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Irinotecan

Irinotecan Structure
Irinotecan structure
CAS No.
97682-44-5
Chemical Name:
Irinotecan
Synonyms
CPT-11;IRINOTECAN HCL;CAMPTOSAR;Irinotecan(TECANS);Irinotecan (free Base);[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID;(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate;DQ-2805;SN-38-11;IRINOTECAN
CBNumber:
CB1124156
Molecular Formula:
C33H38N4O6
Molecular Weight:
586.68
MDL Number:
MFCD01862255
MOL File:
97682-44-5.mol
MSDS File:
SDS
Last updated:2023-09-07 18:57:57
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Irinotecan Properties

Melting point 222-223°
Boiling point 873.4±65.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
pka 11.20±0.20(Predicted)
form Solid
color White to Brown
CAS DataBase Reference 97682-44-5(CAS DataBase Reference)
FDA UNII 7673326042
NCI Dictionary of Cancer Terms Camptosar; CPT 11
NCI Drug Dictionary Camptosar
ATC code L01CE02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08,GHS05
Signal word  Danger
Hazard statements  H315-H361-H302-H318-H373
Precautionary statements  P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310
Hazard Codes  Xn
Risk Statements  22
RTECS  DW1061000

Irinotecan price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 2688 CPT11 ≥99%(HPLC) 97682-44-5 10 $229 2021-12-16 Buy
Tocris 2688 CPT11 ≥99%(HPLC) 97682-44-5 50 $960 2021-12-16 Buy
Usbiological 255047 CPT 11 97682-44-5 10mg $480 2021-12-16 Buy
TRC I767523 (+)-Irinotecan 97682-44-5 50mg $60 2021-12-16 Buy
Biosynth Carbosynth FI33814 Irinotecan 97682-44-5 100mg $60 2021-12-16 Buy
Product number Packaging Price Buy
2688 10 $229 Buy
2688 50 $960 Buy
255047 10mg $480 Buy
I767523 50mg $60 Buy
FI33814 100mg $60 Buy

Irinotecan Chemical Properties,Uses,Production

Uses

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively

Uses

(+)-Irinotecan is a Topo I inhibitor.

Definition

ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

brand name

Camptosar (Pharmacia &Upjohn) .

Biological Activity

irinotecan (cpt-11), a prodrug for treating metastatic colorectal cancer, is a topoisomerase i inhibitor for lovo cells and ht-29 cells with ic50 of 15.8 μm and 5.17 μm, respectively [1].in vivo, irinotecan is converted to sn-38, its most active metabolite, by carboxylesterase converting enzyme (cce) [2].

in vitro

irinotecan induced similar amounts of cleavable complexes in lovocells and ht-29 cell lines with the ic50 of 15.8 μm and 5.17 μm, respectively [1].after addition of 157 mm irinotecan to plasma, sn-38 concentration showed linear increase during the first 60-min period, followed by a plateau.in the first 60 min, mean and standard deviation of the conversion rate were 515.9 ± 50.1 pmol/ml/h (n = 69), with a coefficient of variation of 0.097 [2]. irinotecan (cpt-11) was significantly more active in sclc than in nsclccelllines (p = 0.0036). ce activity appeared to be associated with higher sensitivity to cpt-11 in human lung cancercelllines and may partly explain the difference in the in vitro sensitivity to cpt-11 between sclc and nsclccells [3].in vitro, the sensitivity to cpt-11 and sn-38 was highest in ls174t and colo 320cells, intermediate in sw1398cellsand lowest in colo 205 and widr cells. the activity of sn-38 was 130 to 570 times than cpt-11[4].

in vivo

in colo 320 xenografts, irinotecan induced a maximum growth inhibition of 92% [4].a single dose of irinotecan significantly increased amounts of topoisomerase i covalently bound to dna in stomach, duodenum, colon and liver. concomitantly, the irinotecan-treated group exihibited significantly higher amounts of dna strand breaks in colon mucosa cells compared to the control group [5].

