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Ethyl 4,4,4-trifluoroacetoacetate

Ethyl 4,4,4-trifluoroacetoacetate structure

CAS No.: 372-31-6

Chemical Name:: Ethyl 4,4,4-trifluoroacetoacetate

Synonyms: ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE;ETHYL TRIFLUOROACETOACETATE;ETFAA;4,4,4-trifL;AKOS B020306;uoroacetoacetate;TIMTEC-BB SBB008825;Ethyl 4,4,4-trifluor;Trifluoroacylacidester;4-trifluoroacetoacetate

CBNumber:: CB1133091

Molecular Formula:: C6H7F3O3

Molecular Weight:: 184.11

MDL Number:: MFCD00000424

MOL File:: 372-31-6.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:22

Product description	Number	Pack Size	Price
Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	T0810	25g	$75
Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	T0810	100g	$195
Ethyl 4,4,4-trifluoroacetoacetate 99%	E50205	5g	$33.8
Ethyl 4,4,4-trifluoroacetoacetate 99%	E50205	25g	$55.4
Ethyl 4,4,4-trifluoroacetoacetate 99%	E50205	100g	$116
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Ethyl 4,4,4-trifluoroacetoacetate Properties

Melting point	-39 °C
Boiling point	129-130 °C(lit.)
Density	1.259 g/mL at 25 °C(lit.)
vapor pressure	8hPa at 20℃
refractive index	n20/D 1.375(lit.)
Flash point	84 °F
storage temp.	Sealed in dry,Room Temperature
solubility	10g/l
form	Liquid
pka	7.76±0.10(Predicted)
Specific Gravity	1.259 (20/4℃)
color	Clear colorless to slightly yellow
PH	6.2 (10g/l, H2O, 20℃)
Water Solubility	10 g/L (20 ºC)
BRN	608353
InChI	1S/C6H7F3O3/c1-2-12-5(11)3-4(10)6(7,8)9/h2-3H2,1H3
InChIKey	OCJKUQIPRNZDTK-UHFFFAOYSA-N
SMILES	CCOC(=O)CC(=O)C(F)(F)F
CAS DataBase Reference	372-31-6(CAS DataBase Reference)
FDA UNII	KM9XB46R5T
NIST Chemistry Reference	Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry System	Ethyl 4,4,4-trifluoroacetoacetate (372-31-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H302-H412

Precautionary statements

P210-P273-P301+P312+P330

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,F,C,Xi

Risk Statements

10-22-52/53

Safety Statements

61-16

RIDADR

UN 3272 3/PG 3

WGK Germany

Hazard Note

Flammable/Corrosive

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29183000

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 3
Flam. Liq. 3

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	3
2		0

Ethyl 4,4,4-trifluoroacetoacetate price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T0810	Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	372-31-6	25g	$75	2025-07-31	Buy
TCI Chemical	T0810	Ethyl 4,4,4-Trifluoroacetoacetate >98.0%(GC)	372-31-6	100g	$195	2025-07-31	Buy
Sigma-Aldrich	E50205	Ethyl 4,4,4-trifluoroacetoacetate 99%	372-31-6	5g	$33.8	2025-07-31	Buy
Sigma-Aldrich	E50205	Ethyl 4,4,4-trifluoroacetoacetate 99%	372-31-6	25g	$55.4	2025-07-31	Buy
Sigma-Aldrich	E50205	Ethyl 4,4,4-trifluoroacetoacetate 99%	372-31-6	100g	$116	2025-07-31	Buy

Product number	Packaging	Price	Buy
T0810	25g	$75	Buy
T0810	100g	$195	Buy
E50205	5g	$33.8	Buy
E50205	25g	$55.4	Buy
E50205	100g	$116	Buy

Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties,Uses,Production

Chemical Properties

Clear liquid

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Uses

Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Flammability and Explosibility

Flammable

Synthesis

With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized.

References

[1] Journal of Fluorine Chemistry, 1982, vol. 20, p. 187
[2] Patent: CN103214355, 2016, B. Location in patent: Paragraph 0076
[3] Bulletin des Societes Chimiques Belges, 1926, vol. 35, p. 414
[4] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1926, vol. <5> 12, p. 680,692
[5] Chem. Zentralbl., 1927, vol. 98, # I, p. 996,1286

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid Ethyl trifluoroacetate Ethyl acetate

Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL

1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE THIFLUZAMIDE Ethyl 3-amino-4,4,4-trifluorocrotonate 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE

ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 4-Methylpyrimidine 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97%

Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% Coumarin 151 ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline

6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97% 4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE

(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-bromo-2-(trifluoromethyl)quinoline 4-(Trifluoromethyl)quinolin-2-amine 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone

4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE 2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

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Ethyl 4,4,4-trifluoroacetoacetate Suppliers

Global( 581)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Nanjing Sinoda Biological Technology Co., Ltd	+8613401983379	sales@njmcn.cn	CHINA	74	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8754	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3999	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9307	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13619	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21600	55

Supplier	Advantage
HANGZHOU LEAP CHEM CO., LTD.	58
Nanjing Sinoda Biological Technology Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Aochuang Chemical Co.,Ltd.	58
Chongqing Soarwin Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

Application research of Ethyl 4,4,4-trifluoroacetoacetate
Ethyl 4,4,4-trifluoroacetoacetate is an important intermediate for the synthesis of fluorinated compounds such as pesticides a....
Nov 11，2025

View Lastest Price from Ethyl 4,4,4-trifluoroacetoacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-05	Ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-25	Ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2025-11-19	ethyl 4,4,4-trifluoroacetoacetate 372-31-6	US $0.00 / kg	20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.

Ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

ethyl 4,4,4-trifluoroacetoacetate
372-31-6
US $0.00 / kg
99%
Qingdao RENAS Polymer Material Co., Ltd.

Ethyl 4,4,4-trifluoroacetoacetate Spectrum

Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)MS Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)¹HNMR Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)¹³CNMR Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)IR1 Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)Raman

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Ethyl 4,4,4-trifluoro-3-oxobutyrate (Trifluoroacetyl)acetic acid ethyl ester 2-(Trifluoroacetyl)acetic acid ethyl ester 3-Oxo-4,4,4-trifluorobutanoic acid ethyl ester 4,4,4-Trifluoro-3-oxobutyric acid ethyl ester Trifluoroacetylacetic acid ethyl ester Ethyl 4,4,4-trifluoroacetoacetate 98% Ethyl4,4,4-trifluoroacetoacetate98% Ethyl 4,4,4-trifluoroacetoacetate,Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate, 97%+ Ethyl 4,4,4-trifluoro-3-oxobutanoate, 95%+ ETHYL TRIFLUOROACETOACETATE 98% Ethyl 4,4,4-trifluoroacetoacetate,97% Ethyl 2-(trifluoroacethyl)acetate ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE ETHYL 3-OXO,4,4,4-TRIFLUOROBUTYRATE ETHYL 4,4,4-TRIFLUOROACETOACETATE ETHYL 4,4,4-TRIFLUOROACETOACTATE TIMTEC-BB SBB008825 4,4,4-TRIFLUORO-3-OXOBUTANOIC ACID ETHYL ESTER 4,4,4-TRIFLUOROACETOACETIC ACID ETHYL ESTER AKOS B020306 4,4,4-trifluoro-3-oxo-butanoicaciethylester Acetoacetic acid, 4,4,4-trifluoro-, ethyl ester Acetoacetic acid, 4-trifluoro-, ethyl ester Butanoicacid,4,4,4-trifluoro-3-oxo-,ethylester Ethyl (trifluoroacetyl)acetate Ethyl gamma,gamma,gamma-trifluoroacetoacetate Ethyl omega,omega,omega-trifluoroacetoacetate Ethyl 4,4,4-trifluor TRIFLUOROACETOACETIC ACID ETHYL ESTER Ethyl 4,4,4-trifluoroacetocaetate Ethyl 4,4,4-trifluoroaceto 4,4,4- threefluorideethyl acetoacetate Trifluoro ethyl acetoacetate 4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (Ethyl trifluoroacetoacetate) Ethyl 4,4,4-trifluoro-3-oxobutanoate, Ethyl 4,4,4-trifluoro-3-oxobutyrate Ethyl 3-oxo-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-oxobutanoate 4,4,4-Trifluoroacetoacetic Acid Ethyl Ester Ethyl4,4,-Trifluoroacetoacetate Ethyltrifluoroacetoacetate,98+% ETHYL 4,4,4-TRIFLUOROACETYLACETATE 1-Ethoxy-4,4,4-trifluorobutane-1,3-dione Ethyl 3-oxo-4,4,4-trifluorobutanoate 1-Ethoxy-4,4,4-trifluorobutane 4-trifluoroacetoacetate Ethyl4,4,4-trifluoroacetoacetate (ETFAA) 4,4,4-trifL uoroacetoacetate Ethyl 4,4,4-trifluoroacetoa ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE ETHYL TRIFLUOROACETOACETATE ETFAA Ethyl-4,4,4-trifluoracetoacetat 4,4,4-Ethyl trifluoroacetyl acetate Ethyl 4,4,4-trifluoroacetoacetate?New Ethyl4,4,4-Triflouroacetoacetate Trifluoroacylacidester 372-31-6

Ethyl 4,4,4-trifluoroacetoacetate

Ethyl 4,4,4-trifluoroacetoacetate Properties

SAFETY

Risk and Safety Statements

Ethyl 4,4,4-trifluoroacetoacetate price More Price(37)

Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Flammability and Explosibility

Synthesis

References

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 4,4,4-trifluoroacetoacetate Suppliers

Related articles

View Lastest Price from Ethyl 4,4,4-trifluoroacetoacetate manufacturers

Ethyl 4,4,4-trifluoroacetoacetate Spectrum

372-31-6(Ethyl 4,4,4-trifluoroacetoacetate)Related Search: