ChemicalBook >> CAS DataBase List >>8-hydroxyloxapine
8-hydroxyloxapine
- CAS No.
- 61443-77-4
- Chemical Name:
- 8-hydroxyloxapine
- Synonyms
- 8-hydroxyloxapine;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
- CBNumber:
- CB11370570
- Molecular Formula:
- C18H18ClN3O2
- Molecular Weight:
- 343.81
- MDL Number:
- MOL File:
- 61443-77-4.mol
Last updated:2023-06-08 09:03:09
| Melting point | 212-215°C |
|---|---|
| storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble |
| form | A solid |
| Stability | Light Sensitive |
| FDA UNII | 0Q6HMM3XRC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
| NFPA 704 |
|
8-hydroxyloxapine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21786 | 8-hydroxy Loxapine ≥98% | 61443-77-4 | 500μg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 21786 | 8-hydroxy Loxapine ≥98% | 61443-77-4 | 1mg | $290 | 2024-03-01 | Buy |
| TRC | H943730 | 8-HydroxyLoxapine | 61443-77-4 | 1mg | $260 | 2021-12-16 | Buy |
| Usbiological | 013929 | 8-Hydroxy Loxapine | 61443-77-4 | 1mg | $566 | 2021-12-16 | Buy |
| AK Scientific | 3064CA | 8-Hydroxyloxapine | 61443-77-4 | 1mg | $421 | 2021-12-16 | Buy |
8-hydroxyloxapine Chemical Properties,Uses,Production
Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical Properties
Pale Yellow Solid
Uses
The inactive
8-hydroxyloxapine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 13)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55672 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
61443-77-4(8-hydroxyloxapine)Related Search:
8-hydroxyloxapine
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
Loxapine 8-Hydroxy Impurity
61443-77-4
Heterocycles
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals