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Sulfamethoxypyridazine

Sulfamethoxypyridazine
Sulfamethoxypyridazine structure
CAS No.
80-35-3
Chemical Name:
Sulfamethoxypyridazine
Synonyms
SMPZ;Durox;Kinex;Kynex;Vinces;Kineks;Lentac;Longin;Myasul;rp7522
CBNumber:
CB1107025
Molecular Formula:
C11H12N4O3S
Formula Weight:
280.3
MOL File:
80-35-3.mol

Sulfamethoxypyridazine Properties

Melting point:
182-183°
Boiling point:
564.9±60.0 °C(Predicted)
Density 
1.3936 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
2-8°C
form 
Crystalline Powder
pka
6.7(at 25℃)
color 
White to yellow
Water Solubility 
579.5mg/L(25 ºC)
Merck 
14,8919
BRN 
277076
CAS DataBase Reference
80-35-3(CAS DataBase Reference)
FDA UNII
T034E4NS2Z
ATC code
J01ED05
NIST Chemistry Reference
Pyridazine, sulfamethoxy-(80-35-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P280-P305+P351+P338+P310-P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  37/38-41
Safety Statements  26-39
WGK Germany  2
RTECS  WP0400000
10
HS Code  29350090
Toxicity LD50 orally in mice: 1750 mg/kg, (Seki)

Sulfamethoxypyridazine price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46858 Sulfamethoxypyridazine VETRANAL?, analytical standard 80-35-3 250 mg $55.9 2021-12-16 Buy
Sigma-Aldrich S7257 Sulfamethoxypyridazine analytical standard 80-35-3 5g $70.8 2021-12-16 Buy
Sigma-Aldrich S7257 Sulfamethoxypyridazine analytical standard 80-35-3 25g $113 2021-12-16 Buy
Sigma-Aldrich S2150000 Sulfamethoxypyridazine European Pharmacopoeia (EP) Reference Standard 80-35-3 $190 2021-12-16 Buy
Sigma-Aldrich 32981 Sulfamethoxypyridazine-d3 analytical standard 80-35-3 10 mg $255 2021-12-16 Buy

Sulfamethoxypyridazine Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

Antibacterial.

Uses

Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method.

Indications

This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.

Definition

ChEBI: A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position.

brand name

Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44.

World Health Organization (WHO)

Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial.

General Description

Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis.

Pharmaceutical Applications

3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim.

Chemical Synthesis

Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.

Sulfamethoxypyridazine Preparation Products And Raw materials

Raw materials

Preparation Products


Sulfamethoxypyridazine Suppliers

Global( 236)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15418 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
alice@crovellbio.com China 5941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2514 58

View Lastest Price from Sulfamethoxypyridazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Sulfamethoxypyridazine USP/EP/BP
80-35-3
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2021-07-09 Sulfamethoxypyridazine
80-35-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 3,6-Dichloropyridazine
80-35-3
1KG 98% 500 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.

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