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5-Benzyl L-glutamate N-carboxyanhydride

5-Benzyl L-glutamate N-carboxyanhydride structure

CAS No.: 3190-71-4

Chemical Name:: 5-Benzyl L-glutamate N-carboxyanhydride

Synonyms: L-Glu(OBzl)-NCA;5-Benzyl L-glutamate N-carboxyanhydride;Glu(Obzl)NCA;Glu(OBz)-NCA;H-GLU(OBZL)-NCA;L-Glu (OBn)-NCA;DL-Glu(Obzl)-NCA;Creatinine Impurity 5;Meloxicam Impurity 26;5-Benzyl-L-glutaMateNCA

CBNumber:: CB11479411

Molecular Formula:: C13H13NO5

Molecular Weight:: 263.25

MDL Number:: MFCD11046651

MOL File:: 3190-71-4.mol

Last updated:2024-04-09 13:47:46

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5-Benzyl L-glutamate N-carboxyanhydride Properties

Melting point	97-98℃
Density	1.293
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Acetonitrle (Slightly), Chloroform (Slightly), DMSO (Slightly), THF (Slightly)
pka	9.03±0.40(Predicted)
form	Solid
color	White to Off-White
Stability	Unstable in Solution
InChI	InChI=1S/C13H13NO5/c15-11(18-8-9-4-2-1-3-5-9)7-6-10-12(16)19-13(17)14-10/h1-5,10H,6-8H2,(H,14,17)/t10-/m0/s1
InChIKey	UGCBVSDSTGUPBC-JTQLQIEISA-N
SMILES	O1C(=O)[C@H](CCC(OCC2=CC=CC=C2)=O)NC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS05
Signal word	Danger
Hazard statements	H335-H318-H315
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310

5-Benzyl L-glutamate N-carboxyanhydride price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D486830	(4S)-2,5-Dioxo-4-oxazolidinepropanoicAcidPhenylmethylEster	3190-71-4	50g	$345	2021-12-16	Buy
TRC	D486830	(4S)-2,5-Dioxo-4-oxazolidinepropanoicAcidPhenylmethylEster	3190-71-4	100g	$595	2021-12-16	Buy
Medical Isotopes, Inc.	57575	(4S)-2,5-Dioxo-4-oxazolidinepropanoicAcidPhenylmethylEster	3190-71-4	10g	$1460	2021-12-16	Buy
Biosynth Carbosynth	FB63140	5-Benzyl L-glutamate N-carboxyanhydride	3190-71-4	25g	$200	2021-12-16	Buy
American Custom Chemicals Corporation	AAA0008857	5-BENZYL GLUTAMIC ACID ESTER NCA 95.00%	3190-71-4	5MG	$505.03	2021-12-16	Buy

Product number	Packaging	Price	Buy
D486830	50g	$345	Buy
D486830	100g	$595	Buy
57575	10g	$1460	Buy
FB63140	25g	$200	Buy
AAA0008857	5MG	$505.03	Buy

5-Benzyl L-glutamate N-carboxyanhydride Chemical Properties,Uses,Production

Description

5-Benzyl L-glutamate N-carboxyanhydride is a reactive derivative of L-glutamic acid, where the amino acid has been cyclised as an N-carboxyanhydride (NCA), a class of reagent known as Leuchs’ anhydrides. 5-Benzyl L-glutamate N-carboxyanhydride reacts with nucleophiles such as alcohols and amines to form esters and amides respectively. The opening of the N-carboxyanhydride to an ester or amide releases the amino acid amine which can also react as a nucleophile leading to polymerisation. These poly-amide polymers have been investigated as delivery platforms of Small Interfering RNA (si-RNA).

Uses

(4S)-2,5-Dioxo-4-oxazolidinepropanoic Acid Phenylmethyl Ester was used in the synthesis and physicochemical characterization of reduction-sensitive block copolymer for intracellular delivery of doxorubicin.

Uses

H-GLU(OBZL)-NCA was used in the synthesis and physicochemical characterization of reduction-sensitive block copolymer for intracellular delivery of doxoru bicin.

