3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- CAS No.
- 350997-39-6
- Chemical Name:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- Synonyms
- OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- CBNumber:
- CB11499417
- Molecular Formula:
- C9H6Cl2N2OS
- Molecular Weight:
- 261.13
- MDL Number:
- MFCD01993639
- MOL File:
- 350997-39-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1697 | OGG1 Inhibitor O8 ≥98% (HPLC) | 350997-39-6 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1697 | OGG1 Inhibitor O8 ≥98% (HPLC) | 350997-39-6 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 29769 | OGG1-IN-O8 | 350997-39-6 | 5mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 29769 | OGG1-IN-O8 | 350997-39-6 | 25mg | $330 | 2024-03-01 | Buy |
| Cayman Chemical | 29769 | OGG1-IN-O8 | 350997-39-6 | 1mg | $34 | 2024-03-01 | Buy |
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Chemical Properties,Uses,Production
Uses
O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
General Description
Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Biochem/physiol Actions
OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
storage
Store at +4°C
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2983 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 6870 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1831 | 55 |