Mozavaptan Hydrochloride
- CAS No.
- 138470-70-9
- Chemical Name:
- Mozavaptan Hydrochloride
- Synonyms
- Mozavaptan HCl;OPC 31260 hydrochloride;Mozavaptan Hydrochloride;MOROBKPIULFQDC-UHFFFAOYSA-N;OPC 31260 hydrochloride >=98% (HPLC);5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride;N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride;N-[4-[[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methylbenzamide hydrochloride;Benzamide,N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-,hydrochloride (1:1)
- CBNumber:
- CB11508553
- Molecular Formula:
- C27H29N3O2.ClH
- Molecular Weight:
- 464.006
- MDL Number:
- MFCD11111965
- MOL File:
- 138470-70-9.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ≥15mg/mL |
| form | powder |
| color | white to tan |
| FDA UNII | F39AR1YW1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Mozavaptan Hydrochloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O1266 | OPC 31260 hydrochloride ≥98% (HPLC) | 138470-70-9 | 10mg | $95.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | O1266 | OPC 31260 hydrochloride ≥98% (HPLC) | 138470-70-9 | 50mg | $388 | 2024-03-01 | Buy |
| Cayman Chemical | 16664 | Mozavaptan (hydrochloride) ≥98% | 138470-70-9 | 5mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16664 | Mozavaptan (hydrochloride) ≥98% | 138470-70-9 | 10mg | $58 | 2024-03-01 | Buy |
| Cayman Chemical | 16664 | Mozavaptan (hydrochloride) ≥98% | 138470-70-9 | 50mg | $126 | 2024-03-01 | Buy |
Mozavaptan Hydrochloride Chemical Properties,Uses,Production
Uses
Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 μM) and kidney (V2; IC50 = 14 nM). At 10-100 μg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats. The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied.
Definition
ChEBI: Mozavaptane hydrochloride is a member of benzamides.
Biochem/physiol Actions
OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.
Mozavaptan Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Mozavaptan Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3420 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9664 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |