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Alatrofloxacin

Alatrofloxacin Structure
Alatrofloxacin structure
CAS No.
146961-76-4
Chemical Name:
Alatrofloxacin
Synonyms
D07562;Alatrofloxacin (inn);UUZPPAMZDFLUHD-VUJLHGSVSA-N;L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-;L-Alanyl-N-[(1alpha,5alpha,6alpha)-3-[6-Carboxy-8-(2,4-Difluorophenyl)-3-Fluoro-5,8-Dihydro-5-Oxo-1,8-Naphthyridin-2-Yl]-3-Azabicyclo[3.1.0]Hex-6-Yl]-L-Alaninamide
CBNumber:
CB11102904
Molecular Formula:
C26H25F3N6O5
Molecular Weight:
558.51
MDL Number:
MFCD02183849
MOL File:
146961-76-4.mol
Last updated:2023-05-04 17:34:33
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Alatrofloxacin Properties

Boiling point 863.2±65.0 °C(Predicted)
Density 1.57±0.1 g/cm3(Predicted)
pka 5.80±0.70(Predicted)
FDA UNII 7QVV6I50DT

Alatrofloxacin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0015025 7-[(1R,5S)-6-([(2S)-1-([(2S)-2-AMINOPROPANOYL]AMINO)-1-OXOPROPAN-2-YL]AMINO)-3-AZABICYCLO[3.1.0]HEXAN-3-YL]-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC?ACID 95.00% 146961-76-4 5MG $502.43 2021-12-16 Buy
Product number Packaging Price Buy
API0015025 5MG $502.43 Buy

Alatrofloxacin Chemical Properties,Uses,Production

Definition

ChEBI: Alatrofloxacin is a peptide.

Enzyme inhibitor

This fourth-generation fluoroquinolone-class antibiotic (FW = 558.51 g/mol; CAS 146961-76-4; quickly hydrolyzes to form trovafloxacin), also named 7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}-1-oxopropan- 2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, is a systemic antibacterial that targets Type II DNA topoisomerases (gyrases) required for bacterial replication and transcription. This fluoroquinolone shows an extensive in vitro antibiotic spectrum, with high activity against Grampositive coccus, anaerobic and atypical pneumonia-producing bacteria. (For the prototypical member of this antibiotic class, See Ciprofloxacin) Intravenous alatrofloxacin, followed by oral trovafloxacin (TVX), is safe and well tolerated. Alatrofloxacin also lacks the phototoxicity, cardiovascular toxicity, and hemolytic anemia associated with earlier fluoroquinolones. Given its metabolism to trovafloxacin, it should be noted that the latter significantly increases the formation of nitrotyrosine in mice that are heterozygous for mitochondrial superoxide dismutase-2. Using the NO-selective probe DAF-2, TVX also increases the production of mitochondrial NO in immortalized human hepatocytes. Similarly, mitochondrial Ca2+ is increased by TVX, suggesting calcium ion-dependent activation of mitochondrial NOS activity. The relationship between these observations and trovafloxacin-induced leukopenia remains to be explored.

Alatrofloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

Alatrofloxacin Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd 		18192627656 1012@dideu.com China 3758 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29627 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9587 58
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9588 58
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921 sales@pharmacodia.com China 2317 55
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Supplier Advantage
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Finetech Industry Limited 		58
Finetech Industry Limited 58
Pharmacodia (Beijing) Co.,Ltd 55
TargetMol Chemicals Inc. 58

View Lastest Price from Alatrofloxacin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Alatrofloxacin USP/EP/BP pictures 2021-07-22 Alatrofloxacin USP/EP/BP
146961-76-4
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Alatrofloxacin pictures 2020-05-21 Alatrofloxacin
146961-76-4
 US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd
Alatrofloxacin pictures 2019-12-23 Alatrofloxacin
146961-76-4
 US $1.00 / KG 1KG 98% HPLC 10t Career Henan Chemical Co
  • Alatrofloxacin pictures
  • Alatrofloxacin
    146961-76-4
  • US $0.01-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
  • Alatrofloxacin pictures
  • Alatrofloxacin
    146961-76-4
  • US $1.00 / KG
  • 98% HPLC
  • Career Henan Chemical Co

146961-76-4(Alatrofloxacin)Related Search:

6-PIPERIDIN-1-YLNICOTINALDEHYDE 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE TROVAFLOXACIN 3-azabicyclo[3.1.0]hexane 3-Fluoro-5-methylpyridine
Alatrofloxacin Ethanone,1-(5-fluoro-3-pyridinyl)- 3-FLUORO-5-FORMYLPYRIDINE 2-Amino-5-fluoropyridine 2-AMINO-N-CYCLOPROPYL-ACETAMIDE
6-(1-PYRROLIDINYL)NICOTINALDEHYDE 2-Amino-3-fluoropyridine 2-Amino-3-acetylpyridine 2,6-Diamino-3-fluoropyridine

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Alatrofloxacin (inn) D07562 UUZPPAMZDFLUHD-VUJLHGSVSA-N L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]- L-Alanyl-N-[(1alpha,5alpha,6alpha)-3-[6-Carboxy-8-(2,4-Difluorophenyl)-3-Fluoro-5,8-Dihydro-5-Oxo-1,8-Naphthyridin-2-Yl]-3-Azabicyclo[3.1.0]Hex-6-Yl]-L-Alaninamide 146961-76-4 C26H25F3N6O5