Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>HBTU

HBTU

HBTU Structure
HBTU structure
CAS No.
94790-37-1
Chemical Name:
HBTU
Synonyms
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide;O-benzotriazol-l-yl-tetramethyluroniumhexafluorophosphate;O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;HBTU;-1-yL;HBTU,99%
CBNumber:
CB1138465
Molecular Formula:
C11H16F6N5OP
Molecular Weight:
379.25
MDL Number:
MFCD00075445
MOL File:
94790-37-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:10
Product description Number Pack Size Price
HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem? 8.51006 25g $79.1
HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem? 8.51006 100g $237
HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® 8.51006 1 kg $556
HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® 8.51006 2.5 kg $1120
HBTU ≥98.0% (T) 12804 1g $57.4
More product size
Request For Quotation

HBTU Properties

Melting point 200 °C (dec.)(lit.)
Flash point 200°C
storage temp. Store at +2°C to +8°C.
solubility acetonitrile: 0.1 g/mL, clear
form Powder
color White to Off-White
PH 4.1 (1.6g/l, H2O)
Water Solubility 1.6g/L
Decomposition 200 ºC
BRN 7328329
Stability Stable. Incompatible with oxidizing agents.
Major Application peptide synthesis
InChI InChI=1S/C11H16N5O.F6P/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChIKey UQYZFNUUOSSNKT-UHFFFAOYSA-N
SMILES [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C
CAS DataBase Reference 94790-37-1(CAS DataBase Reference)
FDA UNII X5I03TZQ8D
EPA Substance Registry System 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1) (94790-37-1)
UNSPSC Code 12352107
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H317-H335
Precautionary statements  P261-P264-P271-P272-P280-P302+P352
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22-42/43
Safety Statements  26-36/37/39-36-22
WGK Germany  3
F  8-10-21
Hazard Note  Irritant
HS Code  29339980
Storage Class 11 - Combustible Solids
Hazard Classifications Skin Sens. 1A
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
NFPA 704
1
2 0

HBTU price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51006 HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem? 94790-37-1 25g $79.1 2026-04-30 Buy
Sigma-Aldrich 8.51006 HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem? 94790-37-1 100g $237 2026-04-30 Buy
Sigma-Aldrich 8.51006 HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® 94790-37-1 1 kg $556 2026-04-30 Buy
Sigma-Aldrich 8.51006 HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® 94790-37-1 2.5 kg $1120 2026-04-30 Buy
Sigma-Aldrich 12804 HBTU ≥98.0% (T) 94790-37-1 1g $57.4 2026-04-30 Buy
Product number Packaging Price Buy
8.51006 25g $79.1 Buy
8.51006 100g $237 Buy
8.51006 1 kg $556 Buy
8.51006 2.5 kg $1120 Buy
12804 1g $57.4 Buy

HBTU Chemical Properties,Uses,Production

Chemical Properties

white to light yellow powder

Uses

HBTU is a coupling reagent used in peptide synthesis. HBTU has been shown to effectively suppress racemization.

reaction suitability

reaction type: Coupling Reactions

Biological Activity

hbtu (2-(1h-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexauorophosphate), a coupling reagent commonly used in solid phase peptide synthesis. after being introduced in 1978, this agent shows popularity in chemistry and industry use due to its mild activating properties. moreover, it also shows resistance against racemization. low tendency for racemization is a key requirement for peptide synthesis. especially for solid phase peptide synthesis, quantitative yields with short reaction times are crucial in order to make the synthesis of large peptides feasible. [1]

Synthesis

HBTU is synthesized by reaction of HOBt with TCFH under basic conditions.

in vitro

peptide synthesis relied mostly on efficient and safe coupling reagents. hbtu was proved to transform carboxylic acids into azides efficiently and practically. the process might be applied to a wide range of carboxylic acids including n-protected amino acids. in addition, hbtu was of great value in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids. the advantages of hbtu included the following points: 1) non-explosive and therefore more suitable for solution/solid phase peptide synthesis. 2) high solubility and stability in classical solvents. 3) feasible for colorimetric reaction monitoring. [2]

