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1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE structure
CAS No.
69304-37-6
Chemical Name:
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
Synonyms
TIPSCL;TIPDSICL2;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro;1,1,3,3-TETRAISOPROPYL-1,3-DICH;Bis(chlorodiisopropylsilyl) ether;1,3-DICHLOROTETRAISOPROPYLSILOXANE;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-;1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISIL
CBNumber:
CB1100268
Molecular Formula:
C12H28Cl2OSi2
Formula Weight:
315.43
MOL File:
69304-37-6.mol

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Properties

Boiling point:
70 °C0.5 mm Hg(lit.)
Density 
0.986 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.454(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
Specific Gravity
0.986
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
Sensitive 
Moisture Sensitive
BRN 
1934216
InChIKey
DDYAZDRFUVZBMM-UHFFFAOYSA-N
CAS DataBase Reference
69304-37-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H227-H290-H314-H318
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P501a-P210-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P390-P403+P235-P405-P406-P501-P280-P305+P351+P338-P310
Hazard Codes  C
Risk Statements  34
Safety Statements  26-27-28-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
10-21
Hazard Note  Corrosive
TSCA  No
HazardClass  8
PackingGroup  II
HS Code  29319090

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 337005 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% 69304-37-6 1g $57.3 2021-03-22 Buy
Sigma-Aldrich 337005 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% 69304-37-6 5g $129 2021-03-22 Buy
TCI Chemical D1608 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC) 69304-37-6 5g $100 2021-03-22 Buy
TCI Chemical D1608 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC) 69304-37-6 25g $300 2021-03-22 Buy
Alfa Aesar L11171 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97% 69304-37-6 1g $55.1 2021-03-22 Buy

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Physical properties

bp 70°C/0.5 mmHg; d 0.986 g cm?3.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).

Preparation

can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Preparation Products And Raw materials

Raw materials

Preparation Products


1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Suppliers

Global( 238)Suppliers
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
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View Lastest Price from 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-12 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
69304-37-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
69304-37-6
US $1.00 / KG 1KG 98% 1kg,5kg,100kg career henan chemical co

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