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RG108

RG108
RG108 structure
CAS No.
48208-26-0
Chemical Name:
RG108
Synonyms
RG108 >98%;RG108/RG-108;N-Phthalyl-L-tryptophan;N-Phthaloyl-L-tryptophan;DNA Methyltransferase Inhibitor;RG108/DNA Methyltransferase Inhibitor/N-Phthalyl-L-tryptophan;(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-
CBNumber:
CB0972112
Molecular Formula:
C19H14N2O4
Formula Weight:
334.33
MOL File:
48208-26-0.mol

RG108 Properties

Melting point:
192-194℃
Boiling point:
606.0±50.0 °C(Predicted)
Density 
1.502±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: >10mg/mL
form 
powder
pka
3.62±0.10(Predicted)
color 
yellow
Sensitive 
Light Sensitive
CAS DataBase Reference
48208-26-0
SAFETY
  • Risk and Safety Statements
WGK Germany  3

RG108 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R8279 RG108 ≥98% (HPLC), powder 48208-26-0 10mg $210 2018-11-13 Buy
TCI Chemical P2023 N-Phthalyl-L-tryptophan >98.0%(HPLC)(T) 48208-26-0 50mg $129 2018-11-22 Buy
TCI Chemical P2023 N-Phthalyl-L-tryptophan >98.0%(HPLC)(T) 48208-26-0 200mg $386 2018-11-22 Buy
Alfa Aesar J64630 DNA Methyltransferase Inhibitor 48208-26-0 10mg $148 2018-11-13 Buy
Cayman Chemical 13302 RG-108 ≥98% 48208-26-0 5mg $49 2018-11-13 Buy

RG108 Chemical Properties,Uses,Production

Uses

DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.

Biological Activity

Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.

RG108 Preparation Products And Raw materials

Raw materials

Preparation Products


RG108 Suppliers

Global( 79)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2303 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com; China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
VDM Biochemicals 0330-2528181
0330-2528171 sales@vdmbio.com United States 510 64
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783;
+86 (531) 55696010 QQ 1762738062 sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market) China 1857 62

View Lastest Price from RG108 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-05 RG108/RG-108
48208-26-0
US $1.00 / KG 1KG 98% 20kg career henan chemical co

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