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N-Methyl-L-proline

N-Methyl-L-proline structure

CAS No.: 475-11-6

Chemical Name:: N-Methyl-L-proline

Synonyms: N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O

CBNumber:: CB1179181

Molecular Formula:: C6H11NO2

Molecular Weight:: 129.16

MDL Number:: MFCD00011565

MOL File:: 475-11-6.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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N-Methyl-L-proline Properties

Melting point	114-116 °C(lit.)
Boiling point	227℃
Density	1.153
Flash point	91.1℃
refractive index	1.5000
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	2.37±0.20(Predicted)
form	Powder
color	White to off-white
Water Solubility	Soluble in water and methanol(both 50 mg/ml-clear-colorless solution)
InChI	InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey	CWLQUGTUXBXTLF-YFKPBYRVSA-N
SMILES	C(O)(=O)[C@@H]1CCCN1C
CAS DataBase Reference	475-11-6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

WGK Germany

HazardClass

IRRITANT

NFPA 704

	0
0		0

N-Methyl-L-proline price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M8021	N-Methyl-L-proline	475-11-6	500mg	$489	2023-06-20	Buy
Sigma-Aldrich	M8021	N-Methyl-L-proline	475-11-6	1g	$844	2023-06-20	Buy
Alfa Aesar	H63241	N-Methyl-L-proline, 98%	475-11-6	1g	$347	2021-12-16	Buy
Alfa Aesar	H63241	N-Methyl-L-proline, 98%	475-11-6	250mg	$117	2021-12-16	Buy
Usbiological	240080	N-Methyl-L-proline, 98%	475-11-6	250mg	$206	2021-12-16	Buy

Product number	Packaging	Price	Buy
M8021	500mg	$489	Buy
M8021	1g	$844	Buy
H63241	1g	$347	Buy
H63241	250mg	$117	Buy
240080	250mg	$206	Buy

N-Methyl-L-proline Chemical Properties,Uses,Production

Uses

N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.

Definition

ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.

Synthesis

L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.
N-Methyl-L-proline synthesis

N-Methyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-L-proline Suppliers

Global( 144)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
GenicBio Limited	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from N-Methyl-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-01-31	N-METHYL-L-PROLINE MONOHYDRATE 475-11-6	US $100.00 / KG	1KG	99%	5000kg/week	Hebei Mojin Biotechnology Co., Ltd
2022-02-19	N-Methyl-l-proline 475-11-6	US $0.00 / KG	1KG	97.8%	100 tons	Honest Joy Holdings Limited
2019-12-20	N-METHYL-L-PROLINE MONOHYDRATE 475-11-6	US $1.00 / g	1g	99%	KG/T	Career Henan Chemical Co

N-METHYL-L-PROLINE MONOHYDRATE
475-11-6
US $100.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

N-Methyl-l-proline
475-11-6
US $0.00 / KG
97.8%
Honest Joy Holdings Limited

N-METHYL-L-PROLINE MONOHYDRATE
475-11-6
US $1.00 / g
99%
Career Henan Chemical Co

N-Methyl-L-proline Spectrum

N-Methyl-L-proline(475-11-6)MS N-Methyl-L-proline(475-11-6)¹HNMR

475-11-6( N-Methyl-L-proline)Related Search:

N-METHYL-L-PROLINE MONOHYDRATE 98 N-Methyl-L-proline N-Cbz-Hydroxy-L-proline L-Alanyl-L-proline BOC-HYP(BZL)-OH

BOC-L-Proline N-(2,4-DINITROPHENYL)-L-PROLINE Fmoc-Pro-OH GLYCYL-L-PROLINE 4-METHOXY-2-METHYLBENZOIC ACID

(S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER L-Proline H-ALA-PRO-OME HCL Z-ALA-PRO-OH PHE-PRO

H-PRO-PRO-OH HCL H-MET-PRO-OH H-VAL-PRO-OTBU HCL

1of4

N-ME-L-PROLINE HYDROCHLORIDE N-ME-PROLINE N-ME-PRO-OH HCL N-METHYL-L-PROLINE MONOHYDRATE PYRD(2)-OH H2O N-ALPHA-METHYL-L-PROLINE N-ALPHA-METHYL-L-PROLINE HYDRATE N-ALPHA-METHYL-L-PYRROLIDINE-2-CARBOXYLIC ACID HYDRATE MEPYRD(2)-OH H2O H-MEPRO-OH H2O 1-Methylproline Hygric acid (2S)-1-Methylpyrrolidine-2-carboxylic acid (-)-Hygrinic acid (2S)-1-Methyl-2-pyrrolidinecarboxylic acid Hygrinic acid tert-butyl N-[4-(aminomethyl)cyclohexyl]carbamate,hydrochloride N-Me-L-Pro-OH N-Methyl-L-proline98+% N-METHYL-L-PROLINE MONOHYDRATE HCL L-Proline, 1-methyl- N-METHYL-L-PROLINE MONOHYDRATE USP/EP/BP N-Methylproline 1-Methyl-L-proline N-METHYL-L-PROLINE N-ME-PRO-OH 475-11-6 I - Z Modified Amino Acids Biochemicals and Reagents BioChemical Amino Acids and Peptides amino acids Amino Acids I - Z Modified Amino Acids