References

[1]. tobin p, clarke s, seale j p, et al. the in vitro metabolism of irinotecan (cpt‐11) by carboxylesterase and β‐glucuronidase in human colorectal tumours[j]. british journal of clinical pharmacology, 2006, 62(1): 122-129.
[2]. shingyoji m, takiguchi y, watanabe‐uruma r, et al. in vitro conversion of irinotecan to sn‐38 in human plasma[j]. cancer science, 2004, 95(6): 537-540.
[3]. van ark-otte j, kedde m a, van der vijgh w j, et al. determinants of cpt-11 and sn-38 activities in human lung cancer cells[j]. british journal of cancer, 1998, 77(12): 2171.
[4]. jansen w j m, zwart b, hulscher s t m, et al. cpt-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants[j]. international journal of cancer, 1997, 70(3): 335-340.
[5]. na y s, jung k a, kim s m, et al. the histone deacetylase inhibitor pxd101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models[j]. cancer chemotherapy and pharmacology, 2011, 68(2): 389-398.

Irinotecan Preparation Products And Raw materials

Raw materials

Nitrogen (+)-Camptothecin 7-Ethyl camptothecin 7-Ethyl-10-hydroxycamptothecin N-ACETYL-D-GALACTOSAMINE(GALACTOSE-13C6, 99%)

Preparation Products

Irinotecan Suppliers

Global( 403)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9350 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Biochempartner 		58

Related articles

View Lastest Price from Irinotecan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
lrinotecan pictures 2024-04-12 lrinotecan
97682-44-5
 US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Irinotecan pictures 2023-11-01 Irinotecan
97682-44-5
 US $0.00-0.00 / kg 1kg 99.9% 20 tons Hangzhou ICH Biofarm Co., Ltd
Irinotecan pictures 2023-06-15 Irinotecan
97682-44-5
 US $825.00 / g/Bag 10g 99% 1kg Baoji Guokang Bio-Technology Co., Ltd.
  • lrinotecan pictures
  • lrinotecan
    97682-44-5
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • Irinotecan pictures
  • Irinotecan
    97682-44-5
  • US $0.00-0.00 / kg
  • 99.9%
  • Hangzhou ICH Biofarm Co., Ltd
  • Irinotecan pictures
  • Irinotecan
    97682-44-5
  • US $825.00 / g/Bag
  • 99%
  • Baoji Guokang Bio-Technology Co., Ltd.

Irinotecan Spectrum

Irinotecan(97682-44-5)1HNMR

97682-44-5(Irinotecan)Related Search:

Paclitaxel Docetaxel (+)-Camptothecin Diethyl malonate Diethyl carbonate
IRINOTECAN HCL,IRINOTECAN HYDROCHLORIDE Mefenpyr-diethyl Diethyl phthalate sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate 7,11-Diethyl-10-hydroxycaMptothecin
Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan SN-38 GLUCURONIDE 10-Hydroxycamptothecin
7-Ethylcamptothecin 7-Ethyl-10-hydroxycamptothecin Irinotecan IMpurity G

1of4

1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester DQ-2805 (4S)-4,11-Diethyl-4-hydroxy-9-[[(4-piperidinopiperidino)carbonyl]oxy]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione SN-38-11 [1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv. Irinotecan base (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylic acid (s)-[1,4'-bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER Irinotecan Labeled d10 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2- TOPOTECIN HYDROCHLORIDE IRINOTECAN CAMPTOTHECIN 11 HYDROCHLORIDE CAMPTOTHECIN 11 HYDROCHLORIDE,TOPOTECIN Irinotecan(Cpt-11) (1,4'-Bipiperidine)-1'-carboxylicacid(S)-4,11-di] Irinotecane [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester IRINOTECAN HCL(P) [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester (9CI) Irinotecan USP/EP/BP (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate Irinotecan EP Impurity L Irinotecan Monomer Irinotecanum IrinotecanQ: What is Irinotecan Q: What is the CAS Number of Irinotecan Q: What is the storage condition of Irinotecan Q: What are the applications of Irinotecan Irinotecan (free Base) [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID CPT-11 IRINOTECAN HCL CAMPTOSAR Irinotecan(TECANS) (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate Propanamide,N-(3-bromophenyl)-8-chloro- (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate 97682-44-5 97682-44-8 C33H38N4O6 Camptothecin series APIs Natural Anti-cancer Medical Materials and It's Derivatives API's chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract API Anti cancer Inhibitors Camptosar, Campto Anti-cancer&immunity