ChemicalBook
Chinese Japanese Germany Korea

Patupilone

Patupilone
Patupilone structure
CAS No.
152044-54-7
Chemical Name:
Patupilone
Synonyms
EPO 906A;atupilone;Patupilone;EPOTHILONE;Epothilone B;Epothilone B, >=98%;Epothilone B(EPO906);Patupilone(Epothilone B);Epothilone B(Patupilone);EPO906, EpoB, Patupilone
CBNumber:
CB0972824
Molecular Formula:
C27H41NO6S
Formula Weight:
507.68
MOL File:
152044-54-7.mol

Patupilone Properties

Melting point:
95-97°C
alpha 
D21 -35° (c = 0.7 in methanol)
Density 
1.136
storage temp. 
Store at -20°C
form 
White to off-white solid
color 
colorless
InChIKey
QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS DataBase Reference
152044-54-7

SAFETY

WGK Germany  3
HS Code  29419090

Patupilone price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E2656 (?)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) 152044-54-7 1mg $40.2 2018-11-13 Buy
Sigma-Aldrich 325001 Epothilone B, Synthetic 152044-54-7 1mg $130 2018-11-20 Buy
Cayman Chemical 10924 Epothilone B ≥95% 152044-54-7 5mg $396 2018-11-13 Buy
Cayman Chemical 10924 Epothilone B ≥95% 152044-54-7 1mg $88 2018-11-13 Buy
Sigma-Aldrich E2656 (?)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) 152044-54-7 5mg $123 2018-11-13 Buy

Patupilone Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

Uses

Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

Uses

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

Definition

ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).

Biological Activity

Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .

Patupilone Preparation Products And Raw materials

Raw materials

Preparation Products


Patupilone Suppliers

Global( 138)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22084 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20763 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32607 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6402 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24095 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20201 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8425 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19978 58
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5985 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512
+86-510-68873513 sales@cegchem.com China 1797 58

View Lastest Price from Patupilone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-27 Patupilone
152044-54-7
US $15.00 / KG 1KG 98% 1533716-785-6 career henan chemical co

152044-54-7(Patupilone)Related Search:


  • Epothilone B, >=98%
  • Patupilone(Epothilone B)
  • atupilone
  • 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-
  • EPO 906A
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
  • Epothilone B
  • Patupilone
  • ()-Epothilone B,EPO906, EpoB, Patupilone
  • EPO906, EpoB, Patupilone
  • Epothilone B(EPO906)
  • Epothilone B HOUSE STANDARD
  • 152044-54-7
  • Inhibitors
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Epothilone B(Patupilone)
  • (3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione
  • Epothilone B (EPO906, Patupilone)
  • EPOTHILONE
  • (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
  • Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Copyright 2017 © ChemicalBook. All rights reserved