L-AP4
- CAS No.
- 23052-81-5
- Chemical Name:
- L-AP4
- Synonyms
- GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate
- CBNumber:
- CB1141944
- Molecular Formula:
- C4H10NO5P
- Molecular Weight:
- 183.1
- MDL Number:
- MFCD00083244
- MOL File:
- 23052-81-5.mol
- MSDS File:
- SDS
| Melting point | 207-215 °C |
|---|---|
| Boiling point | 491.7±55.0 °C(Predicted) |
| Density | 1.628±0.06 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | H2O : 50 mg/mL (273.07 mM; Need ultrasonic) |
| pka | 2.19±0.10(Predicted) |
| form | solid |
| color | White |
| Water Solubility | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 23052-81-5(CAS DataBase Reference) |
| FDA UNII | C8M58SS68H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ES7191700 | |||||||||
| NFPA 704 |
|
L-AP4 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7929 | L-(+)-2-Amino-4-phosphonobutyric acid optical purity optical purity: ≥95% (HPLC, Marfey′s reagent) | 23052-81-5 | 0.5mg | $103 | 2024-03-01 | Buy |
| Sigma-Aldrich | SRP4667 | GDF-5 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC) | 23052-81-5 | 50μG | $316 | 2022-05-15 | Buy |
| Sigma-Aldrich | 165300 | L-(+)-2-Amino-4-phosphonobutyric Acid | 23052-81-5 | 1mg | $88.3 | 2022-05-15 | Buy |
| Alfa Aesar | J64075 | (S)-(+)-2-Amino-4-phosphonobutyric acid, 99% | 23052-81-5 | 1mg | $93.65 | 2024-03-01 | Buy |
| Alfa Aesar | J64075 | (S)-(+)-2-Amino-4-phosphonobutyric acid, 99% | 23052-81-5 | 10mg | $216.65 | 2024-03-01 | Buy |
L-AP4 Chemical Properties,Uses,Production
Description
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-
Chemical Properties
white to off-white crystalline powder
Uses
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
Uses
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist.
Definition
ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids.
Biological Activity
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
storage
Room temperature
L-AP4 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11605 | 64 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
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