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L-BUTHIONINE-(S,R)-SULFOXIMINE

L-BUTHIONINE-(S,R)-SULFOXIMINE
L-BUTHIONINE-(S,R)-SULFOXIMINE structure
CAS No.
83730-53-4
Chemical Name:
L-BUTHIONINE-(S,R)-SULFOXIMINE
Synonyms
L-BSO;nsc326231;L-BUTHIONINE-SULFOXIMINE;L-BUTHIONINESULPHOXIMINE;D-Buthionine Sulfoximine;Buthionine - sulfoxide iMine;L-BUTHIONINE-[S,R]-SULFOXIME;L-BUTHIONINE-S,R-SULPHOXIMINE;L-BUTHIONINE-(S,R)-SULFOXIMINE;L-BUTHIONINE (R,S)-SULFOXIMINE
CBNumber:
CB1150667
Molecular Formula:
C8H18N2O3S
Formula Weight:
222.31
MOL File:
83730-53-4.mol

L-BUTHIONINE-(S,R)-SULFOXIMINE Properties

Melting point:
224-228 °C (dec.)
Density 
1.29
refractive index 
1.6300 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless to faintly yellow
form 
Fine Powder
color 
White
BRN 
2367136
CAS DataBase Reference
83730-53-4

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
RTECS  EK7713440
10
HS Code  29309090

L-BUTHIONINE-(S,R)-SULFOXIMINE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B2515 L-Buthionine-sulfoximine ≥97% (TLC) 83730-53-4 1g $314 2018-11-13 Buy
Sigma-Aldrich B2515 L-Buthionine-sulfoximine ≥97% (TLC) 83730-53-4 5g $1090 2018-11-13 Buy
Cayman Chemical 14484 Buthionine Sulfoximine ≥98% 83730-53-4 250mg $65 2018-11-13 Buy
Cayman Chemical 14484 Buthionine Sulfoximine ≥98% 83730-53-4 1g $234 2018-11-13 Buy
Sigma-Aldrich B2515 L-Buthionine-sulfoximine ≥97% (TLC) 83730-53-4 500mg $200 2018-11-13 Buy

L-BUTHIONINE-(S,R)-SULFOXIMINE Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

A potent and specific inhibitor of alpha-glutamylcysteine synthetase

Uses

inhibitor of gamma-glutamylcysteine synthetase

Uses

Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.

Hazard

A reproductive hazard.

L-BUTHIONINE-(S,R)-SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products


L-BUTHIONINE-(S,R)-SULFOXIMINE Suppliers

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83730-53-4(L-BUTHIONINE-(S,R)-SULFOXIMINE)Related Search:


  • L-BUTHIONINE-SULFOXIMINE
  • L-BUTHIONINE (R,S)-SULFOXIMINE
  • L-BUTHIONINE-[S,R]-SULFOXIME
  • L-BUTHIONINE-(S,R)-SULFOXIMINE
  • L-BSO
  • nsc326231
  • L-BUTHIONINESULPHOXIMINE
  • (S)-2-Amino-4-(S-butylsulfonimidoyl)butyric acid
  • L-Buthionine-(S,R)-sulfoximine,99%
  • L-Buthionine-(S,R)-sulfoxiMine, 99% 1GR
  • Buthionine - sulfoxide iMine
  • -2-Amino-4-(butylsulfonimidoyl)
  • 83730-53-4
  • Biochemicals and Reagents
  • BioChemical
  • Glutathione biosynthesis and Glu-Cys Ligase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • L-BUTHIONINE-S,R-SULPHOXIMINE
  • (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic Acid
  • D-Buthionine Sulfoximine
  • Core Bioreagents
  • D to
  • Enzyme InhibitorsEnzyme Inhibitors by Enzyme
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • D to K
  • Organic Covalent Modifiers
  • Glutathione S-Transferase Agents
  • Sulfur & Selenium Compounds
  • Enzyme InhibitorsResearch Essentials
  • Glutathione biosynthesis and Glu-Cys Ligase
  • Cancer Research
  • Chemopreventive Agents
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