3-HYDROXY-P-BUTYROPHENETIDINE
- CAS No.
- 1083-57-4
- Chemical Name:
- 3-HYDROXY-P-BUTYROPHENETIDINE
- Synonyms
- BUCETIN;betadid;BUCETINE;LABOTEST-BB LT00771786;Inhibitor,Bucetin,inhibit;3-hydroxy-p-butyrophenetidid;3-hydroxybutyr-4-phenetidide;3-HYDROXY-P-BUTYROPHENETIDIDE;3-HYDROXY-P-BUTYROPHENETIDINE;4’-ethoxy-3-hydroxy-butyranilid
- CBNumber:
- CB1168297
- Molecular Formula:
- C12H17NO3
- Molecular Weight:
- 223.27
- MDL Number:
- MFCD00021906
- MOL File:
- 1083-57-4.mol
| Melting point | 160 °C |
|---|---|
| Boiling point | 364.56°C (rough estimate) |
| Density | 1.1223 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | 14.07±0.70(Predicted) |
| color | White to Off-White |
| Merck | 14,1458 |
| CAS DataBase Reference | 1083-57-4 |
| FDA UNII | 6M7CVQ8PF8 |
| ATC code | N02BE04 |
| EPA Substance Registry System | Butanamide, N-(4-ethoxyphenyl)-3-hydroxy- (1083-57-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H312+H332-H350 | |||||||||
| Precautionary statements | P201-P202-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-46-20/21/22 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EU0900000 | |||||||||
| HS Code | 2924.29.7790 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 790 i.p., 2800 orally (Fujimura) | |||||||||
| NFPA 704 |
|
3-HYDROXY-P-BUTYROPHENETIDINE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4027 | Bucetin analytical standard | 1083-57-4 | 10g | $26.7 | 2022-05-15 | Buy |
| TCI Chemical | H0371 | 3-Hydroxy-p-butyrophenetidine >98.0%(GC) | 1083-57-4 | 25g | $40 | 2024-03-01 | Buy |
| TRC | B689420 | Bucetin | 1083-57-4 | 1g | $135 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0010550 | 3-HYDROXY-P-BUTYROPHENETIDINE 95.00% | 1083-57-4 | 1G | $626.08 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 44114 | Bucetin | 1083-57-4 | 10g | $650 | 2021-12-16 | Buy |
3-HYDROXY-P-BUTYROPHENETIDINE Chemical Properties,Uses,Production
Originator
Bucetin,ZYF Pharm Chemical
Uses
Bucetin is an antipyretic and analgesic drug that is chemically similar to phenacetin. The use of Bucetin has been withdrawn due to renal toxicity.
Uses
3-Hydroxy-p-butyrophenetidine is an antipyretic and analgesic drug that is chemically similar to phenacetin (P294580). The use of 3-Hydroxy-p-butyrophenetidine has been withdrawn due to renal toxicity.
Definition
ChEBI: Bucetin is an organic molecular entity.
Manufacturing Process
Bucetin may be prepared from acetoacetic acid p-phenetidide as follows:
5.5 parts of acetoacetic acid p-phenetidide, suspended in 600 parts by volume
of methanol, are hydrogenated at 80°-85°C with a nickel catalyst supported
on kiesel-guhr. When the theoretical quantity of hydrogen has been absorbed,
the solution is cooled, then filtered, and the filtrate is concentrated. The solid
residue is recrystallized from six times its weight of isopropanol. β-
Hydroxybutyric acid p-phenetidide is obtained in an almost quantitative yield
in the form of white crystals which melt at 160°C.
55 parts of acetoacetic acid p-phenetidide, suspended in 500 parts by volume
of methanol, are hydrogenated with Raney nickel at 70°C. When the
theoretical quantity of hydrogen has been absorbed, the solution is cooled,
then filtered, and the filtrate is concentrated. The solid residue is recrystallized
from six times its weight of isopropanol. 51 parts (93 % of the theoretical
yield) of β-hydroxybutyric acid p-phenetidide are obtained in the form of white
crystals, which are sparingly soluble in water and melt at 160°C.
A mixture of 5 g of aluminum amalgam, 5 g of acetoacetic acid p-phenetidide
and 50 ml of ethanol are gently heated for 30 minutes. After filtering off the
reducing agent with suction, water is added to the filtrate, and the latter is
then acidified with 2 N hydrochloric acid. β-Hydroxybutyric acid p-phenetidide
melting at 160°C crystallizes in almost quantitative yield in the form of white
crystals.
brand name
Beelin;Bonanza;Haitmin;Hoe 15239;New isomidon;Ringl-s.
Therapeutic Function
Analgesic
World Health Organization (WHO)
Bucetin is an analogue of phenacetin. See WHO comment for phenacetin.
3-HYDROXY-P-BUTYROPHENETIDINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1009 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9821 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from 3-HYDROXY-P-BUTYROPHENETIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-18 | 3-HYDROXY-P-BUTYROPHENETIDINE
1083-57-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-08-30 | 3-HYDROXY-P-BUTYROPHENETIDINE
1083-57-4
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- 3-HYDROXY-P-BUTYROPHENETIDINE
1083-57-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-HYDROXY-P-BUTYROPHENETIDINE
1083-57-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co