GRANZYME B
- CAS No.
- 143180-74-9
- Chemical Name:
- GRANZYME B
- Synonyms
- GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;Recombinant Mouse Gzmb Protein, His Tag;SensiZyme Granzyme B Activity Assay Kit
- CBNumber:
- CB1120279
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01323415
- MOL File:
- Mol file
| storage temp. | -70°C |
|---|---|
| form | buffered aqueous solution |
| FDA UNII | 2OIM6T84W1 |
GRANZYME B price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 356173 | GzmB | 143180-74-9 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 356174 | Gzmb | 143180-74-9 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | G8957-15E | Granzyme B | 143180-74-9 | 100ug | $645 | 2021-12-16 | Buy |
| Usbiological | G8957-15B-Biotin | Granzyme B | 143180-74-9 | 100ul | $666 | 2021-12-16 | Buy |
| Usbiological | G8957-15B-AP | Granzyme B | 143180-74-9 | 100ul | $666 | 2021-12-16 | Buy |
GRANZYME B Chemical Properties,Uses,Production
General Description
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.
Biochem/physiol Actions
Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.
GRANZYME B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 15926423062 | 422450190@qq.com | China | 10132 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| AntibodySystem | 027-65279366 18162686757 | biolab-reagents@atagenix.com | China | 9790 | 58 |
| Supplier | Advantage |
|---|---|
| Creative Enzymes | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| AntibodySystem | 58 |
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