ChemicalBook >> CAS DataBase List >>1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE structure

CAS No.: 69304-37-6

Chemical Name:: 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

Synonyms: TIPSCL;1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE;TIPDSICL2;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;DK365;DK870;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro;1,1,3,3-TETRAISOPROPYL-1,3-DICH;Bis(chlorodiisopropylsilyl) ether

CBNumber:: CB1100268

Molecular Formula:: C12H28Cl2OSi2

Molecular Weight:: 315.43

MDL Number:: MFCD00009655

MOL File:: 69304-37-6.mol

MSDS File:: SDS

Last updated:2024-03-25 11:48:53

Request For Quotation

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Properties

Boiling point	70 °C0.5 mm Hg(lit.)
Density	0.986 g/mL at 25 °C(lit.)
refractive index	n20/D 1.454(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
form	Oil
color	Colourless
Specific Gravity	0.986
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	1934216
InChI	InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
InChIKey	DDYAZDRFUVZBMM-UHFFFAOYSA-N
SMILES	[Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C
CAS DataBase Reference	69304-37-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H290-H314

Precautionary statements

P280-P303+P361+P353-P305+P351+P338+P310

Hazard Codes

Risk Statements

Safety Statements

26-27-28-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

10-21

Hazard Note

Corrosive

TSCA

HazardClass

PackingGroup

HS Code

29319090

NFPA 704

	1
3		0

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	337005	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97%	69304-37-6	1g	$27.06	2024-03-01	Buy
Sigma-Aldrich	337005	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97%	69304-37-6	5g	$133	2024-03-01	Buy
TCI Chemical	D1608	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC)	69304-37-6	5g	$116	2024-03-01	Buy
TCI Chemical	D1608	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC)	69304-37-6	25g	$348	2024-03-01	Buy
Alfa Aesar	L11171	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%	69304-37-6	5g	$202	2024-03-01	Buy

Product number	Packaging	Price	Buy
337005	1g	$27.06	Buy
337005	5g	$133	Buy
D1608	5g	$116	Buy
D1608	25g	$348	Buy
L11171	5g	$202	Buy

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Physical properties

bp 70°C/0.5 mmHg; d 0.986 g cm?3.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Preparation

can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE synthesis

Synthesis of 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE from 1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Preparation Products And Raw materials

Raw materials

Silanol, 1,1-bis(1-methylethyl)- 1,1,3,3-TETRAISOPROPYLDISILOXANE

Preparation Products

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine (+)-3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)cytidine 3',5'-TIPS-5-Me-Uridine Adenosine, N-[bis(4-methoxyphenyl)phenylmethyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- 1-[3,5-O-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxaMide

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Suppliers

Global( 332)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hunan aslsen technology co.,ltd	+86-17397237530 +86-19313031929	aslsd@aslsen.com	China	128	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Zjartschem	+86-571-8723 8903 jocelynpan@zjarts.com	jocelynpan@zjarts.com	CHINA	993	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Hunan aslsen technology co.,ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Yunbio Tech Co.,Ltd.	58

View Lastest Price from 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	1,3-dichlorotetraisopropyldisiloxane 69304-37-6	US $0.00 / kg	1kg	99.9%	10tons/month	Hunan Aslisen Technology Co., Ltd
2024-02-06	1,3-Dichloro-1,1,3,3-Tetraisopropyldisiloxan 69304-37-6	US $0.00-0.00 / KGS	5KGS	97+%	10ton/year	Yunbio Tech Co.,Ltd.
2022-10-20	1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

1,3-dichlorotetraisopropyldisiloxane
69304-37-6
US $0.00 / kg
99.9%
Hunan Aslisen Technology Co., Ltd

1,3-Dichloro-1,1,3,3-Tetraisopropyldisiloxan
69304-37-6
US $0.00-0.00 / KGS
97+%
Yunbio Tech Co.,Ltd.

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
69304-37-6
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Spectrum

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)¹HNMR 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)IR 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)Raman 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)FT-IR

69304-37-6(1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE)Related Search:

1,1,1,3,3,5,5-HEPTAMETHYLTRISILOXANE 1,3-DIMETHYL-1,1,3,3-TETRAPHENYLDISILAZANE 1,1,3,3-TETRAMETHYL-1,3-DIETHOXYDISILOXANE 1,1,1-triethyl-3,3,3-trimethyldisiloxane 1,1,3,3,5,5-HEXAMETHYLTRISILOXANE

1,1,3,3-TETRAVINYLDIMETHYLDISILOXANE 1,1,3,3-TETRAISOPROPYLDISILOXANE 1,1,3,3-TETRAMETHYLDISILOXANE DIISOPROPYLCHLOROSILANE 1,3-DICHLOROTETRAMETHYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chlorodimethylsilane DIETHYLSILANE 1,1,3,3-TETRACYCLOPENTYLDICHLORODISILOXANE 1,3-dimethyldisiloxane

DIISOPROPYLSILANE METHYLETHYLCHLOROSILANE DIETHYLCHLOROSILANE

1of4

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANE 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 1,3-DICHLOROTETRAISOPROPYLSILOXANE 1,1,3,3-Tetraisopropyl-1,3-dichloropropanedisiloxane 1,3-Dichloro-1,1,3,3-tetraisopropylpropanedisiloxane 2,6-Dimethyl-3,5-dichloro-3,5-diisopropyl-4-oxa-3,5-disilaheptane Bis(chlorodiisopropylsilyl) ether 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane,96% 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane ,97% chloro-(chloro-dipropan-2-yl-silyl)oxy-dipropan-2-yl-silane 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL- 1,3-Dichloro-1,1,3,3-tetraisopropoxydisiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] Disiloxane, 1,3-dichloro-1,1,3,3-tetrakis(1-methylethyl)- chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane 1,3-Dichloro-1,1,3,3-tetrakis(prop-2-yl)disiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxae 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 96% 5ML 1,1,3,3-Tetraisopropyl-1,3-dichlorosiloxane 2,6-DiMethyl-3,5-dichloro 1,1,3,3-tetraisopropyldisiloxanylidene-dichloride 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxan 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISIL 1,1,3,3-Tetraisopropyl-1,3-dichlorodisiloxane 〔1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane〕 1,1,3,3-TETRAISOPROPYL-1,3-DICH JACS-69304-37-6 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane 97% 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane[HydroxylProtectingAgent]> 1,3-DICHLOROTETRAISOPROPYLDISILOXANE 1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE TIPSCL TIPDSICL2 chloro-[chloro(diisopropyl)silyl]oxy-diisopropyl-silane 1,3-Dichloro-1,1,3,3-tetrakis(1-methylethyl)disiloxane DK365 DK870 1,3-DICHLORO-1,1,3,3- TETRAISOPROPYLDISILOXANE TIPDSiCl2 1,3-dichloro-1,1,3,3-tetraisopropyldimethylsiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane（TIPSCI） 69304-37-6 C12H28Si2Cl2O CH32CH2SiClOSiClCHCH322 C12H28Cl2OSi2 CH32CH2SiClOClSiCHCH322 Protecting and Derivatizing Reagents Protection and Derivatization Synthetic Reagents Silicon-Based Protection & Derivatization Reagents (for Synthesis) Siloxanes Si-O Compounds Si (Classes of Silicon Compounds) Silicon Compounds (for Synthesis) Si-Cl Compounds Monochlorosilanes DNA / RNA Synthesis Protecting Agents for Hydroxyl Group (DNA/RNA Synthesis)