Synthesis

5-Benzyl L-glutamate N-carboxyanhydride (γ-benzyl-L-glutamate-N-carboxyanhydride)was synthesized by a reaction between γ-benzyl-L-glutamate (BLG) and triphosgene. Briefly, 14 g BLG was dissolved in 200 mL anhydrous THF in reaction vessel with condensing reflux unit at stirring state. Then the solution was heated to 50 °C, and 20 g triphosgene was added. The reaction continued until the solution turned from cloudy to clear. The reaction was cooled to room temperature, and N2 was concurrently inlet into the reaction system until the liquid volume did not decrease any more. The solution was precipitated by n-hexane. After being purified by EA/n-hexane and dried in a vacuum oven, 5-Benzyl L-glutamate N-carboxyanhydride was obtained and characterized by 1H nuclear magnetic resonance (1H NMR, Bruker, AV300) using CDCl3 as a solvent[1].

Synthesis

[1] Chen P, et al. Development of Light-Responsive Poly(γ-Benzyl-L-Glutamate) as Photo Switches by a One-Step NCA Method. Frontiers in Chemistry, 2020; 8.

5-Benzyl L-glutamate N-carboxyanhydride synthesis

Synthesis of 5-Benzyl L-glutamate N-carboxyanhydride from PHOSGENE and gamma-Benzyl L-glutamate

5-Benzyl L-glutamate N-carboxyanhydride Preparation Products And Raw materials

Raw materials

Preparation Products

5-Benzyl L-glutamate N-carboxyanhydride Suppliers

Global( 163)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7378	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Wuhan Boyuan Import & Export Co., LTD	+8615175982296	Mike@whby-chem.com	China	974	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	288	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Wuhan Boyuan Import & Export Co., LTD	58
Hebei Jimi Trading Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Sichuan Jiaying Lai Technology Co.,LTD	58

View Lastest Price from 5-Benzyl L-glutamate N-carboxyanhydride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	DL-Glu(Obzl)-NCA 3190-71-4	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-04-18	L-Glu(Obzl)-NCA 3190-71-4	US $0.00-0.00 / kg	1kg	98%, 99%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-04-09	5-Benzyl L-glutamate N-carboxyanhydride 3190-71-4	US $8.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

DL-Glu(Obzl)-NCA
3190-71-4
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

L-Glu(Obzl)-NCA
3190-71-4
US $0.00-0.00 / kg
98%, 99%
Sichuan HongRi Pharma-Tech Co.,Ltd

5-Benzyl L-glutamate N-carboxyanhydride
3190-71-4
US $8.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

3190-71-4(5-Benzyl L-glutamate N-carboxyanhydride)Related Search:

N-CARBAMYL-L-GLUTAMIC ACID N-Acetyl-L-glutamic acid 5-Benzyl L-glutamate N-carboxyanhydride gamma-Benzyl L-glutamate Boc-L-glutamic acid γ-benzyl ester N-carboxyanhydride

H-GLU(OBZL)-NCA Glutamic acid, 5-benzyl ester, NCA Glu(Obzl)NCA 5-Benzyl-L-glutaMateNCA L-5-Benzyl ester GlutaMic acid Anhydride NCA of benzyl protected L-glutaMic acid 4-Oxazolidinepropanoic acid, 2,5-dioxo-, phenylMethyl ester, (4S)- (S)-benzyl 3-(2,5-dioxooxazolidin-4-yl)propanoate (4S)-2,5-Dioxo-4-oxazolidinepropanoic Acid Phenylmethyl Ester L-GlutaMine O-Benzoyl N-carboxyanhydride -Benzyl 3-(2,5-dioxooxazolidin-4-yl) 5-benzyl L-Glutamate N-Carboxyanhydrie Benzyl (S)-2,5-Dioxooxazolidine-4-propanoate 5-Benzyl Glutamic Acid Ester Nca L-GLU(OBZL)-NCA(3190-71-4) benzyl 3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propanoate L-Glu (OBn)-NCA L-Glutamic acid γ-benzyl ester N-carboxyanhydride H-GLU(OBZL)-NCA USP/EP/BP 5-Benzyl L-glutamate N-carboxyanhydride L-Glu(OBzl)-NCA Glu(OBz)-NCA DL-Glu(Obzl)-NCA γ-Benzyl L-glutamate N-carboxyanhydride Creatinine Impurity 5 Meloxicam Impurity 26 L-glutamic acid, 5-benzyl ester, N-carboxylic intracyclic anhydride 3190-71-4 AMINOACIDS DERIVATIVES