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Myristic acid

Chemical properties Application Preparation Toxicity Use limit
Myristic acid
Myristic acid
CAS No.
544-63-8
Chemical Name:
Myristic acid
Synonyms
14:0;C14:0;NAA104;NAA142;Crodacid;emery655;NSC 5028;Emery 655;Emery 654;EdenorC14
CBNumber:
CB1104862
Molecular Formula:
C14H28O2
Formula Weight:
228.37
MOL File:
544-63-8.mol

Myristic acid Properties

Melting point:
52-54 °C(lit.)
Boiling point:
250 °C100 mm Hg(lit.)
Density 
0.862
FEMA 
2764 | MYRISTIC ACID
refractive index 
nD60 1.4305; nD70 1.4273
Flash point:
>230 °F
storage temp. 
−20°C
solubility 
1.07mg/l
form 
Flakes, Powder, Chunks or Crystalline Mass
color 
White
Water Solubility 
<0.1 g/100 mL at 18 ºC
Merck 
14,6333
BRN 
508624
Stability:
Stable. Incompatible with strong oxidizing agents, bases.
CAS DataBase Reference
544-63-8(CAS DataBase Reference)
NIST Chemistry Reference
Tetradecanoic acid(544-63-8)
EPA Substance Registry System
Tetradecanoic acid(544-63-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38-38
Safety Statements  24/25
WGK Germany  -
RTECS  QH4375000
TSCA  Yes
HS Code  29159080
Hazardous Substances Data 544-63-8(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 432.6 mg/kg (Or, Wretlind)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Myristic acid price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 130087 Myristic acid 95% 544-63-8 5g $23.7 2018-11-20 Buy
Sigma-Aldrich 1448990 Myristic acid United States Pharmacopeia (USP) Reference Standard 544-63-8 200mg $386 2018-11-13 Buy
TCI Chemical M0476 Myristic Acid >99.0%(T) 544-63-8 25g $16 2018-11-22 Buy
TCI Chemical M0476 Myristic Acid >99.0%(T) 544-63-8 500g $28 2018-11-22 Buy
Alfa Aesar A12067 Tetradecanoic acid, 98% 544-63-8 500g $29.1 2018-11-13 Buy

Myristic acid Chemical Properties,Uses,Production

Chemical properties

It appears as white to yellowish white solid, sometimes appearing as shiny crystalline solid, or white to yellowish white powder. It has a relative density of 0.8739 (80 ℃), melting point of 54.5 ℃ and the boiling point of 326.2 ℃. Its refractive index (nD60) is 1.4310. It is not soluble in water but soluble in ethanol, ether and chloroform.
Myristin contains about 70% to 80% while other kinds of coconut oil, palm kernel oil also contain it.

Application

Preparation

To prepare the myristic acid, the methyl ester of the mixed fatty acids or mixed fatty acid methyl ester obtained from the coconut oil or palm kernel oil is subject to vacuum fractionation, obtaining myristic acid. For laboratory preparation, glycerol tris (tetradecanoate) is subject to saponification with 10% sodium hydroxide solution, further being acidified with hydrochloric acid to obtain the free myristic acid. It can also be made from tetradecanol.

Toxicity

Natural fatty acids, non-toxic
Can be safely used for food (FDA, § 172.860; 2000).
LD50:43 mg/kg (mouse, transdermal).

Use limit

FEMA (mg/kg): soft drinks 5.3, cold drinks 2.6~10, candy 4.1, baked goods 5.3, pudding class 0.10.

Chemical Properties

white solid

Uses

Myristic Acid is a common saturated fatty acid found in nutmeg, palm kernel oil, coconut oil and butter fat.

Uses

myristic acid is a surfactant and cleansing agent. When combined with potassium, myristic acid soap provides very good, abundant lather. This is a solid organic acid naturally occurring in butter acids such as nutmeg, oil of lovage, coconut oil, mace oil, and most animal and vegetable fats. Although some sources cite it as having no irritation potential, they do indicate comedogenicity potential.

Definition

ChEBI: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.

Uses

Myristic acid is a 14-carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-terminus of proteins in a co-translational process termed N-myristoylation. In addition, there are examples where N-myristoylation occurs post-translationally, when a hidden myristoylation pattern is exposed.

General Description

Oily white crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Myristic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Myristic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Fire Hazard

Myristic acid is probably combustible.

Safety Profile

Poison by intravenous route. Mutation data reported. An eye and human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Purify the acid via the methyl ester (b 153-154o/10mm, n25 1.4350), as for capric acid. [Trachtman & Miller J Am Chem Soc 84 4828 1962.] Also purify it by zone melting. It crystallises from pet ether, and is dried in a vacuum desiccator containing shredded wax. [Beilstein 2 IV 1126.]

Myristic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Myristic acid Suppliers

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Myristic acid Spectrum


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