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Ethyl 4,4,4-trifluoroacetoacetate

Ethyl 4,4,4-trifluoroacetoacetate structure

CAS No.: 372-31-6

Chemical Name:: Ethyl 4,4,4-trifluoroacetoacetate

Synonyms: ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE;ETHYL TRIFLUOROACETOACETATE;ETFAA;4,4,4-trifL;AKOS B020306;uoroacetoacetate;TIMTEC-BB SBB008825;Ethyl 4,4,4-trifluor;4-trifluoroacetoacetate;Ethyl 4,4,4-trifluoroaceto

CBNumber:: CB1133091

Molecular Formula:: C6H7F3O3

Molecular Weight:: 184.11

MDL Number:: MFCD00000424

MOL File:: 372-31-6.mol

MSDS File:: SDS

Last updated:2024-01-10 10:42:46

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Ethyl 4,4,4-trifluoroacetoacetate Properties

Melting point	-39 °C
Boiling point	129-130 °C(lit.)
Density	1.259 g/mL at 25 °C(lit.)
vapor pressure	8hPa at 20℃
refractive index	n20/D 1.375(lit.)
Flash point	84 °F
storage temp.	Sealed in dry,Room Temperature
solubility	10g/l
form	Liquid
pka	7.76±0.10(Predicted)
color	Clear colorless to slightly yellow
Specific Gravity	1.259 (20/4℃)
PH	6.2 (10g/l, H2O, 20℃)
Water Solubility	10 g/L (20 ºC)
BRN	608353
InChIKey	OCJKUQIPRNZDTK-UHFFFAOYSA-N
CAS DataBase Reference	372-31-6(CAS DataBase Reference)
FDA UNII	KM9XB46R5T
NIST Chemistry Reference	Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry System	Ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H302-H412

Precautionary statements

P210-P273-P301+P312+P330

Hazard Codes

Xn,F,C,Xi

Risk Statements

10-22-52/53

Safety Statements

61-16

RIDADR

UN 3272 3/PG 3

WGK Germany

Hazard Note

Flammable/Corrosive

TSCA

HazardClass

PackingGroup

III

HS Code

29183000

NFPA 704

	3
2		0

Ethyl 4,4,4-trifluoroacetoacetate price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T0810	Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	372-31-6	25g	$75	2024-03-01	Buy
TCI Chemical	T0810	Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	372-31-6	100g	$195	2024-03-01	Buy
Alfa Aesar	A13717	Ethyl trifluoroacetoacetate, 98+%	372-31-6	10g	$39.65	2024-03-01	Buy
Alfa Aesar	A13717	Ethyl trifluoroacetoacetate, 98+%	372-31-6	50g	$128.65	2024-03-01	Buy
Sigma-Aldrich	E50205	Ethyl 4,4,4-trifluoroacetoacetate 99%	372-31-6	5g	$32.8	2024-03-01	Buy

Product number	Packaging	Price	Buy
T0810	25g	$75	Buy
T0810	100g	$195	Buy
A13717	10g	$39.65	Buy
A13717	50g	$128.65	Buy
E50205	5g	$32.8	Buy

Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties,Uses,Production

Chemical Properties

Clear liquid

Uses

Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Flammability and Explosibility

Flammable

Synthesis

With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized.

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL

1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE THIFLUZAMIDE Ethyl 3-amino-4,4,4-trifluorocrotonate 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE

ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 4-Methylpyrimidine 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97%

Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% Coumarin 151 ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline

6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97% 4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE

(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-bromo-2-(trifluoromethyl)quinoline 4-(Trifluoromethyl)quinolin-2-amine 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone

4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE 2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

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Ethyl 4,4,4-trifluoroacetoacetate Suppliers

Global( 551)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Nanjing Sinoda Biological Technology Co., Ltd	+8613401983379	sales@njmcn.cn	CHINA	74	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
LEAPCHEM CO., LTD.	58
Nanjing Sinoda Biological Technology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58

View Lastest Price from Ethyl 4,4,4-trifluoroacetoacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-26	Ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-04-12	Ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $15.00 / Kg/Bag	1Kg/Bag	99.7%	Weekly supply of 1000KG	Wuhan Dujiang Industrial Co., Ltd.
2023-03-06	Ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $9.10 / KG	1KG	99.%	10000	Hebei Guanlang Biotechnology Co,.LTD

Ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $15.00 / Kg/Bag
99.7%
Wuhan Dujiang Industrial Co., Ltd.

Ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $9.10 / KG
99.%
Hebei Guanlang Biotechnology Co,.LTD

Ethyl 4,4,4-trifluoroacetoacetate Spectrum

Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)MS Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)¹HNMR Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)¹³CNMR Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)IR1 Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)Raman

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Ethyl 4,4,4-trifluoro-3-oxobutyrate (Trifluoroacetyl)acetic acid ethyl ester 2-(Trifluoroacetyl)acetic acid ethyl ester 3-Oxo-4,4,4-trifluorobutanoic acid ethyl ester 4,4,4-Trifluoro-3-oxobutyric acid ethyl ester Trifluoroacetylacetic acid ethyl ester Ethyl 4,4,4-trifluoroacetoacetate 98% Ethyl4,4,4-trifluoroacetoacetate98% Ethyl 4,4,4-trifluoroacetoacetate,Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate, 97%+ Ethyl 4,4,4-trifluoro-3-oxobutanoate, 95%+ ETHYL TRIFLUOROACETOACETATE 98% Ethyl 4,4,4-trifluoroacetoacetate,97% Ethyl 2-(trifluoroacethyl)acetate ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE ETHYL 3-OXO,4,4,4-TRIFLUOROBUTYRATE ETHYL 4,4,4-TRIFLUOROACETOACETATE ETHYL 4,4,4-TRIFLUOROACETOACTATE TIMTEC-BB SBB008825 4,4,4-TRIFLUORO-3-OXOBUTANOIC ACID ETHYL ESTER 4,4,4-TRIFLUOROACETOACETIC ACID ETHYL ESTER AKOS B020306 4,4,4-trifluoro-3-oxo-butanoicaciethylester Acetoacetic acid, 4,4,4-trifluoro-, ethyl ester Acetoacetic acid, 4-trifluoro-, ethyl ester Butanoicacid,4,4,4-trifluoro-3-oxo-,ethylester Ethyl (trifluoroacetyl)acetate Ethyl gamma,gamma,gamma-trifluoroacetoacetate Ethyl omega,omega,omega-trifluoroacetoacetate Ethyl 4,4,4-trifluor TRIFLUOROACETOACETIC ACID ETHYL ESTER Ethyl 4,4,4-trifluoroacetocaetate Ethyl 4,4,4-trifluoroaceto 4,4,4- threefluorideethyl acetoacetate Trifluoro ethyl acetoacetate 4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (Ethyl trifluoroacetoacetate) Ethyl 4,4,4-trifluoro-3-oxobutanoate, Ethyl 4,4,4-trifluoro-3-oxobutyrate Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate 4,4,4-Trifluoroacetoacetic Acid Ethyl Ester Ethyl4,4,-Trifluoroacetoacetate Ethyltrifluoroacetoacetate,98+% ETHYL 4,4,4-TRIFLUOROACETYLACETATE 1-Ethoxy-4,4,4-trifluorobutane-1,3-dione Ethyl 3-oxo-4,4,4-trifluorobutanoate 1-Ethoxy-4,4,4-trifluorobutane 4-trifluoroacetoacetate Ethyl4,4,4-trifluoroacetoacetate (ETFAA) 4,4,4-trifL uoroacetoacetate Ethyl 4,4,4-trifluoroacetoa ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE ETHYL TRIFLUOROACETOACETATE ETFAA Ethyl-4,4,4-trifluoracetoacetat 4,4,4-Ethyl trifluoroacetyl acetate Ethyl 4,4,4-trifluoroacetoacetate?New 372-31-6 373-31-6 371-31-6