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GROWTH HORMONE, HUMAN

GROWTH HORMONE, HUMAN
GROWTH HORMONE, HUMAN structure
CAS No.
12629-01-5
Chemical Name:
GROWTH HORMONE, HUMAN
Synonyms
GH;STH;HGH;cb311;D02691;sj0011;Nutropin;ly137998;crecormon;LY-137988
CBNumber:
CB1151396
Molecular Formula:
C990H1529N263O299S7
Formula Weight:
22124.12
MOL File:
Mol file

GROWTH HORMONE, HUMAN Properties

alpha 
25 -38.7° (0.1M acetic acid)
storage temp. 
2-8°C
form 
lyophilized powder

SAFETY

Hazard Codes  B
WGK Germany  3
RTECS  TO7385000

GROWTH HORMONE, HUMAN price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 869008-M Somatropin 12629-01-5 50ug-m $199 2018-11-20 Buy
Sigma-Aldrich 869008-M Somatropin 12629-01-5 100ug-m $379 2018-11-20 Buy
Sigma-Aldrich 1615708 Somatropin United States Pharmacopeia (USP) Reference Standard 12629-01-5 3.86mg $450.8 2018-11-23 Buy
Sigma-Aldrich S0947000 Somatropin European Pharmacopoeia (EP) Reference Standard 12629-01-5 s0947000 $336 2018-11-23 Buy

GROWTH HORMONE, HUMAN Chemical Properties,Uses,Production

Description

Somatotropin, a second-generation (methionine-free) human growth hormone produced by recombinant technology, was launched in the U.S.A. for the treatment of growth failure in children due to chronic renal insufficiency before transplantation and for the long term treatment of short stature in children with growth failure due to a lack of endogenous growth hormone secretion. The efficacy of somatotropin is reportedly comparable to the first biosynthetic growth hormone somatrem, which contains a methionyl residue, but with less frequent antibody formation and rarely causes allergic effects or impairs growth response. Somatotropin is also in clinical trials for the treatment of growth hormone deficiency in adults and is currently under approval review for Turner's syndrome.

Description

Somatropin is a growth hormone useful in the treatment of hypopituitaxy dwarfism and other disorders resulting from growth hormone deficiencies. Lilly has used recombinant technology to produce human somatropin identical to the natural hormone. Somamm, the N-methionyl derivative of somatropin, was launched in 1985 by Genentech for the same indications.

Chemical Properties

White or almost white powder.

Originator

Genentech (U.S.A.)

Originator

Lilly (USA)

Uses

Human Growth Hormone is a hormone (growth).

brand name

(Genentech); Genotropin (Pharmacia); Humatrope (Lilly);Nutropin (Genentech); Saizen (Serono); Serostim (Serono);22krl;Antuitrin growth;Antuitrin-t;Asellacrin;Cb 311;Corpormon;Crescormon;Grorm;Human groth hormone;Human growth hormon;Leutrophin;Nanormin;Nanormon;Phynatol;Phyol;Phyoneon;Protopin;Protropin;Rx 099916;Somacton;Somatonorm;Somatormone;Somatotrope choay;Somatrofin;Somatropin;Nutropln.

World Health Organization (WHO)

Somatropin, a pituitary-derived human growth hormone, has been used in the treatment of hypopituitary dwarfism for over twenty years. In 1985 it became known that Creutzfeldt-Jakob disease, a potentially fatal form of brain degeneration resulting from a slow neurotropic viral infection, had developed in several patients who had received preparations of somatropin in the late 1960s/early 1970s. This led to the withdrawal of these preparations in many countries. An international collaborative effort was maintained to identify newlydiagnosed cases. By 1990 a total of 30 such cases had been notified. More efficient purification procedures introduced during the 1970s greatly reduced the risk of viral contamination, but products containing pituitary-derived somatropin have been superseded by biosynthetically-manufactured preparations produced using recombinant techniques.

General Description

Somatropin for injection(Humatrope) is a natural-sequence human GH of rDNAorigin. Its composition and sequence of amino acids areidentical with those of human GH of pituitary origin. It isadministered intramuscularly or subcutaneously. Thedosage range is 0.05 to 0.1 IU.

Clinical Use

Human Growth Hormone(hGH) is a protein that is essential for normal growth and developmentin humans. Human Growth Hormone(hGH) affects many aspects of humandevelopment and metabolism including longitudinalgrowth, regulation (increase) of protein synthesis and lipolysis,and regulation (decrease) of glucose metabolism. Human Growth Hormone(hGH)has been used as a drug since the 1950s, and it has been extremelysuccessful in the treatment of classic growth hormonedeficiency, chronic renal insufficiency, Turner syndrome,failure to lactate in women, and Prader-Willisyndrome. In its long history, the hormone has been remarkablysuccessful and free of side effects.

GROWTH HORMONE, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products


GROWTH HORMONE, HUMAN Suppliers

Global( 74)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Hebei Minshang Biotechnology Co., Ltd
+86-13230167943
cathy@hbminshang.com CHINA 279 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 701 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 928 58
Hebei Chisure Biotechnology Co., Ltd.
+8613091036086; +8613292890173
+8613292893290 sandy@speedgainpharma.com; luna@speedgainpharma.com CHINA 1019 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 684 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Hebei Aicrowe Biotech Co., Ltd
0311-66855331
aicrowe@kf-chem.com CHINA 308 58

View Lastest Price from GROWTH HORMONE, HUMAN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-05-15 GROWTH HORMONE, HUMAN CAS 12629-01-5 HGH kf-wang(at)kf-chem.com
12629-01-5
US $50.00 / Kg/Drum 10g 99.6% 5000 Hebei Aicrowe Biotech Co., Ltd
2018-12-19 GROWTH HORMONE, HUMAN
12629-01-5
US $8.00 / kg 1kg 99% 10MT career henan chemical co
2018-12-26 HGH somatropin CAS12629-01-5 Human Growth Hormone
12629-01-5
US $10.00 / kg 1kg 99% 5000kg Hebei Chisure Biotechnology Co., Ltd.

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