ChemicalBook >> CAS DataBase List >>1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
![1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Structure](CAS/GIF/5627-05-4.gif)
- CAS No.
- 5627-05-4
- Chemical Name:
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
- Synonyms
- dihydrouridine;6-Dihydrouridine;Uridine, 5,6-dihydro-;Uridine Impurity 28（5,6-Dihydrouridine）;5,6-Dihydrouridine RNA-modified nucleoside D;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
- CBNumber:
- CB11235574
- Molecular Formula:
- C9H14N2O6
- Molecular Weight:
- 246.22
- MDL Number:
- MFCD00047490
- MOL File:
- 5627-05-4.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:02
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Properties
| Density | 1.614±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml |
| form | A crystalline solid |
| pka | 12.40±0.20(Predicted) |
| Stability | Hygroscopic |
| FDA UNII | 0D5FR359JO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D449668 | 5,6-Dihydrouridine | 5627-05-4 | 100mg | $800 | 2021-12-16 | Buy |
| TRC | D449668 | 5,6-Dihydrouridine | 5627-05-4 | 250mg | $1755 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H12-1-03 | 5,6-Dihydrouridine 95% | 5627-05-4 | 250mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-0059431 | 5,6-Dihydrouridine 99.87% | 5627-05-4 | 5mg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | NUC0001384 | 5,6-DIHYDRO-URIDINE 95.00% | 5627-05-4 | 5MG | $501.22 | 2021-12-16 | Buy |
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties,Uses,Production
Uses
5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
Definition
ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring.
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Suppliers
Global( 36)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 | haifeng.zhang@pannacean.com | China | 387 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18739 | 57 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
Uridine, 5,6-dihydro-
Uridine Impurity 28（5,6-Dihydrouridine）
6-Dihydrouridine
5,6-Dihydrouridine RNA-modified nucleoside D
dihydrouridine
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
5627-05-4