Purification Methods

Wash the salt with H2O (3x), CH2Cl2 (3x), dry and recrystallise it from MeCN. Dry it in a vacuum and store it cold in the dark [Dourtoglou et al. Tetrahedron Lett 1269 1978, NMR: Dourtoglou and Gross Synthesis 572 1984]. Benzoxazolinone (2 -hydroxybenzoxazole) [59 -49 -4] M 135.1, m 137 -139o, 142 -143o(corrected), b 121-213o/17mm, 335-337o/760mm. Benzoxazolinone is purified by recrystallisation from aqueous Me2CO followed by distillation at atmospheric pressure, then in a vacuum. The methyl mercury salt recrystallises from aqueous EtOH and has m 156-158o. [Bywater et al. J Am Chem Soc 67 905 1945, Beilstein 27 III/IV 2677.]

References

[1]adam s. hbtu: a mild activating ageiw of muramic acid. bioorg med chem lett. 1992 mar; 2(6): 571-4.
[2]knorr r, trzeciak a, bannwarth w and gillessen d. new coupling reagents in peptide chemistry. tetrahedron lett. 1989; 30(15): 1927-30.

HBTU Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, (3,3-difluoro-1-azetidinyl)[8,9-dihydro-9-methoxy-2,3-dimethyl-9-(2-methylphenyl)-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-6-yl]-

HBTU Suppliers

Global( 621)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
Science Care Ningbo Co.,Ltd 		+86-574-87260203 bd@scningbo.hk China 299 58
Jiangsu Vcan Advanced Material Co., Ltd.
+86-17306299870 +86-18652789875 vcanam@vcanam.com China 49 58
Xinxiang Juyuan Biological Technology Co., Ltd.
+8615637360870 sales@xxkfqchem.com China 19 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13843 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
Science Care Ningbo Co.,Ltd 		58
Jiangsu Vcan Advanced Material Co., Ltd.
58
Xinxiang Juyuan Biological Technology Co., Ltd.
58
Hebei Fengjia New Material Co., Ltd 		58
airuikechemical co., ltd. 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

Related Qustion

Ask a question
Q:What are the benefits of HBTU in peptide synthesis?Anonymous - Aug 18，2025
A:HBTU has the characteristics of high coupling efficiency, mild reaction conditions, low side reactions, and easy to use in combination with other coupling agents to achieve synergistic effects. HBTU coupling reagents are particularly suitable for the synthesis of long peptides. It can shorten the reaction time and improve the yield of peptide bond formation, thereby achieving high reactivity and coupling efficiency. Additionally, HBTU reagents effectively inhibit racemisation, forming stable intermediates and reducing the occurrence of side reactions. HBTU can also be used under mild conditions, avoiding damage to sensitive amino acids or peptide fragments. When used in combination with HOBt, HBTU further enhances coupling reaction efficiency.
Q:What is the HBTU coupling mechanism?Anonymous - Aug 18，2025
A:HBTU is a widely used peptide coupling reagent for both solid-phase and solution reactions and is the preferred reagent for coupling phosphorylated amino acids. Its coupling mechanism is via activation of the carboxyl group (-COOH) to form a reactive intermediate, an activated ester, which is then attacked by an amine to form the desired peptide bond.

View Lastest Price from HBTU manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HBTU pictures 2026-04-11 HBTU
94790-37-1
 US $750.00 / kg 1kg 99 50tons Xinxiang Juyuan Biological Technology Co., Ltd.
HBTU pictures 2026-01-04 HBTU
94790-37-1
 US $0.00-0.00 / kg 0.1kg 99.0%min 2000kg Hangzhou ICH Biofarm Co., Ltd
Hbtu pictures 2025-04-15 Hbtu
94790-37-1
 US $75.00-20.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
  • HBTU pictures
  • HBTU
    94790-37-1
  • US $750.00 / kg
  • 99
  • Xinxiang Juyuan Biological Technology Co., Ltd.
  • HBTU pictures
  • HBTU
    94790-37-1
  • US $0.00-0.00 / kg
  • 99.0%min
  • Hangzhou ICH Biofarm Co., Ltd
  • Hbtu pictures
  • Hbtu
    94790-37-1
  • US $75.00-20.00 / kg
  • 99%
  • Hebei Zhuanglai Chemical Trading Co.,Ltd

HBTU Spectrum

HBTU(94790-37-1)1HNMRHBTU(94790-37-1)FT-IR

94790-37-1(HBTU)Related Search:

