Canertinib dihydrochloride
- CAS No.
- 289499-45-2
- Chemical Name:
- Canertinib dihydrochloride
- Synonyms
- CI103;CI 103;CI-1033;Canertinib HCl;Canertinib 2HC;Canertinib.2HCL;CI1033 dihydrochloride;CI 1033 dihydrochloride;CI-1033 dihydrochloride;PD-183805 dihydrochloride
- CBNumber:
- CB11011729
- Molecular Formula:
- C24H27Cl3FN5O3
- Molecular Weight:
- 558.86
- MDL Number:
- MFCD09954112
- MOL File:
- 289499-45-2.mol
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| solubility | DMSO: >10mg/mL |
| form | solid |
| NCI Dictionary of Cancer Terms | canertinib dihydrochloride; CI-1033 |
| FDA UNII | ICJ93X8X90 |
| NCI Drug Dictionary | canertinib dihydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | UC6316110 |
Canertinib dihydrochloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7249 | CI-1033 ≥98% (HPLC) | 289499-45-2 | 5mg | $86.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7249 | CI-1033 ≥98% (HPLC) | 289499-45-2 | 25mg | $351 | 2024-03-01 | Buy |
| Cayman Chemical | 12076 | Canertinib (hydrochloride) ≥98% | 289499-45-2 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 12076 | Canertinib (hydrochloride) ≥98% | 289499-45-2 | 10mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 12076 | Canertinib (hydrochloride) ≥98% | 289499-45-2 | 25mg | $134 | 2024-03-01 | Buy |
Canertinib dihydrochloride Chemical Properties,Uses,Production
Uses
CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
Uses
Canertinib Dihydrochloride is a water-soluble, EGFR, HER2, and ErbB-4 tyrosine kinase inhibitor.
Uses
The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.Canertinib dihydrochloride is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib dihydrochloride also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.
storage
Store at -20°C
Canertinib dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
View Lastest Price from Canertinib dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-09 | Canertinib dihydrochloride
289499-45-2
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2022-02-25 | Canertinib dihydrochloride
289499-45-2
|
US $23.00 / KG | 1KG | 99% | 1 ton | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | Canertinib dihydrochloride
289499-45-2
|
US $19.00 / Kg/Bag | 1Kg/Bag | 99% | 20tons | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- Canertinib dihydrochloride
289499-45-2
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Canertinib dihydrochloride
289499-45-2
- US $23.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Canertinib dihydrochloride
289499-45-2
- US $19.00 / Kg/Bag
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd