $107 2024-03-01 Buy
Cayman Chemical 13870 Pyroxamide ≥95% 382180-17-8 25mg $250 2024-03-01 Buy
Product number Packaging Price Buy
SML0296 5mg $114 Buy
SML0296 25mg $407 Buy
13870 5mg $61 Buy
13870 10mg $107 Buy
13870 25mg $250 Buy

Pyroxamide Chemical Properties,Uses,Production

Description

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Uses

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes imp licated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Uses

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Uses

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Definition

ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.

storage

-20°C

References

[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.

Pyroxamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Hebei Duling International Trade Co. LTD
+8618032673083 sales05@hbduling.cn China 15755 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58

View Lastest Price from Pyroxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyroxamide pictures 2022-11-23 Pyroxamide
382180-17-8
US $0.50 / kg 1kg 0.99 20 Hebei Duling International Trade Co. LTD
Pyroxamide pictures 2021-09-27 Pyroxamide
382180-17-8
US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Pyroxamide pictures 2019-12-23 Pyroxamide
382180-17-8
US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • Pyroxamide pictures
  • Pyroxamide
    382180-17-8
  • US $0.50 / kg
  • 0.99
  • Hebei Duling International Trade Co. LTD
  • Pyroxamide pictures
  • Pyroxamide
    382180-17-8
  • US $1.10 / g
  • 99.00%
  • Dideu Industries Group Limited
  • Pyroxamide pictures
  • Pyroxamide
    382180-17-8
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co
2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide PyroxaMide (NSC 696085) N1-Hydroxy-N8-3-pyridinyl-octanediamide N1-Hydroxy-N8-(pyridin-3-yl)octanediamide Octanediamide, N1-hydroxy-N8-3-pyridinyl- N-Hydroxy-N'-3-pyridinyloctanediamide Pyroxamide PYROXAMIDE, N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE 382180-17-8; NSC-696085; N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE; N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE; NSC696085; NSC 696085 n-hydroxy-n'-(pyridin-3-yl)octanediamide NSC 696085 Pyroxamide  Pyroxamide ISO 9001:2015 REACH HDAC1,inhibit,Apoptosis,Histone deacetylases,Pyroxamide,leukemia,HDAC,Inhibitor 382180-17-8