ZILPATEROL HYDROCHLORIDE
- CAS No.
- 119520-05-7
- Chemical Name:
- ZILPATEROL HYDROCHLORIDE
- Synonyms
- zilpaterol Solution, 100ppm;zilpa;RU-4217;RU-42173;trans-(±)-Zilpaterol;Zilpaterol HCl and Enantiomer;ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY);ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY);(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-
- CBNumber:
- CB11011688
- Molecular Formula:
- C14H19N3O2
- Molecular Weight:
- 261.32
- MDL Number:
- MFCD09033213
- MOL File:
- 119520-05-7.mol
- MSDS File:
- SDS
| Melting point | 123-126°C |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 13.39±0.60(Predicted) |
| Stability | Temperature Sensitive |
| CAS DataBase Reference | 119520-05-7 |
| FDA UNII | S384A1Y12J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H332-H372 |
| Precautionary statements | P260-P264-P270-P314-P501 |
| HS Code | 29339900 |
ZILPATEROL HYDROCHLORIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16484 | Zilpaterol ≥98% | 119520-05-7 | 1mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 16484 | Zilpaterol ≥98% | 119520-05-7 | 5mg | $149 | 2021-12-16 | Buy |
| Cayman Chemical | 16484 | Zilpaterol ≥98% | 119520-05-7 | 10mg | $280 | 2021-12-16 | Buy |
| TRC | Z430000 | Zilpaterol | 119520-05-7 | 2.5mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FZ156790 | Zilpaterol | 119520-05-7 | 5mg | $100 | 2021-12-16 | Buy |
ZILPATEROL HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
Zilpaterol is a β-Adrenergic agonist. Growth promotant.
Uses
Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.
Definition
ChEBI: Zilpaterol is a benzazepine.
Biological Activity
zilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes.
in vitro
previus study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
in vivo
fda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2].
References
[1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012).
[2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010).
ZILPATEROL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| TianJin Alta Scientific Co., Ltd. | 022-65378550-8551 | contact@altascientific.com | China | 2773 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10658 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55591 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Cato Research Chemicals Inc. | 020-81215950 4000-868-328 | customer@uwalab.com | United States | 10413 | 58 |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | shanpel@anpel.com.cn | China | 9614 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-400-8210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |