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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole structure

CAS No.: 150493-34-8

Chemical Name:: 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

Synonyms: NS 638;NS638, >98%;NS-638;NS 638;2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638

CBNumber:: CB11344812

Molecular Formula:: C15H11ClF3N3

Molecular Weight:: 325.72

MDL Number:

MOL File:: 150493-34-8.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:05

Request For Quotation

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Properties

Boiling point	476.3±55.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form	A solid
pka	5.15±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-6337	NS-638 >98.0%	150493-34-8	2mg	$50	2021-12-16	Buy
ChemScene	CS-6337	NS-638 >98.0%	150493-34-8	5mg	$100	2021-12-16	Buy
ChemScene	CS-6337	NS-638 >98.0%	150493-34-8	10mg	$150	2021-12-16	Buy
ChemScene	CS-6337	NS-638 >98.0%	150493-34-8	25mg	$290	2021-12-16	Buy
ChemScene	CS-6337	NS-638 >98.0%	150493-34-8	50mg	$470	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-6337	2mg	$50	Buy
CS-6337	5mg	$100	Buy
CS-6337	10mg	$150	Buy
CS-6337	25mg	$290	Buy
CS-6337	50mg	$470	Buy

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties,Uses,Production

Biological Activity

NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.

in vivo

In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.

target

IC50: 3.4 μM (K ⁺ -stimulated intracellular Ca ²⁺ -elevation)

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

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1-(4-Chlorophenylmethyl)-2-aminobenzimidazole 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole NS 638 1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)- 1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine NS-638;NS 638 NS638, >98% 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638 Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638 150493-34-8