Encainide
- CAS No.
- 37612-13-8
- Chemical Name:
- Encainide
- Synonyms
- Encainide;Unii-sy3J0147nb;Encainide [inn:ban];Encainide USP/EP/BP;4-Methoxy-N-(2-(2-(1-Methylpiperidin-2-yl)ethyl)phenyl)benzaMide
- CBNumber:
- CB0969673
- Molecular Formula:
- C22H28N2O2
- Molecular Weight:
- 352.475
- MDL Number:
- MOL File:
- 37612-13-8.mol
- MSDS File:
- SDS
FDA UNII | SY3J0147NB |
---|---|
ATC code | C01BC08 |
Encainide Chemical Properties,Uses,Production
Description
Encainide is a membrane-active class I c agent with complex metabolism and clinical pharmacology , . To date, its effectiveness has been proved against ventricular arrhythmias.
Uses
Cardiac depressant (anti-arrhythmic.
Uses
Clinical use of encainide is primarily associated with the presence of serious ventricular tachycardia; however, like flecainide, it is also sufficiently effective for atrial arrhythmia and is used for natural occurrences.
Definition
ChEBI: Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of piperidines and a member of benzamides.
brand name
Enkaid (Bristol Labs).
World Health Organization (WHO)
The membrane-stabilizing antiarrhythmic agent encainide was introduced into medicine in the mid-1980's. The decision to delete the indications for patients with asymptomatic and less severe symptomatic ventricular arrhythmias was taken on the basis of the results of a trial (CAST study) that showed a two-fold increase in deaths in post-myocardiac patients taking encainide compared with the placebo group. (See also WHO comment for flecainide).
Side effects
Side effects include central nervous system activity.
Synthesis
Encainide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-benzamide (18.1.15), is synthesized by acylating 2-(1-methyl-2-piperidylethyl)aniline with 4- methoxybenzoic acid chloride. The chemical structure of encainide is substantially different than other local anesthetics and antiarrhythmics.
Encainide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9604 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29525 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 20000 | 58 |
Supplier | Advantage |
---|---|
Alchem Pharmtech,Inc. | 58 |
Career Henan Chemica Co | 58 |
Shaanxi Dideu Medichem Co. Ltd | 58 |
Dideu Industries Group Limited | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | 58 |
View Lastest Price from Encainide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-08-12 | Encainide USP/EP/BP
37612-13-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
- Encainide USP/EP/BP
37612-13-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited