L-BUTHIONINE-(S,R)-SULFOXIMINE
- CAS No.
- 83730-53-4
- Chemical Name:
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- Synonyms
- L-BSO;nsc326231;L-Butionine sulfoximine;L-BUTHIONINESULPHOXIMINE;L-BUTHIONINE-SULFOXIMINE;D-Buthionine Sulfoximine;L-BUTHIONINE-[S,R]-SULFOXIME;Buthionine - sulfoxide iMine;L-BUTHIONINE-S,R-SULPHOXIMINE;L-BUTHIONINE-(S,R)-SULFOXIMINE
- CBNumber:
- CB1150667
- Molecular Formula:
- C8H18N2O3S
- Molecular Weight:
- 222.31
- MDL Number:
- MFCD00067000
- MOL File:
- 83730-53-4.mol
- MSDS File:
- SDS
| Melting point | 224-228 °C (dec.) |
|---|---|
| Boiling point | 382.3±52.0 °C(Predicted) |
| Density | 1.29 |
| refractive index | 1.6300 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL, clear, colorless to faintly yellow |
| form | Fine Powder |
| color | White |
| BRN | 2367136 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily. |
| CAS DataBase Reference | 83730-53-4 |
| FDA UNII | EEY8DZS103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EK7713440 | |||||||||
| F | 10 | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
L-BUTHIONINE-(S,R)-SULFOXIMINE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B2515 | L-Buthionine-sulfoximine ≥97% (TLC) | 83730-53-4 | 1g | $444 | 2024-03-01 | Buy |
| Sigma-Aldrich | B2515 | L-Buthionine-sulfoximine ≥97% (TLC) | 83730-53-4 | 5g | $1560 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.08228 | L-ButhionineSulfoximine-CAS83730-53-4-Calbiochem | 83730-53-4 | 100mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 14484 | Buthionine Sulfoximine ≥98% | 83730-53-4 | 250mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 14484 | Buthionine Sulfoximine ≥98% | 83730-53-4 | 1g | $286 | 2024-03-01 | Buy |
L-BUTHIONINE-(S,R)-SULFOXIMINE Chemical Properties,Uses,Production
Description
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
Chemical Properties
White Crystalline Solid
Uses
L-Buthionine-(S,R)-sulfoximine is a potent and specific inhibitor of alpha-glutamylcysteine synthetase.
Uses
Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
Uses
inhibitor of gamma-glutamylcysteine synthetase
Definition
ChEBI: L-buthionine-(S,R)-sulfoximine is a 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents. It has a role as a ferroptosis inducer and an EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor.
Hazard
A reproductive hazard.
Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
storage
Store at -20°C
References
1) Lu?et al.?(2009),?Regulation of glutathione synthesis; Mol. Aspects Med.?30?42 2) Lee?et al.?(2008),?Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem.?12?174 3) Qiwei et al. (2016),?The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett.?11?474 4) Glasuer and Chandel (2014),?Targeting antioxidants for cancer therapy; Biochem. Pharmacol.?92?90
L-BUTHIONINE-(S,R)-SULFOXIMINE Preparation Products And Raw materials
Raw materials
Preparation Products
L-BUTHIONINE-(S,R)-SULFOXIMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18457 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
View Lastest Price from L-BUTHIONINE-(S,R)-SULFOXIMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | L-BUTHIONINE-(S,R)-SULFOXIMINE
83730-53-4
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
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- L-BUTHIONINE-(S,R)-SULFOXIMINE
83730-53-4
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co