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6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile

6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile structure
CAS No.
252917-06-9
Chemical Name:
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile
Synonyms
CT99021;CHIR-99021;CHIR-99012;CHIR-99021, >=98%;GSK-3 Inhibitor XVI;CHIR 99021(CT 99021);CT 99021(CHIR 99021);CHIR-99021 (CT99021) HCl;CHIR 911, GSK-3 Inhibitor XVI;CHIR-99021 GSK-3 Inhibitor XVI
CBNumber:
CB11516097
Molecular Formula:
C22H18Cl2N8
Formula Weight:
465.35
MOL File:
252917-06-9.mol

6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile Properties

Density 
1.48
storage temp. 
?20°C
solubility 
DMSO: soluble2mg/mL, clear (warmed)
form 
powder
color 
white to light brown
InChIKey
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS DataBase Reference
252917-06-9
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H315-H319-H335
Precautionary statements  P261-P264-P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  29335990

6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 361559 GSK-3 Inhibitor XVI 252917-06-9 5mg $239 2018-11-20 Buy
Sigma-Aldrich 361571 InSolution? GSK-3 Inhibitor XVI, CHIR99021 252917-06-9 5mg $239 2018-11-22 Buy
Cayman Chemical 13122 CHIR99021 ≥95% 252917-06-9 1mg $25 2018-11-13 Buy
Cayman Chemical 13122 CHIR99021 ≥95% 252917-06-9 5mg $69 2018-11-13 Buy
Sigma-Aldrich SML1046 CHIR99021 ≥98% (HPLC) 252917-06-9 5mg $91.6 2018-11-13 Buy

6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile Chemical Properties,Uses,Production

Uses

A specific GSK-3 inhibitor of GSK-3β and GSK-3α with IC50s of 5 nM and 10 nM, respectively.

Uses

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.

Definition

ChEBI: A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.

6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products


6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile Suppliers

Global( 127)Suppliers
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Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
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sales@coreychem.com CHINA 30002 58
Biochempartner
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
BOC Sciences
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1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
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ChemCell Biomedicine Co.,Ltd. 13556033878 QQ:2965585218
0086-0757-85406358 chemcell@hotmail.com China 156 52
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4030 58
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
021-33632979 zijuecai@targetmol.com China 2994 58

View Lastest Price from 6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile
252917-06-9
US $2.00 / kg 1kg 99% 100kg career henan chemical co

252917-06-9(6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile)Related Search:


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