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Fursultiamine

CAS No.
804-30-8
Chemical Name:
Fursultiamine
Synonyms
ttfd;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin;alinaminf;Aliaron F;fursultiamin
CBNumber:
CB1161096
Molecular Formula:
C17H26N4O3S2
Molecular Weight:
398.54
MDL Number:
MFCD00867383
MOL File:
804-30-8.mol
MSDS File:
SDS
Last updated:2024-03-26 14:13:49

Fursultiamine Properties

Melting point 130-136°C (decompos.)
Boiling point 652.3±55.0 °C(Predicted)
Density 1.29
refractive index 1.6270 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form Solid
pka 14.42±0.10(Predicted)
color White to Off-White
CAS DataBase Reference 804-30-8(CAS DataBase Reference)
FDA UNII 05J61265PX
NCI Drug Dictionary fursultiamine

SAFETY

Risk and Safety Statements

Toxicity LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC F865235 Fursultiamine 804-30-8 25mg $145 2021-12-16 Buy
AK Scientific M514 Fursultiamine 804-30-8 25mg $98 2021-12-16 Buy
American Custom Chemicals Corporation API0002785 FURSULTIAMINE 95.00% 804-30-8 1G $682.5 2021-12-16 Buy
American Custom Chemicals Corporation API0002785 FURSULTIAMINE 95.00% 804-30-8 5G $1297.64 2021-12-16 Buy
AHH API-1717 Fursultiamine 98% 804-30-8 5g $800 2021-12-16 Buy
Product number Packaging Price Buy
F865235 25mg $145 Buy
M514 25mg $98 Buy
API0002785 1G $682.5 Buy
API0002785 5G $1297.64 Buy
API-1717 5g $800 Buy

Fursultiamine Chemical Properties,Uses,Production

Description

Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.

Chemical Properties

white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.

Originator

Alinamin F,Takeda,Japan,1961

Uses

Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.

Application

Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.

Preparation

Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.

Definition

ChEBI: Fursultiamine is a member of pyrimidines.

Manufacturing Process

To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).

Therapeutic Function

Enzyme cofactor vitamin

Fursultiamine Preparation Products And Raw materials

Global( 158)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Natural Micron Pharm Tech Co.,LTD
+86-18653895227 info@nmpharmtech.com China 94 58
Wuhan Qiami Technology Co., Ltd
+8618062705058 qiamichem@163.com China 148 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 415 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460 faith@widelychemical.com CHINA 742 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

View Lastest Price from Fursultiamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fursultiamine pictures 2024-03-26 Fursultiamine
804-30-8
US $110.00-90.00 / kilogram 1kilogram 99% 10 tons/per week Henan Tengmao Chemical Technology Co. LTD
Fursultiamine pictures 2023-10-09 Fursultiamine
804-30-8
US $20.00-5.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
Fursultiamine pictures 2023-09-06 Fursultiamine
804-30-8
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • Fursultiamine pictures
  • Fursultiamine
    804-30-8
  • US $110.00-90.00 / kilogram
  • 99%
  • Henan Tengmao Chemical Technology Co. LTD
  • Fursultiamine pictures
  • Fursultiamine
    804-30-8
  • US $20.00-5.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • Fursultiamine pictures
  • Fursultiamine
    804-30-8
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
((tetrahydrofurfuryl)dithio)-1-butenyl)- adventan alinaminf diteftin fursultiamin n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide Fursutiamine Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI) Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]- N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide Retar B1 Tetrahydrofurfuryl thiamine disulfide Thiamin tetrahydrofurfuryl disulfide N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide Fursultiamine (base and/or unspecified salts) N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahyclrofurfury(dithio-1-bute Fursultiamine###Fursultiamine Hcl FURSULTIAMINE Fursultiamine Base Fursultiaminlim N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma FURSULTIAMINE HYDROCHLORIDE Aliaron F Alinaxin N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide judolor linamin retar-b(sub1) thiaminetetrahydrofurfuryldisulfide ttfd Fursultiamine Hydrochloride RS Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]- THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD) Fursultiamine USP/EP/BP Fursultiamine HCL JP USP/EP/BP Derivative Fursultiamine N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide Furan thiamine 804-30-8 C17H26N4O3S2 Vitamins and derivatives