2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate HOAt 1-Hydroxybenzotriazole HATU Hexafluorophosphoric acid
Potassium hexafluorophosphate 5-Methyl-1H-benzotriazole Tolyltriazole Lithium hexafluorophosphate Sodium hexafluorophosphate
1H-Benzotriazole 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one TBTU 1-Hydroxybenzotriazole hydrate Ammonium hexafluorophosphate
5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate (Benzotriazol-1-yloxy)dipyrrolidinocarbenium hexafluorophosphate HBTU

1of4

O-(BENZOTRIAZOL-1-YL)-N-N-N ,N -TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE POLYMER BOUND O-BENZOTRIAZOLE-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM-HEXAFLUORO-PHOSPHATE O-BENZOTRIAZOLE-N,N,N',N'-TETRAMTHYL-URONIUM-HEXAFLUORO-PHOSPHATE N-[(1-H-BENZOTRIAZOL-1-YL)(DIMETHYLAMINO)METHYLENE]-N-METHYLMETHANAMINIUM HEXAFLUOROPHOSPHATE N-OXIDE O-(1H-benzotriazol-1-y1)-N,N,N'N'-tetramethyluronium Hexafluorophosphate(HBTU) O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM (HBTU ) HBTU (O-(BENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE) O-(Benzotriazole-N,N,N'',N''-tetramethyluronium hexafluorophosphate (HBTU) O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate [Coupling Reagent for Peptide] benzotriazolyl tetramethyluronium fluorophosphate HBTU, N,N,Nμ,Nμ-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (Benzotriazol-1-yloxy-dimethylaminomethylidene)-dimethylazanium hexafluorophosphate O-Benzotriazolyl-N,N,N',N'-tetramethyluronium hexafluorophosphate o-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate ,99% HBTU (o-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexaflu HBTU,2 bottles kit, 0.1M in HOBT/DMF (0.5M HOBT in DMF) HBTU,99% O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate≥ 99% (HPLC) O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE HBTU HBTU POLYMER BOUND HBTU-REAGENT HEXAFLUOROPHOSPHATE HBTU 2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONOIUM HEXAFLUORPHOSPHATE 1-[BIS(DIMETHYLAMINO)METHYLENE]-1H-BENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexaflorophosphate HBTU [O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM-HEXAFLUORO-PHOSPHATE] O-Benzotriazol-1-yl-tetramethyluronium 2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HBTU) HBTU, 3 bottles, 0.1M in HOBT/DMF (0.45M HOBT in DMF)1:1 1H-Benzotriazolium, 1-bis(dimethylamino)methylene-, hexafluorophosphate(1-), 3-oxide 2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUMHEXAFLUOROPHOSPHATE(HBTU) ORTHOBENZOTRIAZOLE1YLNNNNTETRAMETHYLURONIUMHEXAFLUOROPHOSPHATE HBTU [O-Benzotriazole-N N'-tetraMethyl-uroniuM-hexafluoro-phosphate] HBTU (o-(Benzotriazol-1-yl)-N,N,Nzzhlxy,Nzzhlxy-tetramethyluronium hexafluorophosphate) HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate,N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate, HBTU O-Benzotriazole-N,N HBTU N,N,N',N'-Tetramethyl-O-(benzotriazol-1-yl)uronium Hexafluorophosphate N,N,N',N'-TETRAMETHYL-O-(1H-BENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPHATE N,N,N',N'-TETRAMETHYL-O-(BENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPHATE O-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM HEXAFLUOROPHOSPHATE HBTU, [(1H-Benzotriazol-1-yl)oxy](dimethylamino)-N,N-dimethylmethaniminium hexafluorophosphate O-(1H-Benzotriazole-1-yl)-N,N,N,N-tetD23-RAMethyluroniuM Hexafluorophosphate HBTU >=98.0% (T) HBTU For Synthesis HBTU extrapure, 98% [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium 0-benzotriazol-1-yl-n,n, n',n'-tetramethyluronium 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide（HBTU） HBTU USP/EP/BP HBTU O-benzotriazol-l-yl-tetramethyluroniumhexafluorophosphate )-N,N,N',N'-tetramethyL