(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- CAS No.
- 877397-65-4
- Chemical Name:
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Synonyms
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
- CBNumber:
- CB11503932
- Molecular Formula:
- C8H7Cl2FO
- Molecular Weight:
- 209.04
- MDL Number:
- MFCD09863793
- MOL File:
- 877397-65-4.mol
| Boiling point | 261.3±35.0 °C(Predicted) |
|---|---|
| Density | 1.406±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 13.30±0.20(Predicted) |
| form | Solid |
| color | White |
| InChI | InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3 |
| InChIKey | JAOYKRSASYNDGH-UFLUHPNLNA-N |
| SMILES | [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r| |
| CAS DataBase Reference | 877397-65-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2906290090 | |||||||||
| NFPA 704 |
|
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H65374 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95% | 877397-65-4 | 1g | $61.2 | 2023-06-20 | Buy |
| Alfa Aesar | H65374 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95% | 877397-65-4 | 5g | $273 | 2023-06-20 | Buy |
| Alfa Aesar | H65374 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95% | 877397-65-4 | 250mg | $17.4 | 2021-12-16 | Buy |
| TRC | D434235 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol | 877397-65-4 | 50g | $1075 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD33749 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol | 877397-65-4 | 10g | $200 | 2021-12-16 | Buy |
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Uses,Production
Uses
(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).
Uses
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Uses
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor ( c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Synthesis
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7377 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
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- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol: properties, synthesis and safety
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View Lastest Price from (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-12-29 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-12-01 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
|
US $0.00-0.00 / kg | 1kg | ＞98% by HPLC | 10kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. |
-
- (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
- US $0.00-0.00 / kg
- ＞98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
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