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ChemicalBook >> CAS DataBase List >>ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Structure
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE structure
CAS No.
161798-03-4
Chemical Name:
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Synonyms
2-(3-forMyl;Febuxostat-24;-4-isobutoxyphenyL;Febuxostat Impurity G;Febuxostat Impurity 2;Febuxostat Impurities2;Febuxostat Impurity Z18;Febuxostat Impurity Z2-2;Ethyl 2-(3-formyl-4-isobutoxyphenyl);Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz
CBNumber:
CB11474517
Molecular Formula:
C18H21NO4S
Molecular Weight:
347.43
MDL Number:
MFCD13194811
MOL File:
161798-03-4.mol
MSDS File:
SDS
Last updated:2023-10-30 17:09:20
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ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Properties

Melting point 158-160°C
Boiling point 495.9±55.0 °C(Predicted)
Density 1.183
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka 1.39±0.10(Predicted)
color Pale Yellow
CAS DataBase Reference 161798-03-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC E702955 Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 161798-03-4 2.5g $105 2021-12-16 Buy
TRC E702955 Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 161798-03-4 10g $340 2021-12-16 Buy
Ark Pharm P000219191 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98% 161798-03-4 10g $341 2021-12-16 Buy
Medical Isotopes, Inc. 35350 Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 95+% 161798-03-4 5G $600 2021-12-16 Buy
American Custom Chemicals Corporation CHM0068817 ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 95.00% 161798-03-4 5G $909.56 2021-12-16 Buy
Product number Packaging Price Buy
E702955 2.5g $105 Buy
E702955 10g $340 Buy
P000219191 10g $341 Buy
35350 5G $600 Buy
CHM0068817 5G $909.56 Buy

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production

Uses

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.

Synthesis

Preparation of Compound of formula III)[0094] A compound of formula II (10.0 gr, 34.33 mmol) was reacted with iso- butyl bromide (18.9 gr, 137.3 mmol) in the presence of potassium carbonate (19.0 gr, 137.3 mmol) and potassium iodide (2.3 gr, 13.7 mmol) in 60 ml dimethylformamide. The reaction was performed at about 70°C during 4 hours. The reaction mixture was extracted at 70°C using 300 ml ethyl acetate and 600 ml water. The separated aqueous phase was washed twice with 100 ml ethyl acetate. The combined organic phase was washed twice with 100 ml water and then concentrated to dryness. The resulting solid residue was re- crystallized from 70 ml ethyl acetate, filtered and dried under reduced pressure at about 40°C to provide a compound of formula III (8.9 gr, yield - 83percent). The Compound of formula III purity is 99.1percent (by HPLC).

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Suppliers

Global( 307)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Supplier Advantage
Henan Bao Enluo International TradeCo.，LTD 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58

View Lastest Price from ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE pictures 2024-04-24 ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
161798-03-4
 US $100.00-60.00 / kilograms 100kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carboxylate pictures 2024-03-28 Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carboxylate
161798-03-4
 US $0.00 / kg 25kg 98%-99% Inquiry PNP Biotech Co. Ltd
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE pictures 2024-01-02 ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
161798-03-4
 US $60.00-600.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

161798-03-4(ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE)Related Search:

Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 8
4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide 4-HYDROXYTHIOBENZAMIDE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 3-Cyano-4-isobutoxybenzoic acid
FeBuxostat Impurity 33 Febuxostat impurity 37 Febuxostat-d9

1of4

2-(3-forMyl 5-Thiazolecarboxylicacid, 2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylate Febuxostat Impurity 2 Febuxostat Impurity G 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-formyl-4-isobutoxyphenyl) ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 2-(3-Formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 5-carboxylato-1-ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-1H-1$l^{4},3-thiazol-1-yl 2-(3-forMyl-4-isobutoxyphenyI)-4-MethyIthiazole-5-carboxylic acid ethyl ester Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole- Ethyl-2-(3-Formyl-4-isobutoxy phenyl)-4-methyl-1,3-thiazole-5-carboxylate Febuxostat-24 Febuxostat Impurity Z18 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylicacid ethyl ester -4-isobutoxyphenyL Febuxostat intermediates，Ethyl 2-(3-Formyl-4-isobutoxyphenyl)- 4-Methylthiazole-5-Carboxylate Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2- Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carb... Febuxostat Impurities2 2 - (3-aldehyde-4-isobutyloxyphenyl) - 4-methylthiazole-5-carboxylic acid ethyl ester Ethyl 2-(3- aldehyde -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate 5-Thiazolecarboxylic acid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester (9CI, ACI) 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI) Febuxostat Impurity Z2-2 Febuxostat Impurity 2 ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate 161798-03-4 84006-10-6 1161798-03-4 Febuxostat intermediate 161798-03-4