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DL-Menthol

DL-Menthol
DL-Menthol structure
CAS No.
1490-04-6
Chemical Name:
DL-Menthol
Synonyms
MENTHOL;1-menthol;FEMA 2665;menthanol;ai3-08161;DL-Menthol;MENTHOL, DL-;MEMANTINEHCL;(+/-)-MENTHOL;3-p-Menthanol
CBNumber:
CB1116410
Molecular Formula:
C10H20O
Formula Weight:
156.27
MOL File:
1490-04-6.mol

DL-Menthol Properties

Melting point:
34-36 °C(lit.)
Boiling point:
216 °C(lit.)
Density 
0.89 g/mL at 25 °C(lit.)
vapor pressure 
0.8 mm Hg ( 20 °C)
FEMA 
2665 | MENTHOL RACEMIC
Flash point:
200 °F
solubility 
Very soluble in ethanol (95%), chloroform, ether, fatty oils and liquid paraffin; freely soluble in glacial acetic acid;soluble in acetone and benzene; very slightly soluble in glycerin; practically insoluble in water.
form 
neat
JECFA Number
427
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
NOOLISFMXDJSKH-UHFFFAOYSA-N
CAS DataBase Reference
1490-04-6(CAS DataBase Reference)
NIST Chemistry Reference
Menthol(1490-04-6)
EPA Substance Registry System
Cyclohexanol, 5-methyl-2-(1-methylethyl)- (1490-04-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  37/38-41-48/20/22-40-22
Safety Statements  36/37/39-36-26
RIDADR  UN 1888 6.1/PG 3
WGK Germany  2
RTECS  OT0525000
HS Code  29061100
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

DL-Menthol price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M0350000 Menthol European Pharmacopoeia (EP) Reference Standard 1490-04-6 m0350000 $179 2018-11-23 Buy

DL-Menthol Chemical Properties,Uses,Production

Chemical Properties

colourless crystals

Chemical Properties

Racemic menthol is a mixture of equal parts of the (1R,2S,5R)- and (1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated crystalline powder, or colorless, prismatic, or acicular shiny crystals, or hexagonal or fused masses with a strong characteristic odor and taste. The crystalline form may change with time owing to sublimation within a closed vessel. The USP 32 specifies that menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and PhEur 6.0, along with other pharmacopeias, include two separate monographs for racemic and l-menthol.

Uses

menthol is a fragrance. It is also said to be anti-septic, cooling, refreshing, and a blood-circulation stimulant. Menthol gives the skin a “cool” feeling after use. It constitutes almost 50 percent of peppermint oil but can also be synthetically produced through the hydrogenation of thymol. It is non-toxic in low doses, but in high concentrations it can be irritating to the skin, especially the mucous membranes.

Uses

Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.

Definition

ChEBI: Any secondary alcohol that is one of the eight possible diastereoisomers of 5-methyl-2-(propan-2-yl)cyclohexan-1-ol.

Production Methods

Menthol occurs widely in nature as l-menthol and is the principal component of peppermint and cornmint oils obtained from the Mentha piperita and Mentha arvensis species. Commercially, lmenthol is mainly produced by extraction from these volatile oils. It may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of routes, e.g. by hydrogenation of thymol.

Definition

A white crystalline terpenealcohol, C10H19OH; r.d. 0.89;m.p. 42°C; b.p. 103–104°C. It has aminty taste and is found in certainessential oils (e.g. peppermint) andused as a flavouring.

brand name

Fisherman’s Friend Lozenges (Bristol-Myers Products); Therapeutic Mineral Ice (Bristol-Myers Products).

Pharmaceutical Applications

Menthol is widely used in pharmaceuticals, confectionery, and toiletry products as a flavoring agent or odor enhancer. In addition to its characteristic peppermint flavor, l-menthol, which occurs naturally, also exerts a cooling or refreshing sensation that is exploited in many topical preparations. Unlike mannitol, which exerts a similar effect due to a negative heat of solution, l-menthol interacts directly with the body’s coldness receptors. d-Menthol has no cooling effect, while racemic menthol exerts an effect approximately half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in ethanol (95%) and sprayed onto tablet granules and not used as a solid excipient.
Menthol has been investigated as a skin-penetration enhancer and is also used in perfumery, tobacco products, chewing gum and as a therapeutic agent. When applied to the skin, menthol dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect. It relieves itching and is used in creams, lotions, and ointments. When administered orally in small doses menthol has a carminative action.

Safety

Almost all toxicological data for menthol relate to its use as a therapeutic agent rather than as an excipient. Inhalation or ingestion of large quantities can result in serious adverse reactions such as ataxia and CNS depression,hypersensitivity reactions, severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and coma.Although menthol is essentially nonirritant there have been some reports of hypersensitivity following topical application. In a Polish study approximately 1% of individuals were determined as being sensitive to menthol.There have been reports of apnea and instant collapse in infants after the local application of menthol to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to 0.4 mg/kg body-weight.
LD50 (rat, IM): 10.0 g/kg
LD50 (rat, oral): 3.18 g/kg

storage

A formulation containing menthol 1% w/w in aqueous cream has been reported to be stable for up to 18 months when stored at room temperature.
Menthol should be stored in a well-closed container at a temperature not exceeding 25°C, since it sublimes readily.

Incompatibilities

Incompatible with: butylchloral hydrate; camphor; chloral hydrate; chromium trioxide; b-naphthol; phenol; potassium permanganate; pyrogallol; resorcinol; and thymol.

Regulatory Status

Included in the FDA Inactive Ingredients Database (dental preparations, inhalations, oral aerosols, capsules, solutions, suspensions, syrups, and tablets; also topical preparations). Included in nonparenteral medicines licensed in the UK. Accepted for use in foods and confectionery as a flavoring agent of natural origin. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

DL-Menthol Preparation Products And Raw materials

Raw materials

Preparation Products


DL-Menthol Suppliers

Global( 102)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1007 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 317 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 723 58

View Lastest Price from DL-Menthol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-10 DL-Menthol
1490-04-6
US $1.00 / kg 1kg 99.8% 100kg Hebei Jimi Trading Co., Ltd.
2018-08-20 DL-Menthol
1490-04-6
US $1.00 / KG 1KG 40%-99% 1000kg career henan chemical co

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