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Lapatinib Ditosylate

Lapatinib Ditosylate Structure
Lapatinib Ditosylate structure
CAS No.
388082-77-7
Chemical Name:
Lapatinib Ditosylate
Synonyms
GW-572016F;Tykerb Ditosylat;apatinib DitosyL;Tykerb Ditosylate;Tykerb(lapatinib);Lapatinib Tosylate;Lapatinib ditosylate;GW-572016 ditosylate;GW 572016 ditosylate;Lapatinib ditasylate
CBNumber:
CB11176387
Molecular Formula:
C36H34ClFN4O7S2
Molecular Weight:
753.26
MDL Number:
MFCD09264195
MOL File:
388082-77-7.mol
MSDS File:
SDS
Last updated:2023-09-07 14:58:50
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Lapatinib Ditosylate Properties

Melting point 240-2420C
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility ≥24.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
Water Solubility Water: Insoluble
CAS DataBase Reference 388082-77-7
FDA UNII 4WK72K94MC

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS02
Signal word  Danger
Hazard statements  H315-H319-H225
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Safety Statements  24/25
HS Code  29420000

Lapatinib Ditosylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC L175800 LapatinibDitosylate 388082-77-7 25mg $65 2021-12-16 Buy
TRC L175800 LapatinibDitosylate 388082-77-7 100mg $120 2021-12-16 Buy
TRC L175800 LapatinibDitosylate 388082-77-7 1g $495 2021-12-16 Buy
ChemScene CS-0831 Lapatinibditosylate 99.95% 388082-77-7 5g $540 2021-12-16 Buy
ChemScene CS-0831 Lapatinibditosylate 99.95% 388082-77-7 50mg $60 2021-12-16 Buy
Product number Packaging Price Buy
L175800 25mg $65 Buy
L175800 100mg $120 Buy
L175800 1g $495 Buy
CS-0831 5g $540 Buy
CS-0831 50mg $60 Buy

Lapatinib Ditosylate Chemical Properties,Uses,Production

Description

Lapatinib, an ErB-1 and ErB-2 dual kinase inhibitor, was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline and is also currently being evaluated for several additional cancer indications.

Chemical Properties

Yellow Solid

Uses

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Uses

Lapatinib Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.

Synthesis

The synthesis started with Williamson ether synthesis between 2-chloro-4-nitrophenol (58) and 3-fluorobenzyl bromide to give ether 59 in the following scheme; however, no specific yields were provided. Reduction of the nitro group of compound 59 by catalytic hydrogenation over Pt/C and subsequent condensation of the resulting aniline with 4-chloro-6-iodoquinazoline (61) in refluxing i-PrOH afforded compound 62. 4-Chloro-6-iodoquinazoline (61) was prepared by reacting 6-iodoquinazolin- 4(3H)-one (60) with POCl3 in the presence of triethylamine. Compound 62 was subjected to Stille coupling with 5- dioxolanyl-2-(tributylstannyl)furan (63) in the presence of PdCl2(PPh3)2 to give 64. Acidic hydrolysis of acetal 64 using HCl in THF/H2O provided the corresponding aldehyde which was further subjected to reductive amination with 2-(methan-esulfonyl)ethylamine in the presence of sodium triacetoxyborohydride to yield lapatinib. Lapatinib was treated with ptoluenesulfonic acid solution to give lapatinib ditosylate (IX).

Synthesis_388082-77-7

Lapatinib Ditosylate Preparation Products And Raw materials

Raw materials

Preparation Products

Lapatinib Ditosylate Suppliers

Global( 221)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd
0531-88110457; +8615562555968 info@pharmachemm.com China 246 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12452 58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. 		+86-0531-69954981 +8615666777973 dwyane.wang@boyuanpharm.com China 211 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8822 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Supplier Advantage
Jinan Jianfeng Chemical Co., Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. 		58
career henan chemical co 		58
TianYuan Pharmaceutical CO.,LTD 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from Lapatinib Ditosylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lapatinib ditosylate pictures 2023-09-07 Lapatinib ditosylate
388082-77-7
 US $0.00-0.00 / kg 1kg 99.9% HPLC 10000 SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
Lapatinib Ditosylate pictures 2023-06-20 Lapatinib Ditosylate
388082-77-7
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Lapatinib Ditosylate pictures 2021-07-10 Lapatinib Ditosylate
388082-77-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Lapatinib ditosylate pictures
  • Lapatinib ditosylate
    388082-77-7
  • US $0.00-0.00 / kg
  • 99.9% HPLC
  • SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
  • Lapatinib Ditosylate pictures
  • Lapatinib Ditosylate
    388082-77-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Lapatinib Ditosylate Spectrum

Lapatinib Ditosylate(388082-77-7)1HNMR

388082-77-7(Lapatinib Ditosylate)Related Search:

Lapatinib impurity L Lapatinib 2-Fluoro Impurity Lapatinib 4-Fluoro Impurity N-De[2-(Methylsulfonyl)ethyl] Lapatinib Lapatinib iMpurity
Lapatinib Impurity 16 Lapatinib IMpurity 10 Lapatinib Sorafenib tosylate Gefitinib
Erlotinib hydrochloride Crizotinib Ruxolitinib Olaparib 3-Chloro-4-(3-fluorobenzyloxy)aniline
Lapatinib Lapatinib Ditosylate 2-AMINOETHANETHIOL P-TOLUENESULFONATE

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Lapatinib ditosylate 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, 4-Methylbenzenesulfonate (1:2) Lapatinib Ditosylate (Tykerb) GW 572016 ditosylate GW-572016 ditosylate GW-572016F Tykerb Ditosylat GW-572016F Ditosylate N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate Tykerb Ditosylate N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2) Lapatinib ditasylate N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine bis(4-Methylbenzenesulfonate) Lapatinib (GW-572016) Ditosylate N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate Tykerb(lapatinib) N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate) TYKERB DITOSYLATE; GW 572016 DITOSYLATE; GW-572016 DITOSYLATE GW 572016 DITOSYLATE;GW-572016 DITOSYLATE apatinib DitosyL Lapatinib Tosylate Lapatinib Ditosylate USP/EP/BP Lapatinib ditosylate anhydrous Lapatinib Ditosylate (GW-572016, Tykerb) dipyrido[3,2-a:2',7'-c]phenazine N-3-Chloro-4-(3-fluorophenyl)methoxyphenyl-6-5-2-(methylsulfonyl)ethylaminomethyl-furan-2-yl-4-amino-quinazoline tosylate (1:2) 388082-77-7 C43H42ClFN4O10S3 Inhibitors Final material Intermediates & Fine Chemicals Pharmaceuticals Tyrosine Kinase Inhibitors